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Protein Overview: rga1

General Information:
Name(s) found: rga1 / SPBC3F6.05 [Sanger Pombe]
Description(s) found:
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  • gi|7492137|pir||T40395 LIM domain protein - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|31076878|sp|O43052.1|RGA1_SCHPO RecName: Full=Rho-type GTPase-activating protein 1 [NCBI NR]
  • gi|2924502|emb|CAA17694.1| Rho-type GTPase activating protein Rga1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113535|ref|NP_596743.1| GTPase activating protein Rga1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • GTPase activating protein Rga1 [Sanger Pombe]
  • Rho-type GTPase-activating protein 1 OS=Schizosaccharomyces pombe GN=rga1 PE=1 SV=1 [Swiss-Prot]
  • GTPASE ACTIVATOR; RHOGAP DOMAIN; LIM DOMAIN; INVOLVED IN ACTIN CYTOSKELETAL ORGANIZATION; INVOLVED IN FORMATION OF CELL WALL AND SEPTUM; SIMILAR TO S. CEREVISIAE LRG1: O43052; [pompepVF.fasta]
  • LIM AND RHO-GAP DOMAIN CONTAINING PROTEIN: O43052; [pompepV13]
  • Rho-type GTPase-activating protein 1 [pompep4896]
  • |rga1||GTPase activator [pompepnew.fasta]
  • |rga1||GTPase activating protein|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • lim and Rho-gap domain containing protein [Schizosaccharomyces pombe]gi|2924502|emb|CAA17694.1| SPBC3F6.05 [Schizosaccharomyces pombe]gi|31076878|sp|O43052|RGA1_SCHPO Rho-type GTPase-activating protein 1gi|7492137|pir||T40395 LIM domain protein - fissi [nrdb_11152004_Chlamydomonas]
  • (O43052) Rho-type GTPase-activating protein 1 [pompep4896_normal_reversed]
  • |rga1||Rho-type GTPase activating protein Rga1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • LIM domain protein - fission yeast (Schizosaccharomyces pombe) [nr-271106-contam.fasta]
  • hypothetical protein SPBC3F6.05 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC3F6.05 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Rho-type GTPase-activating protein 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rga1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1150 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cell division site [IDALink to PubMed article]
    cell tip [IDALink to PubMed article]
    cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: regulation of Rho GTPase activity [ISS]
    fungal-type cell wall biogenesis [IMPLink to PubMed article]
    barrier septum formation [IMPLink to PubMed article]
    cell morphogenesis [IMPLink to PubMed article]
    actin cytoskeleton organization [IMPLink to PubMed article]
    actin cortical patch localization [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    Rho GTPase activator activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSQRDAKKDG LLYTTNGVSP TPPKRIPVPS RQNKIEENST TKNFPHSRHT STVAGTEGGS  60
   61 SLSRRHTSAE SRKALPNQQQ LAQSGLLNKE EQQSLKRSDT SVFPKAVRKV SSSKICASCG 120
  121 QVISGQYVRA LGNIYHLECF RCHDCNSLVA SKFFPIDDPT LNKQVPLCET DYFRRLDLLC 180
  181 ASCGMALRGY YITALNKKFH IEHFTCSLCY TVFGPNDSYY EYEGKVYCHY HYSTLFAARC 240
  241 CGCDGPILRQ FVEVYRNGVS QNWHVPCHMI YKFWNVKLCQ KTSIETSKKK DSELSQSQLR 300
  301 KREKHLEQKI FHIWHALSYF EEYTASCISD MLLLVSNGEF TKSVICAQKF IRYIEILFKG 360
  361 IDSLETILSS FHAKSMPYVR EAKLLCKKLV SIFALLAKCH NSDIRDVAIV QDFLSLFTGL 420
  421 AHYLKLLIRI SLTGGLRLEQ DHACKHALPQ FLQTVEEARF VDQEGYDSSS FDMPLNLANA 480
  481 SSDLCYVCHS ALEEDCVLLG EIRCHIGCLS CTKCKYNNRE NYDWARWNNQ TKQIECYLCY 540
  541 TESSNVSNDE PHPSFEYVSR LSQYIYLLRI ALVRLYTILM ENNDSSQRKP LSVDPKQENV 600
  601 SSTVETAKQA ETTASSDSFR KYANTLNDLR HLKSSRNRKA TSNETQSSSN STETSKLSKN 660
  661 VSESGKDKSP HWHSHGGSIT GKSIVEQASS PLERRMDAFD ENRAFTLDDI PKVISEQRNR 720
  721 EHRPNAFRHM PSYTDPSYRK NSGAIYDKND GTQKGLTPKS EDAPIRYLSD LSNLELLFTK 780
  781 HVAVLILHPL VRDYYSLDEL MEMSDLRKGG FWEKFGKAFK GKDAEKKNVK KKGTFGVPLE 840
  841 ILVERNNAQS TVGTGVGVKH IPAFIGNTLA AMKRKDMSVV GVFRKNGNIR RLKELSDMLD 900
  901 VSPDSIDYEQ ETPIQLAALL KKFLRELPDP LLTFKLFGLF ITSSKLESEE ERMRVLHLTI 960
  961 CLLPKGHRDT MEVIFGFLYW VASFSHIDDE VGSKMDIHNL ATVITPNILY SKSNDPVDES1020
 1021 FLAIEAVHLL IENFEKFCEV PREISLLLDD PTLFYNNAAW TSKELYKRCE EIISQMSLDE1080
 1081 RNTPKHTAST KRKRQPIRRV TTNLTSDVPS GSEVADTNSL SSTTKDEASP NSDAQPKPQV1140
 1141 KPQHAVIRDS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..73] PSI-BLAST 14.0 Five-finger GLI1
    2 View Details [74..291] PSI-BLAST 43.522879 No description for 2i13A was found.
    3 View Details [292..624] FFAS03 2.08 Cysteine-rich (intestinal) protein, CRP, CRIP
    4 View Details [625..710] deduced N/A No confident structure predictions are available.
    5 View Details [711..1043] PSI-BLAST 61.522879 Crystal Structure of the Human Beta2-Chimaerin
    6 View Details [1044..1150] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.8684204787273 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.06804702015592 bayes_pls_golite062009
  • DNA binding
    		•  1.80808173029022 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.60971311791582 bayes_pls_golite062009
  • protein binding
    		•  1.30321965120678 bayes_pls_golite062009
  • transcription factor activity
    		•  1.24900170210968 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.445717770012964 bayes_pls_golite062009
  • transcription activator activity
    		•  0.367834529853475 bayes_pls_golite062009
  • transcription factor binding
    		•  0.27835676711169 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  0.189821618942417 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.123912633676406 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.101784288585413 bayes_pls_golite062009
  • receptor activity
    		•  0.0887087342257975 bayes_pls_golite062009
  • actin binding
    		•  0.013566820730057 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.0115212357352044 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  4.58620967349979 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  4.48279904625182 bayes_pls_golite062009
  • binding
    		•  2.79128751898373 bayes_pls_golite062009
  • GTPase regulator activity
    		•  2.70614727793157 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  2.68579854252375 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  2.06038764955701 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.9750017471254 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  1.95738547986197 bayes_pls_golite062009
  • protein binding
    		•  1.29100556128076 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.27693544428588 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.2233434243135 bayes_pls_golite062009
  • myosin heavy chain kinase activity
    		•  1.15190288326422 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  1.09070479183477 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.08577758274384 bayes_pls_golite062009
  • actin binding
    		•  1.02058870188398 bayes_pls_golite062009
  • Rho guanyl-nucleotide exchange factor activity
    		•  0.967362611034944 bayes_pls_golite062009
  • Ras guanyl-nucleotide exchange factor activity
    		•  0.958295643211986 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.717730683557543 bayes_pls_golite062009
  • diacylglycerol binding
    		•  0.61310450668925 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.480348726111787 bayes_pls_golite062009
  • DNA binding
    		•  0.418154636457321 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.298334474872045 bayes_pls_golite062009
  • microfilament motor activity
    		•  0.0044514849726196 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle