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Protein Overview: tsc2

General Information:
Name(s) found: tsc2 / SPAC630.13c [Sanger Pombe]
Description(s) found:
Found 18 descriptions.
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  • tuberin [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1339 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    TSC1-TSC2 complex [IPILink to PubMed article]
    Biological Process: regulation of small GTPase mediated signal transduction [IEA]
    regulation of amino acid import [IMPLink to PubMed article]
    regulation of GTPase activity [ICLink to PubMed article]
    regulation of L-arginine import [IGILink to PubMed article][IMPLink to PubMed article]
    TOR signaling pathway [TASLink to PubMed article]
    regulation of intracellular protein transport [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed article]
    positive regulation of GTPase activity [IEA]
    cellular response to nitrogen starvation [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    GTPase activator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNKSLLDLS SEPAIKDTDI LSYFDANLPF KKRHQIVRSI YHGLKYYIYS STSIIQVWQN  60
   61 IQDFISTKND NAAFRELVYN LMMRYVSTQK HLSIIERHTF FQTIEKDPFQ DIAELQLRLK 120
  121 SLSVLTDEGH KISGIENRVG PLLSAWFNQY LQWQSQATEL QGKDADSKLV HLLFFKSLFK 180
  181 FSTNLVKFQW FLVPEPQMLQ LVNSVVQICN HARLEDVVTE VLMFFDSMIR YSVIPKASLY 240
  241 DTVLILCSTY ISTYSYSKLA QSVIFNLISS PVSNLAFENV FNILQYNRSN VNAVRGAVRL 300
  301 MRFLMLQEVK NDAIASITLS SSIEFTEFPL GFNENVDFEI LGTVYLFLRT PSILNRLNFL 360
  361 DWHRILNILM YCSQYLPLKA STSKEAFSKT AAFANIYDRV LDFLDFEALI PLLQQFQVKL 420
  421 VFFLKDVLPV LKPKIRKKLL RLFETYNLIF PCNQYWVFNL EFLLGIYQCK TFDLEDRALL 480
  481 FKLVEDACSV ADENSAPILC SKFLFPVIES FSKESDDCVV SPVYNMLFFL SVNFQNPGLK 540
  541 DCIDHIFQQL ISDTSSVTVR RLATSTLIRL FYYYYDLRDA VPIQETLAKM LEILETPSFP 600
  601 FVSRMLCLQF FLRFRANGTS IYICENIDLN EPFKVLNVDS ELIPAVYPIS DSFVNSATVE 660
  661 KHIWERKEND LIKISNHSTE YGKDFVTFPT SSLLRFYRKS MATESNWTIL MFMITHLADQ 720
  721 ISNRSMFIGA LEEIYNLLDF MCDIVFERVS ISAEIPSNIR KANIMIPILQ NVQMLFVYHD 780
  781 QFSRAQEDEL VSVFFAGLQK WNEACHVSIH SLMLCCYELP VSIRKQLPAI LVTLSRLITK 840
  841 PDLSVHILEF LCSLARLPDL IANFTDADYR QIFAIALKYI QHRDFTKESK DSNDTESILK 900
  901 NSYSSYVLAL AYSVLQIWFL SLRLTERKKF VPWILRGLKL ASEGKPLEDL CLVQYDMMQQ 960
  961 FCYSNSDINN QTSTFVDSDV ESETWIRGNS LFTINVSVNS GFLEAVIRRP TGTTQYTFRN1020
 1021 EASLQKFLWE ENLTSSKALT RGLLCTPSSF VSHFLDPHGI SLYNQPLLLP SNDDSVRRAI1080
 1081 SVFDRIPVIE SLKAGLVYVG YQQRREADIL ANTNPSEDFL TFLNGLGTLF ELKTDQKVFA1140
 1141 GGLDRENDID GAFAYCWKDK VTQMVFHCTT MMPTNIEHDP GCTLKKRHIG NDFVTIIFNE1200
 1201 SGLEYDFDTI PSQFNFVNIV ITPESESIRR TGRQIKFYKV KALTKYDIDF SLFRRYKIVS1260
 1261 SDALPAIVRD VTLNAAVFSH IYHRSAGDYV HIWAERLRQL KRLREKFQAS VLPEDYNLDE1320
 1321 QTKTKLQNGT NFSDFTSYL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..617] FFAS03 0.966 Adaptin beta subunit N-terminal fragment
    2 View Details [618..892] FFAS03 0.968 No description for 2ie3A was found.
    3 View Details [893..941] MSA 1.039992 View MSA. No confident structure predictions are available.
    4 View Details [942..1339] PSI-BLAST 91.154902 Crystal Structure of the Rap1GAP catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein transporter activity
    		•  2.99345877012947 bayes_pls_golite062009
  • binding
    		•  2.96084803796407 bayes_pls_golite062009
  • transporter activity
    		•  1.85346023606579 bayes_pls_golite062009
  • protein binding
    		•  1.61131270705552 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  1.53405403816524 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.51565516399356 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  1.47385808411477 bayes_pls_golite062009
  • protein transmembrane transporter activity
    		•  1.12112006227201 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.957118339467874 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  0.710528717985301 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.409399311301148 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.39311980867126 bayes_pls_golite062009
  • nuclear localization sequence binding
    		•  0.33329769733728 bayes_pls_golite062009
  • DNA binding
    		•  0.318557071875052 bayes_pls_golite062009
  • signal sequence binding
    		•  0.279693431859311 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.109435859778099 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0728493557966827 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0641324729536009 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.0615190129942244 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • GTPase regulator activity
    		•  2.49311721255002 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.47167362062465 bayes_pls_golite062009
  • binding
    		•  2.00485235613612 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.97288713085311 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.7279879291116 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.51920120882303 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.30161391997506 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.27128421841666 bayes_pls_golite062009
  • protein binding
    		•  0.690343310248366 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.83

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle