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Protein Overview: SPBC839.16

General Information:
Name(s) found: SPBC839.16 [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • C-1-tetrahydrofolate synthase [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 937 amino acids

    Gene Ontology:
    Cellular Component: cytosol [IDALink to PubMed article]
    Biological Process: folic acid biosynthetic process [IDALink to PubMed article]
    10-formyltetrahydrofolate biosynthetic process [IDALink to PubMed article]
    purine base biosynthetic process [IDALink to PubMed article]
    one-carbon metabolic process [IDALink to PubMed article]
    Molecular Function: ATP binding [IEA]
    formate-tetrahydrofolate ligase activity [IDALink to PubMed article]
    methenyltetrahydrofolate cyclohydrolase activity [IDALink to PubMed article]
    methylenetetrahydrofolate dehydrogenase (NADP+) activity [IDALink to PubMed article]
    single-stranded DNA binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLLEGTSL ARKVREELRE QISSIKSVDP YFNVSLKIIQ VGGREDSNVY VRMKTRAANE  60
   61 AGISCEHVNF PEDITEYDLL LAIKGFNEDP TVHGIIVQLP LPAHINEQII TEAVAPEKDV 120
  121 DGFCETNLGK LTKREGQPLF TACTPKGIMC ILKHYGINVQ GKHAVVIGRS NIVGRPMSIL 180
  181 LEKANATVTL CHSKTESIAD IVRTADIVVA AIGIPHFVKA DWLKKGVVAI DVGINSIPDA 240
  241 TKKSGYRLTG DIDFENAKEV ASAITPVPGS VGPMTVAMLL QNVVESAVRF RKMSRKRKPT 300
  301 LLPLKLQTPV PSDIEIARSQ TPKNIGDLAS EIGIAKSELE FYGSHKAKVN LEILQRLAHR 360
  361 RDGHYVVVTG ITPTPFGEGK STLTAGLVQA LSNLDKLAIA CVRQPSQGPT FGIKGGAAGG 420
  421 GYSQFIPMEE FNLHLTGDIH AITAATNLLA AAIDTRMFHE NTQSDAALYK RLTLVKGNKR 480
  481 EFAPVMFRRL KKLGIDKTNP EELTEEEQRK FARLDIEPST ISWNRTLDVN DRFLRKITIG 540
  541 ENPTEKGFTR QTGFDLSVAS ECMSVLALAT DLKDMRERLG RMVVASNKSG EPVTADDLGV 600
  601 GGALTVLLKD AIKPTLMQTL EGTPALVHAG PFANISIGAS SILADRIALK LAGTEVDEDA 660
  661 KKEAGYVVTE AGFASDIGME KFFNIKCRTS GLKPDAIVIV ATVQALKLHG GGPPVGPGKP 720
  721 IPEVYKREDV DLVRKGCANL AKHISNARKY GLPVVVAINK FSSDSPNEIS AIREEALAAG 780
  781 ATDAVDSNHW AEGGKGALGV ARALINACEN VDSEFRLLYD VHEPIEKKIE IIAKEMYGAD 840
  841 GIELSPLAKE RLETFTKQGY NNLPICIAKT QYSLSHDPDL KGAPTNFTVP IRDMRLSAGA 900
  901 GFIYPLAAAI STIPGLPTKP AYYNIDIAEN GDIVGLS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 110.0 Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
    2 View Details [298..937] PSI-BLAST 1000.0 Formyltetrahydrofolate synthetase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  2.64537357529343 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.51683451033161 bayes_pls_golite062009
  • translation initiation factor activity
    		•  2.41232228963167 bayes_pls_golite062009
  • DNA binding
    		•  2.12258000781149 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • lysine N-acetyltransferase activity
    		•  1.55478124277326 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  1.55478124277326 bayes_pls_golite062009
  • hydrolase activity
    		•  1.29060292615008 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  1.1110976601505 bayes_pls_golite062009
  • ribonucleotide binding
    		•  1.11103644113672 bayes_pls_golite062009
  • purine nucleotide binding
    		•  1.1086792521709 bayes_pls_golite062009
  • nucleotide binding
    		•  1.1060655022247 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription factor activity
    		•  0.887108427603557 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.854899277460172 bayes_pls_golite062009
  • RNA helicase activity
    		•  0.81256037545135 bayes_pls_golite062009
  • ATP binding
    		•  0.80197288940364 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.770085840885632 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.751575230566049 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  0.74918137191219 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.738234102557832 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.694120974355463 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  0.69117331267457 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  0.581315571752634 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  0.487240078246257 bayes_pls_golite062009
  • kinase activity
    		•  0.431162005044036 bayes_pls_golite062009
  • ligase activity
    		•  0.417681194526243 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.347619818489809 bayes_pls_golite062009
  • translation regulator activity
    		•  0.29096092258568 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.274994961137851 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.250756824614616 bayes_pls_golite062009
  • acetyltransferase activity
    		•  0.190660928077915 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleobase, nucleoside, nucleotide kinase activity
    		•  0.12351419478929 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • structural molecule activity
    		•  0.0558641287316701 bayes_pls_golite062009
  • RNA binding
    		•  0.0261282189186349 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle