YRC Public Data Repository - Protein Structure Prediction

Protein:	tsc2
Organism:	Schizosaccharomyces pombe
Length:	1339 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for tsc2.

Description	E-value	Query Range	Subject Range
gi\|42553784, gi\|... - gi\|46125581\|ref\|XP_387344.1\| hypothetical protein FG07168.1 [Gibberella zeae PH-1], gi\|42553784\|gb\|E...	1394.0	[0..41]	[1312..112]
gi\|32405664, gi\|... - gi\|32405664\|ref\|XP_323445.1\| hypothetical protein [Neurospora crassa], gi\|28922396\|gb\|EAA31631.1\| co... gi\|85099898 - gi\|85099898\|ref\|XP_960867.1\| hypothetical protein NCU04105 [Neurospora crassa OR74A]	1378.0	[0..41]	[1318..117]
gi\|49099066, gi\|... - gi\|67540840\|ref\|XP_664194.1\| hypothetical protein AN6590.2 [Aspergillus nidulans FGSC A4], ref\|XP_41...	1349.0	[0..13]	[1328..76]
gi\|68489457, gi\|... - gi\|68489457\|ref\|XP_711446.1\| potential GTPase Activating Protein [Candida albicans SC5314], gi\|46432... orf19.1798 - orf19.1798 CGDID:CAL0001001 Assembly 19, Contig19-10126 (30759, 26284) CDS, reverse complemented, tr...	1098.0	[0..35]	[1311..72]
gi\|86439992, gi\|... - gi\|86439992\|ref\|NP_001034452.1\| tuberous sclerosis 2 isoform 2 [Mus musculus], gi\|38173730\|gb\|AAH607...	1095.0	[0..18]	[991..42]
gi\|68533055 - gi\|68533055\|dbj\|BAE06082.1\| SLC9A3R2 variant protein [Homo sapiens]	1085.0	[0..19]	[991..78]

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Predicted Domain #1

Region A:
Residues: [1-617]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNNKSLLDLS SEPAIKDTDI LSYFDANLPF KKRHQIVRSI YHGLKYYIYS STSIIQVWQN  60
   61 IQDFISTKND NAAFRELVYN LMMRYVSTQK HLSIIERHTF FQTIEKDPFQ DIAELQLRLK 120
  121 SLSVLTDEGH KISGIENRVG PLLSAWFNQY LQWQSQATEL QGKDADSKLV HLLFFKSLFK 180
  181 FSTNLVKFQW FLVPEPQMLQ LVNSVVQICN HARLEDVVTE VLMFFDSMIR YSVIPKASLY 240
  241 DTVLILCSTY ISTYSYSKLA QSVIFNLISS PVSNLAFENV FNILQYNRSN VNAVRGAVRL 300
  301 MRFLMLQEVK NDAIASITLS SSIEFTEFPL GFNENVDFEI LGTVYLFLRT PSILNRLNFL 360
  361 DWHRILNILM YCSQYLPLKA STSKEAFSKT AAFANIYDRV LDFLDFEALI PLLQQFQVKL 420
  421 VFFLKDVLPV LKPKIRKKLL RLFETYNLIF PCNQYWVFNL EFLLGIYQCK TFDLEDRALL 480
  481 FKLVEDACSV ADENSAPILC SKFLFPVIES FSKESDDCVV SPVYNMLFFL SVNFQNPGLK 540
  541 DCIDHIFQQL ISDTSSVTVR RLATSTLIRL FYYYYDLRDA VPIQETLAKM LEILETPSFP 600
  601 FVSRMLCLQF FLRFRAN

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.966
Match:	1gw5B
Description:	Adaptin beta subunit N-terminal fragment
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein transporter activity	2.99345877012947	bayes_pls_golite062009
binding	2.96084803796407	bayes_pls_golite062009
transporter activity	1.85346023606579	bayes_pls_golite062009
protein binding	1.61131270705552	bayes_pls_golite062009
hydrogen ion transmembrane transporter activity	1.53405403816524	bayes_pls_golite062009
substrate-specific transporter activity	1.51565516399356	bayes_pls_golite062009
monovalent inorganic cation transmembrane transporter activity	1.47385808411477	bayes_pls_golite062009
protein transmembrane transporter activity	1.12112006227201	bayes_pls_golite062009
nucleic acid binding	0.957118339467874	bayes_pls_golite062009
transmembrane transporter activity	0.710528717985301	bayes_pls_golite062009
transcription regulator activity	0.409399311301148	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	0.39311980867126	bayes_pls_golite062009
nuclear localization sequence binding	0.33329769733728	bayes_pls_golite062009
DNA binding	0.318557071875052	bayes_pls_golite062009
signal sequence binding	0.279693431859311	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.109435859778099	bayes_pls_golite062009
pyrophosphatase activity	0.0728493557966827	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.0641324729536009	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.0615190129942244	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [618-892]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GTSIYICENI DLNEPFKVLN VDSELIPAVY PISDSFVNSA TVEKHIWERK ENDLIKISNH  60
   61 STEYGKDFVT FPTSSLLRFY RKSMATESNW TILMFMITHL ADQISNRSMF IGALEEIYNL 120
  121 LDFMCDIVFE RVSISAEIPS NIRKANIMIP ILQNVQMLFV YHDQFSRAQE DELVSVFFAG 180
  181 LQKWNEACHV SIHSLMLCCY ELPVSIRKQL PAILVTLSRL ITKPDLSVHI LEFLCSLARL 240
  241 PDLIANFTDA DYRQIFAIAL KYIQHRDFTK ESKDS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	0.968
Match:	2ie3A
Description:	No description for 2ie3A was found.

Predicted Domain #3

Region A:
Residues: [893-941]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDTESILKNS YSSYVLALAY SVLQIWFLSL RLTERKKFVP WILRGLKLA

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [942-1339]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEGKPLEDLC LVQYDMMQQF CYSNSDINNQ TSTFVDSDVE SETWIRGNSL FTINVSVNSG  60
   61 FLEAVIRRPT GTTQYTFRNE ASLQKFLWEE NLTSSKALTR GLLCTPSSFV SHFLDPHGIS 120
  121 LYNQPLLLPS NDDSVRRAIS VFDRIPVIES LKAGLVYVGY QQRREADILA NTNPSEDFLT 180
  181 FLNGLGTLFE LKTDQKVFAG GLDRENDIDG AFAYCWKDKV TQMVFHCTTM MPTNIEHDPG 240
  241 CTLKKRHIGN DFVTIIFNES GLEYDFDTIP SQFNFVNIVI TPESESIRRT GRQIKFYKVK 300
  301 ALTKYDIDFS LFRRYKIVSS DALPAIVRDV TLNAAVFSHI YHRSAGDYVH IWAERLRQLK 360
  361 RLREKFQASV LPEDYNLDEQ TKTKLQNGTN FSDFTSYL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	91.154902
Match:	1srqA
Description:	Crystal Structure of the Rap1GAP catalytic domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
GTPase regulator activity	2.49311721255002	bayes_pls_golite062009
nucleoside-triphosphatase regulator activity	2.47167362062465	bayes_pls_golite062009
binding	2.00485235613612	bayes_pls_golite062009
enzyme regulator activity	1.97288713085311	bayes_pls_golite062009
small GTPase regulator activity	1.7279879291116	bayes_pls_golite062009
GTPase activator activity	1.51920120882303	bayes_pls_golite062009
Ras GTPase activator activity	1.30161391997506	bayes_pls_golite062009
enzyme activator activity	1.27128421841666	bayes_pls_golite062009
protein binding	0.690343310248366	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: