| Protein: | tsc2 |
| Organism: | Schizosaccharomyces pombe |
| Length: | 1339 amino acids |
| Reference: | Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16 |
Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tsc2.
| Description | E-value | Query Range |
Subject Range |
|
|
1394.0 | [0..41] | [1312..112] |
|
|
1378.0 | [0..41] | [1318..117] |
|
|
1349.0 | [0..13] | [1328..76] |
|
|
1098.0 | [0..35] | [1311..72] |
|
|
1095.0 | [0..18] | [991..42] |
|
|
1085.0 | [0..19] | [991..78] |
|
Region A: Residues: [1-617] |
1 11 21 31 41 51
| | | | | |
1 MNNKSLLDLS SEPAIKDTDI LSYFDANLPF KKRHQIVRSI YHGLKYYIYS STSIIQVWQN 60
61 IQDFISTKND NAAFRELVYN LMMRYVSTQK HLSIIERHTF FQTIEKDPFQ DIAELQLRLK 120
121 SLSVLTDEGH KISGIENRVG PLLSAWFNQY LQWQSQATEL QGKDADSKLV HLLFFKSLFK 180
181 FSTNLVKFQW FLVPEPQMLQ LVNSVVQICN HARLEDVVTE VLMFFDSMIR YSVIPKASLY 240
241 DTVLILCSTY ISTYSYSKLA QSVIFNLISS PVSNLAFENV FNILQYNRSN VNAVRGAVRL 300
301 MRFLMLQEVK NDAIASITLS SSIEFTEFPL GFNENVDFEI LGTVYLFLRT PSILNRLNFL 360
361 DWHRILNILM YCSQYLPLKA STSKEAFSKT AAFANIYDRV LDFLDFEALI PLLQQFQVKL 420
421 VFFLKDVLPV LKPKIRKKLL RLFETYNLIF PCNQYWVFNL EFLLGIYQCK TFDLEDRALL 480
481 FKLVEDACSV ADENSAPILC SKFLFPVIES FSKESDDCVV SPVYNMLFFL SVNFQNPGLK 540
541 DCIDHIFQQL ISDTSSVTVR RLATSTLIRL FYYYYDLRDA VPIQETLAKM LEILETPSFP 600
601 FVSRMLCLQF FLRFRAN
|
| Detection Method: |  |
| Confidence: | 0.966 |
| Match: | 1gw5B |
| Description: | Adaptin beta subunit N-terminal fragment |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| protein transporter activity | 2.99345877012947 | bayes_pls_golite062009 |
| binding | 2.96084803796407 | bayes_pls_golite062009 |
| transporter activity | 1.85346023606579 | bayes_pls_golite062009 |
| protein binding | 1.61131270705552 | bayes_pls_golite062009 |
| hydrogen ion transmembrane transporter activity | 1.53405403816524 | bayes_pls_golite062009 |
| substrate-specific transporter activity | 1.51565516399356 | bayes_pls_golite062009 |
| monovalent inorganic cation transmembrane transporter activity | 1.47385808411477 | bayes_pls_golite062009 |
| protein transmembrane transporter activity | 1.12112006227201 | bayes_pls_golite062009 |
| nucleic acid binding | 0.957118339467874 | bayes_pls_golite062009 |
| transmembrane transporter activity | 0.710528717985301 | bayes_pls_golite062009 |
| transcription regulator activity | 0.409399311301148 | bayes_pls_golite062009 |
| substrate-specific transmembrane transporter activity | 0.39311980867126 | bayes_pls_golite062009 |
| nuclear localization sequence binding | 0.33329769733728 | bayes_pls_golite062009 |
| DNA binding | 0.318557071875052 | bayes_pls_golite062009 |
| signal sequence binding | 0.279693431859311 | bayes_pls_golite062009 |
| nucleoside-triphosphatase activity | 0.109435859778099 | bayes_pls_golite062009 |
| pyrophosphatase activity | 0.0728493557966827 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides | 0.0641324729536009 | bayes_pls_golite062009 |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | 0.0615190129942244 | bayes_pls_golite062009 |
|
Region A: Residues: [618-892] |
1 11 21 31 41 51
| | | | | |
1 GTSIYICENI DLNEPFKVLN VDSELIPAVY PISDSFVNSA TVEKHIWERK ENDLIKISNH 60
61 STEYGKDFVT FPTSSLLRFY RKSMATESNW TILMFMITHL ADQISNRSMF IGALEEIYNL 120
121 LDFMCDIVFE RVSISAEIPS NIRKANIMIP ILQNVQMLFV YHDQFSRAQE DELVSVFFAG 180
181 LQKWNEACHV SIHSLMLCCY ELPVSIRKQL PAILVTLSRL ITKPDLSVHI LEFLCSLARL 240
241 PDLIANFTDA DYRQIFAIAL KYIQHRDFTK ESKDS
|
| Detection Method: | |
| Confidence: | 0.968 |
| Match: | 2ie3A |
| Description: | No description for 2ie3A was found. |
|
Region A: Residues: [893-941] |
1 11 21 31 41 51
| | | | | |
1 NDTESILKNS YSSYVLALAY SVLQIWFLSL RLTERKKFVP WILRGLKLA
|
| Detection Method: | |
Shown below is our most confident prediction for this domain.
Click here to view all matches.
Found no confident structure predictions for this domain.
|
Region A: Residues: [942-1339] |
1 11 21 31 41 51
| | | | | |
1 SEGKPLEDLC LVQYDMMQQF CYSNSDINNQ TSTFVDSDVE SETWIRGNSL FTINVSVNSG 60
61 FLEAVIRRPT GTTQYTFRNE ASLQKFLWEE NLTSSKALTR GLLCTPSSFV SHFLDPHGIS 120
121 LYNQPLLLPS NDDSVRRAIS VFDRIPVIES LKAGLVYVGY QQRREADILA NTNPSEDFLT 180
181 FLNGLGTLFE LKTDQKVFAG GLDRENDIDG AFAYCWKDKV TQMVFHCTTM MPTNIEHDPG 240
241 CTLKKRHIGN DFVTIIFNES GLEYDFDTIP SQFNFVNIVI TPESESIRRT GRQIKFYKVK 300
301 ALTKYDIDFS LFRRYKIVSS DALPAIVRDV TLNAAVFSHI YHRSAGDYVH IWAERLRQLK 360
361 RLREKFQASV LPEDYNLDEQ TKTKLQNGTN FSDFTSYL
|
| Detection Method: | |
| Confidence: | 91.154902 |
| Match: | 1srqA |
| Description: | Crystal Structure of the Rap1GAP catalytic domain |
Matching Structure (courtesy of the PDB): |
|
| Term | Confidence | Notes |
| GTPase regulator activity | 2.49311721255002 | bayes_pls_golite062009 |
| nucleoside-triphosphatase regulator activity | 2.47167362062465 | bayes_pls_golite062009 |
| binding | 2.00485235613612 | bayes_pls_golite062009 |
| enzyme regulator activity | 1.97288713085311 | bayes_pls_golite062009 |
| small GTPase regulator activity | 1.7279879291116 | bayes_pls_golite062009 |
| GTPase activator activity | 1.51920120882303 | bayes_pls_golite062009 |
| Ras GTPase activator activity | 1.30161391997506 | bayes_pls_golite062009 |
| enzyme activator activity | 1.27128421841666 | bayes_pls_golite062009 |
| protein binding | 0.690343310248366 | bayes_pls_golite062009 |
