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Protein Overview: cct4

General Information:
Name(s) found: cct4 / SPBC106.06 [Sanger Pombe]
Description(s) found:
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  • pir||T39263 chaperonin subunit cct4 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|5817272|emb|CAB53722.1| chaperonin-containing T-complex delta subunit Cct4 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19111947|ref|NP_595155.1| chaperonin-containing T-complex delta subunit Cct4 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|12644300|sp|P50999.2|TCPD_SCHPO RecName: Full=T-complex protein 1 subunit delta; Short=TCP-1-delta; AltName: Full=CCT-delta [NCBI NR]
  • chaperonin-containing T-complex delta subunit Cct4 [Sanger Pombe]
  • T-complex protein 1 subunit delta OS=Schizosaccharomyces pombe GN=cct4 PE=2 SV=2 [Swiss-Prot]
  • T-COMPLEX PROTEIN 1, DELTA SUBUNIT: O59929;P50999;Q9URV5; [pompepVF.fasta]
  • T-complex protein 1, delta subunit (TCP-1-delta) (CCT-delta) [pompep4896]
  • |cct4||t-complex protein 1, delta subunit [pompepnew.fasta]
  • |cct4||chaperonin-containing T-complex|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • chaperonin-containing T-complex; T-complex protein 1 (delta subunit); chaperone activity; involved in protein folding; involved in actin folding; involved in tubulin folding; essential (PMID 12618370); similar to S. cerevisiae YDL143W [Schizosaccharomyces [nrdb_11152004_Chlamydomonas]
  • (P50999) T-complex protein 1, delta subunit (TCP-1-delta) (CCT-delta) [pompep4896_normal_reversed]
  • |cct4||chaperonin-containing T-complex delta subunit Cct4|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta) [nr-271106-contam.fasta]
  • SPBC106.06 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • T-complex protein 1 subunit delta [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • T-complex protein 1 subunit delta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cct4 PE=2 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 527 amino acids

    Gene Ontology:
    Cellular Component: chaperonin-containing T-complex [IDALink to PubMed article]
    nucleus [IDALink to PubMed article]
    cytoskeleton [ISSLink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: tubulin complex assembly [ICLink to PubMed article]
    cytoskeleton organization [ISSLink to PubMed article]
    protein folding [ISSLink to PubMed article]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    unfolded protein binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSKAATVPVA FQDREKPQEV RLSNIMAARS VADAIRTSLG PKGMDKMIQT GKGEVILTND  60
   61 GATILKHLSV LHPAAKMLVD LSAAQDVEAG DGTTSVVILA GSMLACAEKL LKKGIHPTVI 120
  121 AESFQRAAGF TVDCMKENAL AIELSDRESL LRAATTSLNS KIVSQYSNLL APIAVDAVLK 180
  181 VIDPRVATNV DLKDIRIVKK LGGIIDDTEL IPGLALTQTA VKSAGGPTRI EKANIALIQF 240
  241 QLSPPKPDME NQVVVNDYRQ MDKILKEERQ YLLNMCKKIK KAGANVILIQ KSILRDAVND 300
  301 LALHFLAKLK IMVIKDIERD EVEFICKSTG CKPIADIESF AEDKLGHADL VEETSSSGEK 360
  361 IVKFSGVKNA GKTVSILCRG ANLLTLEEAE RSLHDALCVI RCLVKQRALI AGGGSPEIEA 420
  421 AQRLLEHARQ LEGREAICIR AFSEALEIIP VTLAENAGLN AIQVVTELRS RHANGEKTAG 480
  481 INVRKGIVTN ILEENVLQPL LVNISAIQLA AETTKMIMKI DDITLAR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..527] PSI-BLAST 150.0 Crystal structure of the chaperonin from Thermococcus strain KS-1 (nucleotide-free form of single mutant)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • unfolded protein binding
    		•  9.9038451294995 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  3.6934849790316 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  3.40373598585301 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  3.28982639907979 bayes_pls_golite062009
  • binding
    		•  3.11215702001989 bayes_pls_golite062009
  • protein binding
    		•  2.03574683256805 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.88769858570433 bayes_pls_golite062009
  • ATPase activity
    		•  1.85640607183492 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.81343301131567 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.79412354283105 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.79183933227438 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.67284737458957 bayes_pls_golite062009
  • DNA binding
    		•  1.60256620441721 bayes_pls_golite062009
  • transporter activity
    		•  1.27879339110564 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.08697283907212 bayes_pls_golite062009
  • chaperone binding
    		•  0.91200031047441 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.828920415160435 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.630986103152935 bayes_pls_golite062009
  • hydrolase activity
    		•  0.577900060851977 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.573106450426516 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  0.527748436977659 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.44379130337188 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.280310103153739 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.275534581026027 bayes_pls_golite062009
  • hydrogen-exporting ATPase activity, phosphorylative mechanism
    		•  0.26275673855778 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.252704226951294 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.243984617084631 bayes_pls_golite062009
  • misfolded protein binding
    		•  0.20601711041274 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.205808843369749 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.202279803135899 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.20198255686005 bayes_pls_golite062009
  • catalytic activity
    		•  0.107125378994589 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0778814959589007 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle