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View Structure Prediction Details

Protein: SPBC839.16
Organism: Schizosaccharomyces pombe
Length: 937 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPBC839.16.

Description E-value Query
Range
Subject
Range
C1TC_RAT - C-1-tetrahydrofolate synthase, cytoplasmic OS=Rattus norvegicus GN=Mthfd1 PE=1 SV=3
1384.0 [0..2] [936..4]
gi|89272471 - gi|89272471|emb|CAJ82471.1| methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltet...
1380.0 [0..2] [936..3]
MTHFD1 - methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase...
1376.0 [0..2] [936..4]
gi|148233902, gi... - gi|27924215|gb|AAH45019.1| Mthfd1-prov protein [Xenopus laevis], gi|148233902|ref|NP_001080574.1| C1...
1372.0 [0..2] [936..3]
gi|39973679, gi|... - gi|39973679|ref|XP_368230.1| hypothetical protein MG01014.4 [Magnaporthe grisea 70-15], gb|EAA49356....
1371.0 [0..2] [936..125]

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Predicted Domain #1
Region A:
Residues: [1-297]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLLEGTSL ARKVREELRE QISSIKSVDP YFNVSLKIIQ VGGREDSNVY VRMKTRAANE  60
   61 AGISCEHVNF PEDITEYDLL LAIKGFNEDP TVHGIIVQLP LPAHINEQII TEAVAPEKDV 120
  121 DGFCETNLGK LTKREGQPLF TACTPKGIMC ILKHYGINVQ GKHAVVIGRS NIVGRPMSIL 180
  181 LEKANATVTL CHSKTESIAD IVRTADIVVA AIGIPHFVKA DWLKKGVVAI DVGINSIPDA 240
  241 TKKSGYRLTG DIDFENAKEV ASAITPVPGS VGPMTVAMLL QNVVESAVRF RKMSRKR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 110.0
Match: 1diaA
Description: Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [298-937]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPTLLPLKLQ TPVPSDIEIA RSQTPKNIGD LASEIGIAKS ELEFYGSHKA KVNLEILQRL  60
   61 AHRRDGHYVV VTGITPTPFG EGKSTLTAGL VQALSNLDKL AIACVRQPSQ GPTFGIKGGA 120
  121 AGGGYSQFIP MEEFNLHLTG DIHAITAATN LLAAAIDTRM FHENTQSDAA LYKRLTLVKG 180
  181 NKREFAPVMF RRLKKLGIDK TNPEELTEEE QRKFARLDIE PSTISWNRTL DVNDRFLRKI 240
  241 TIGENPTEKG FTRQTGFDLS VASECMSVLA LATDLKDMRE RLGRMVVASN KSGEPVTADD 300
  301 LGVGGALTVL LKDAIKPTLM QTLEGTPALV HAGPFANISI GASSILADRI ALKLAGTEVD 360
  361 EDAKKEAGYV VTEAGFASDI GMEKFFNIKC RTSGLKPDAI VIVATVQALK LHGGGPPVGP 420
  421 GKPIPEVYKR EDVDLVRKGC ANLAKHISNA RKYGLPVVVA INKFSSDSPN EISAIREEAL 480
  481 AAGATDAVDS NHWAEGGKGA LGVARALINA CENVDSEFRL LYDVHEPIEK KIEIIAKEMY 540
  541 GADGIELSPL AKERLETFTK QGYNNLPICI AKTQYSLSHD PDLKGAPTNF TVPIRDMRLS 600
  601 AGAGFIYPLA AAISTIPGLP TKPAYYNIDI AENGDIVGLS 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1000.0
Match: 1fp7A
Description: Formyltetrahydrofolate synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.64537357529343 bayes_pls_golite062009
nucleic acid binding 2.51683451033161 bayes_pls_golite062009
translation initiation factor activity 2.41232228963167 bayes_pls_golite062009
DNA binding 2.12258000781149 bayes_pls_golite062009
transcription regulator activity 2.09345198747025 bayes_pls_golite062009
lysine N-acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
histone acetyltransferase activity 1.55478124277326 bayes_pls_golite062009
hydrolase activity 1.29060292615008 bayes_pls_golite062009
purine ribonucleotide binding 1.1110976601505 bayes_pls_golite062009
ribonucleotide binding 1.11103644113672 bayes_pls_golite062009
purine nucleotide binding 1.1086792521709 bayes_pls_golite062009
nucleotide binding 1.1060655022247 bayes_pls_golite062009
catalytic activity 1.00104173493322 bayes_pls_golite062009
transcription factor activity 0.887108427603557 bayes_pls_golite062009
hydrogen ion transmembrane transporter activity 0.854899277460172 bayes_pls_golite062009
RNA helicase activity 0.81256037545135 bayes_pls_golite062009
ATP binding 0.80197288940364 bayes_pls_golite062009
adenyl ribonucleotide binding 0.770085840885632 bayes_pls_golite062009
adenyl nucleotide binding 0.751575230566049 bayes_pls_golite062009
RNA-dependent ATPase activity 0.74918137191219 bayes_pls_golite062009
structural constituent of ribosome 0.738234102557832 bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity 0.694120974355463 bayes_pls_golite062009
ATP-dependent RNA helicase activity 0.69117331267457 bayes_pls_golite062009
N-acyltransferase activity 0.581315571752634 bayes_pls_golite062009
N-acetyltransferase activity 0.487240078246257 bayes_pls_golite062009
kinase activity 0.431162005044036 bayes_pls_golite062009
ligase activity 0.417681194526243 bayes_pls_golite062009
inorganic cation transmembrane transporter activity 0.347619818489809 bayes_pls_golite062009
translation regulator activity 0.29096092258568 bayes_pls_golite062009
translation factor activity, nucleic acid binding 0.274994961137851 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 0.250756824614616 bayes_pls_golite062009
acetyltransferase activity 0.190660928077915 bayes_pls_golite062009
protein binding 0.170837278876362 bayes_pls_golite062009
nucleobase, nucleoside, nucleotide kinase activity 0.12351419478929 bayes_pls_golite062009
helicase activity 0.0775311459068899 bayes_pls_golite062009
structural molecule activity 0.0558641287316701 bayes_pls_golite062009
RNA binding 0.0261282189186349 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle