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Protein Overview: ubp13

General Information:
Name(s) found: ubp13 / SPAC22G7.04 [Sanger Pombe]
Description(s) found:
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  • gi|7492833|pir||T11614 probable poly(A)-specific ribonuclease (EC 3.1.13.4) - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19113965|ref|NP_593053.1| poly(A)-specific ribonuclease complex subunit Pan2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1175466|sp|Q09798.1|PAN2_SCHPO RecName: Full=PAB-dependent poly(A)-specific ribonuclease subunit pan2; AltName: Full=PAB1P-dependent poly(A)-nuclease; AltName: Full=Ubiquitin carboxyl-terminal hydrolase 13 [NCBI NR]
  • gi|1009454|emb|CAA91128.1| ubiquitin C-terminal hydrolase, poly(A)-specific ribonuclease complex subunit Pan2 (predicted) [Schizosaccharomyces pombe] [NCBI NR]
  • poly(A)-specific ribonuclease complex subunit Pan2 [Sanger Pombe]
  • Hypothetical protein C22G7.04 in chromosome I - Schizosaccharomyces pombe (Fission yeast) [Swiss-Prot]
  • PAB-dependent poly(A)-specific ribonuclease subunit pan2 OS=Schizosaccharomyces pombe GN=ubp13 PE=2 SV=1 [Swiss-Prot]
  • UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; PUTATIVE POLYADENYLATION FACTOR; CONTAINS EXONUCLEASE DOMAIN; SIMILAR TO S. CEREVISIAE PAN2: Q09798; [pompepVF.fasta]
  • PUTATIVE POLYADENYLATION FACTOR; SIMILAR TO S. CEREVISIAE PAN2: Q09798; [pompepV13]
  • Hypothetical protein C22G7.04 in chromosome I [pompep4896]
  • |reserved_name_ubp13||WD repeat protein (SMART) [pompepnew.fasta]
  • |ubp13||WD repeat protein (SMART)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • |ubp13||WD repeat protein |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • putative poly(a)-specific ribonuclease subunit [Schizosaccharomyces pombe]gi|1009454|emb|CAA91128.1| SPAC22G7.04 [Schizosaccharomyces pombe]gi|1175466|sp|Q09798|YAA4_SCHPO Hypothetical protein C22G7.04 in chromosome Igi|7492833|pir||T11614 probable pol [nrdb_11152004_Chlamydomonas]
  • (Q09798) Hypothetical protein C22G7.04 in chromosome I [pompep4896_normal_reversed]
  • |ubp13|pan2|ubiquitin C-terminal hydrolase, poly|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC22G7.04 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC22G7.04 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 1115 amino acids

    Gene Ontology:
    Cellular Component: PAN complex [ISSLink to PubMed article]
    cytoplasm [IDALink to PubMed article][ISSLink to PubMed article]
    Biological Process: mRNA processing [ISSLink to PubMed article]
    postreplication repair [ISSLink to PubMed article]
    ubiquitin-dependent protein catabolic process [IEA]
    Molecular Function: poly(A)-specific ribonuclease activity [ISSLink to PubMed article]
    ubiquitin thiolesterase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAWKEITKT TENDGVSTCS LSSIAFDPYS ELVWTGHKNG QIKSSFGPSL TSYTQFIGHE  60
   61 GPVHQVLPQE RGVFSLSSKS LRLSNRKGTI RWRYHSVPCV QRSMIILYSC FLCSKHAVLI 120
  121 SRDSDCIDYR AMFYQSRNNP EVVIGGYHQK LTVVNAERGI SIHKDKNVSD IFIMRRNRLL 180
  181 CCGSTNGEII LRDPNSFQPV NKVVAHTGTI SDIDTSGNLL LSCGYSLRHG TYMLDPFVKV 240
  241 WDLRNLSSLV PIPFPAGPTI IRMHPKLSTT AVVCSCSGQF HIVDTGNPLD AKLMQIPLTS 300
  301 YLTGMDIAST GDAMVFTDVE DNIHLWSPLE NPSFSDLKLP IQLPNTSTET VQLENNDPLN 360
  361 SIGLPYYKDE LLSSWSKYLI FDVGKPILDS NLLIAKQISE NSHPVPQEIK SFHRNQIIEV 420
  421 PWLNRKLISE GATPKFHSER QKDIMSGNDI EGSASYFEEI EDTISGPDSI PKFYQRPVIK 480
  481 YSKFGIEDFD FGFYNKTKYA GLETDITNSY CNSVLQLLSY VPSFSKAAIS HSLGPCDLME 540
  541 CLLCELGFLF AMLKESTGRN CQATNFLRAF SNSSFAQSLG IVFDDYSDGT FPDSFVIQKF 600
  601 TKFMLTEISR IADYEDKKDG TSFPVSFLLK SFCIPEMQTY RCGICGITSQ KIKSSLYIID 660
  661 LHYPSQQLES ILSFEWLFKM SLDRRVDLPP GWCEYCLAHQ PFLLRSFIRS LPDCLFINTQ 720
  721 VKHHEHWKLW ARKNWLPKKL HLRRVNDTMQ CVSQKISNLD KDQQSLSVYV LRGIIYEIRQ 780
  781 NGEEPHFVST IRVSDNTSSD NPDDNRWYIF NDFLVKEVTE EEALTVHGPW KIPIIVYYEK 840
  841 LDTKIPQWDE VSDYTLLYQP YSLNKNPPIN KIQPLTTDEM LYPKMLVGID SEFVALQQEE 900
  901 TEVRSDGTKS TIKPSKLSLA RVSVLRGEGP NKGLPFIDDY VATDDKVTDY LTEYSGIHPG 960
  961 DLDPDRSPYN VVPLKVAYKK LRLLVNAGCI FVGHGLQKDF RIINLLVPPE QVVDTVDLFF1020
 1021 LSSRQRKLSL KFLAWYLLDE EIQLTEHDSI EDALTALKLY DCYDKLKSQG KLEETLDNIY1080
 1081 EVGRRFKFRP PSVASMSLED RNSYGDESVI SNQTN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..184] PSI-BLAST 72.69897 PAF-AH Holoenzyme: Lis1/Alfa2
    2 View Details [185..376] PSI-BLAST 4.522879 Crystal Structure Of Human Fibroblast Activation Protein alpha
    3 View Details [377..884] PSI-BLAST 60.0 Crystal structure of HAUSP
    4 View Details [885..1115] PSI-BLAST 39.69897 N-terminal exonuclease domain of the epsilon subunit of DNA polymerase III

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • ribonuclease activity
    		•  4.62036729045506 bayes_pls_golite062009
  • poly(A)-specific ribonuclease activity
    		•  4.26301879074656 bayes_pls_golite062009
  • exoribonuclease activity
    		•  3.12138921263133 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  2.99795146290131 bayes_pls_golite062009
  • exonuclease activity
    		•  2.86892175148145 bayes_pls_golite062009
  • nuclease activity
    		•  2.84202779131927 bayes_pls_golite062009
  • hydrolase activity
    		•  2.78602644579272 bayes_pls_golite062009
  • endoribonuclease activity
    		•  2.59247838057313 bayes_pls_golite062009
  • endonuclease activity
    		•  2.57451891632839 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.43032491532703 bayes_pls_golite062009
    		• 2.34629145895727 bayes_pls_golite062009
  • ribonuclease H activity
    		•  2.21066093729724 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  1.94077739152313 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.87431870698721 bayes_pls_golite062009
  • DNA polymerase activity
    		•  1.64519652804477 bayes_pls_golite062009
  • DNA-directed DNA polymerase activity
    		•  1.54576601235316 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  1.46367653485697 bayes_pls_golite062009
  • RNA binding
    		•  1.43166314878142 bayes_pls_golite062009
  • catalytic activity
    		•  1.25233849524628 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.867535868813106 bayes_pls_golite062009
  • endoribonuclease activity, producing 5'-phosphomonoesters
    		•  0.830848153280868 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.782108781904855 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.77421125364834 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.763906045630221 bayes_pls_golite062009
  • binding
    		•  0.715089866064182 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.681014317532767 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  0.64268174969672 bayes_pls_golite062009
  • DNA binding
    		•  0.573012783711078 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  0.48776342704945 bayes_pls_golite062009
  • protein binding
    		•  0.035326007863533 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle