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Protein Overview: rad13

General Information:
Name(s) found: rad13 / SPBC3E7.08c [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • DNA repair nuclease Rad13 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1112 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: nucleotide-excision repair, DNA incision, 3'-to lesion [TASLink to PubMed article]
    nucleotide-excision repair [IGILink to PubMed article]
    Molecular Function: magnesium ion binding [IEA]
    DNA binding [IEA]
    endonuclease activity [IEA]
    nuclease activity [IEA]
    single-stranded DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSGLWDIL EPVKRPVKLE TLVNKRLAID ASIWIYQFLK AVRDKEGNQL KSSHVVGFFR  60
   61 RICKLLFFGI KPVFVFDGGA PSLKRQTIQK RQARRLDREE NATVTANKLL ALQMRHQAML 120
  121 LEENNKKATA LANASVQNER QMPSSMTLDN SEIKPVLNQR KNYLKPDPYQ LPEMDVSFDK 180
  181 LGSSYDPRIM SQDELTQYVS SFTKIEDINL FDFSNIDFDS ELFQSLPDTD KYSILSAARL 240
  241 RSRLRMGLSS EQLSEMFPNR MDFSRFQIER LKERNDLTQR LMDFTGMNEF GPSRVVSEKN 300
  301 REYILVKNEG AEGGWALGVI SGSTNNEPII IDDEATKLSS NLIDEDEDEA FYDVPLPSRS 360
  361 HSMNPRELVA AKLKEIKENS FSENQQSDEA DYNVTDDLIL QLATQQSLEE NKKSKELFSL 420
  421 SASEFDKLNS EKKTFEILST DIPAEDSMNS LLNDEENLKL EHVGDVSNDS LAFAEKKHPE 480
  481 NGTSIFMDAL PSASREKKTN DLIDPLPFQP MDWGKSIFFE KLKKPTETFM DSKTDIPSEA 540
  541 PDNSKLVEDT NLHTINATVN IESDLDAAKP GIENPIISPL LPVKDDEKDL DLRELNPLEP 600
  601 FENMKEQADD GTVTNPLNVS SDKAMSVYLL SSENAKDTGD IKSESIDAVL PTLETSSPSL 660
  661 SIPTDFQKEA SPNKGAAALS SKVEPEVVEK LLDEEEEEMI IRMAEEEKEY DRFVSELNQR 720
  721 HETEEWNQEA FEKRLKELKN QKRSEKRDAD EVTQVMIKEC QELLRLFGLP YIVAPQEAEA 780
  781 QCSKLLELKL VDGIVTDDSD VFLFGGTRVY RNMFNQNKFV ELYLMDDMKR EFNVNQMDLI 840
  841 KLAHLLGSDY TMGLSRVGPV LALEILHEFP GDTGLFEFKK WFQRLSTGHA SKNDVNTPVK 900
  901 KRINKLVGKI ILPSEFPNPL VDEAYLHPAV DDSKQSFQWG IPDLDELRQF LMATVGWSKQ 960
  961 RTNEVLLPVI QDMHKKQFVG TQSNLTQFFE GGNTNVYAPR VAYHFKSKRL ENALSSFKNQ1020
 1021 ISNQSPMSEE IQADADAFGE SKGSDELQSR ILRRKKMMAS KNSSDSDSDS EDNFLASLTP1080
 1081 KTNSSSISIE NLPRKTKLST SLLKKPSKRR RK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..497] PSI-BLAST 35.522879 Heavy meromyosin subfragment
    2 View Details [498..688] PSI-BLAST 5.0 No description for 2dfsA was found.
    3 View Details [689..1007] PSI-BLAST 51.30103 Crystal structure of the human FEN1-PCNA complex
    4 View Details [1008..1112] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • flap endonuclease activity
    		•  4.10438637013244 bayes_pls_golite062009
  • exonuclease activity
    		•  3.55065728618765 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  3.45300745776281 bayes_pls_golite062009
  • endonuclease activity
    		•  3.40075034200919 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  3.29138075959109 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  3.25110450559975 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  3.19536858640519 bayes_pls_golite062009
  • nuclease activity
    		•  2.50181033811809 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.45364009363271 bayes_pls_golite062009
  • hydrolase activity
    		•  2.4418166499042 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  2.3324415860722 bayes_pls_golite062009
  • 5'-3' exodeoxyribonuclease activity
    		•  2.26658239783943 bayes_pls_golite062009
  • double-stranded DNA specific exodeoxyribonuclease activity
    		•  2.09057967200253 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  2.0005433655378 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  1.9833086883205 bayes_pls_golite062009
  • 5'-flap endonuclease activity
    		•  1.81850767854435 bayes_pls_golite062009
  • DNA binding
    		•  1.67328600485167 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.61574912542722 bayes_pls_golite062009
  • single-stranded DNA specific exodeoxyribonuclease activity
    		•  1.61167902830399 bayes_pls_golite062009
  • binding
    		•  1.47549397931841 bayes_pls_golite062009
  • damaged DNA binding
    		•  1.42836853175021 bayes_pls_golite062009
  • catalytic activity
    		•  1.37534898662234 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.16717206930423 bayes_pls_golite062009
  • single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
    		•  1.15948049342759 bayes_pls_golite062009
  • endodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.901965019685213 bayes_pls_golite062009
  • protein binding
    		•  0.236485289446406 bayes_pls_golite062009
  • ribonuclease activity
    		•  0.198926730726347 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.176453677293411 bayes_pls_golite062009
  • single-stranded DNA specific 3'-5' exodeoxyribonuclease activity
    		•  0.14861832363159 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.0978227645302046 bayes_pls_golite062009
  • 3'-5'-exodeoxyribonuclease activity
    		•  0.0205129272358 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle