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Protein Overview: ccs1

General Information:
Name(s) found: ccs1 / SPAC22E12.04 [Sanger Pombe]
Description(s) found:
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  • gi|7490943|pir||T38161 hypothetical protein SPAC22E12.04 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19115742|ref|NP_594830.1| metallochaperone Ccs1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1723518|sp|Q10357.1|CCS1_SCHPO RecName: Full=Superoxide dismutase 1 copper chaperone [NCBI NR]
  • gi|1220279|emb|CAA93891.1| metallochaperone Ccs1 [Schizosaccharomyces pombe] [NCBI NR]
  • metallochaperone Ccs1 [Sanger Pombe]
  • (Q10357) Hypothetical protein C22E12.04 in chromosome I [Swiss-Prot]
  • Superoxide dismutase 1 copper chaperone OS=Schizosaccharomyces pombe GN=ccs1 PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE; SIMILAR TO S. CEREVISIAE LYS7P: Q10357; [pompepVF.fasta]
  • PUTATIVE COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE; BY SIMILARITY TO S. CEREVISIAE LYS7: Q10357; [pompepV13]
  • Hypothetical protein C22E12.04 in chromosome I [pompep4896]
  • |||putative copper chaperone for superoxide dismutase [pompepnew.fasta]
  • |||chaperone activity (predicted)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • hypothetical protein [Schizosaccharomyces pombe]gi|1220279|emb|CAA93891.1| SPAC22E12.04 [Schizosaccharomyces pombe]gi|1723518|sp|Q10357|YDB4_SCHPO Hypothetical protein C22E12.04 in chromosome Igi|7490943|pir||T38161 hypothetical protein SPAC22E12.04 - [nrdb_11152004_Chlamydomonas]
  • |ccs1|pccs|metallochaperone |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • |ccs1|pccs|metallochaperone Ccs1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC22E12.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC22E12.04 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Superoxide dismutase 1 copper chaperone [nr-271106-contam.fasta]
  • |ccs1|pccs|superoxide dismutase copper chaperone Ccs1|Schizosaccharomyces pombe|chr 1|||Manual [Other_S_Pombe_12-15-2011_reversed.fasta]
  • Superoxide dismutase 1 copper chaperone OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ccs1 PE=3 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 297 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article][ISSLink to PubMed article]
    mitochondrial inner membrane [ISSLink to PubMed article]
    Biological Process: cellular copper ion homeostasis [IGILink to PubMed article]
    superoxide metabolic process [IEA]
    response to metal ion [IGILink to PubMed article]
    Molecular Function: copper chaperone activity [IDALink to PubMed article]
    superoxide dismutase copper chaperone activity [IGILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFEVEYLIKD CDDVNKNTLE QEFQDLNIED WKWDAATGQL IVKGSVSPSK VLRRLENATS  60
   61 KPILIRGASN KESGVSILYE ANEDITQIPK VYGLCRFIPT EEKIFLDLIA TQLLPNREYT 120
  121 GLVTISGDIS RGLKSAGDSL VTLFNANSNE QGKIVLDKEV SGSLPNWIGH CFVLKCVDDS 180
  181 DSATMGIISR SAGLGQNTKQ ICACTGKSLW TEHAELKSVN EGSSCCSKKD SSPSEKPSCC 240
  241 SQEKKSCCSS KKPSCCSQEK KGCCSTEKTS CCSQEKKSCC TSEKPSCCSN GKSTVCA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..297] PSI-BLAST 28.221849 Copper chaperone for superoxide dismutase, C-terminal domain; Copper chaperone for superoxide dismutase, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • copper-exporting ATPase activity
    		•  5.04749761961029 bayes_pls_golite062009
  • copper-transporting ATPase activity
    		•  5.03252922496602 bayes_pls_golite062009
  • copper-dependent protein binding
    		•  4.95395467138629 bayes_pls_golite062009
  • copper ion binding
    		•  4.91808158964828 bayes_pls_golite062009
  • protein phosphatase 2B binding
    		•  3.97076340458771 bayes_pls_golite062009
  • superoxide dismutase activity
    		•  3.77011290735355 bayes_pls_golite062009
  • oxidoreductase activity, acting on superoxide radicals as acceptor
    		•  3.77011290735355 bayes_pls_golite062009
  • copper chaperone activity
    		•  3.53752588768671 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism
    		•  3.27250923701445 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of ions
    		•  2.98847682261773 bayes_pls_golite062009
  • metallochaperone activity
    		•  2.82622922333955 bayes_pls_golite062009
  • copper ion transmembrane transporter activity
    		•  2.53311528765098 bayes_pls_golite062009
  • superoxide dismutase copper chaperone activity
    		•  2.52817596471383 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.46331862428318 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.41954384727602 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.30916666149383 bayes_pls_golite062009
  • binding
    		•  2.28211284921339 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.0278666635337 bayes_pls_golite062009
  • transition metal ion binding
    		•  1.81903588647517 bayes_pls_golite062009
  • metal ion binding
    		•  1.79413011653575 bayes_pls_golite062009
  • cation binding
    		•  1.79413011653575 bayes_pls_golite062009
  • ion binding
    		•  1.78699219376941 bayes_pls_golite062009
  • transition metal ion transmembrane transporter activity
    		•  1.64083855886256 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  1.63756992236587 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.53883152283038 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  1.39970933331095 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  1.39813577306223 bayes_pls_golite062009
  • cation-transporting ATPase activity
    		•  1.38250427863906 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  1.38072038370649 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  1.38072038370649 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  1.37826353967694 bayes_pls_golite062009
  • transporter activity
    		•  1.33910763967058 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.12504351752996 bayes_pls_golite062009
  • catalytic activity
    		•  1.09233965765942 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.964982981309176 bayes_pls_golite062009
  • ATPase activity
    		•  0.948107394178372 bayes_pls_golite062009
  • hydrolase activity
    		•  0.930068054146566 bayes_pls_golite062009
  • protein binding
    		•  0.916153188966515 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.903757171463128 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.887068390699274 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.884791447137788 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.835595471295029 bayes_pls_golite062009
  • phosphatase binding
    		•  0.761846411630881 bayes_pls_golite062009
  • protein phosphatase binding
    		•  0.76170223416265 bayes_pls_golite062009
  • di-, tri-valent inorganic cation transmembrane transporter activity
    		•  0.704985452118462 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.618042428454534 bayes_pls_golite062009
  • enzyme binding
    		•  0.53808149901487 bayes_pls_golite062009
  • chaperone binding
    		•  0.468633271737412 bayes_pls_golite062009
  • zinc ion binding
    		•  0.25600715352161 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle