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Protein Overview: upf2

General Information:
Name(s) found: upf2 / SPAC19A8.08 [Sanger Pombe]
Description(s) found:
Found 19 descriptions.
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  • nonsense-mediated decay protein Upf2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1049 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSREEQIKKL NQYLDNRELA FRAKDGDKNI FHTESQLDSS LKKNTAFMKR CKSSLTSENY  60
   61 DSFIKEIKTL SLKKFIPEIT AAIVEGMMKC KATKDILSSV KIVWALNLRF STAFTGPMLA 120
  121 NLYCALYPNP GYSLCHESYF ELKQNENEVS EKDRSSHLLK VRPLLRFLIE FWLNGVVGTP 180
  181 EDFVSYLPST DSNDKKFRKP WFEEQNLKKP LVVLLFNDLM DTRFGFLLLP VLTSLVRTFS 240
  241 CELFTTEDFE DKETLELVNR LNPVVWRTYL RKSLNSYVDK LEVYCQKRKS LFEELNKQYQ 300
  301 EQSIIRADPN NEKFQRLANF SKSIESEFSS YASLSEVLNR KASEDLLELN FMEKASSGTN 360
  361 SVFNASGERS ESANVETAQV WDDREQYFFY EVFPNFNEGS IAEMKSSIYE SSQEGIRSSS 420
  421 ENNKKEDDLK DSTGDLNTTQ VSSRVDNFLL KLPSMVSLEL TNEMALEFYD LNTKASRNRL 480
  481 IKALCTIPRT SSFLVPYYVR LARILSQLSS EFSTSLVDHA RHSFKRMIHR KAKHEYDTRL 540
  541 LIVRYISELT KFQLMPFHMV FECYKLCINE FTPFDLEVLA LLLESCGRFL LRYPETKLQM 600
  601 QSFLEAIQKK KLASALASQD QLVLENALHF VNPPKRGIIV SKKKSLKEEF LYDLIQIRLK 660
  661 DDNVFPTLLL LRKFDWKDDY QILYNTIMEV WNIKYNSLNA LARLLSALYK FHPEFCIHVI 720
  721 DDTLESLFSA VNNSDHVEKQ KRLAQARFIS ELCVIHMLDV RAITNFLFHL LPLEKFESFL 780
  781 TMKASTLTNI NNDMFRLRLI VVVLQTCGPS IIRSKTKKTM LTYLLAYQCY FLIQPEMPLD 840
  841 MLYEFEDVIG YVRPSMKVYM HYEEARNALT ERLQAISDDW EEDDTRPVFQ GANDGDISSN 900
  901 EESVYLPEDI SDESETDEES SGLEESDLLD SEDEDIDNEM QLSRELDEEF ERLTNESLLT 960
  961 RMHEKNPGFD VPLPLRASSL GSPYVTRNEE SASESSHVMF TLLTKRGNKQ RSQYLEIPSH1020
 1021 SSLVRSTKNQ QTEEIMERKR VKEMVLNFE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..430] FFAS03 1.18 Ribonuclease domain of colicin E3; Colicin E3 translocation domain; Colicin E3 receptor domain
    2 View Details [431..643] PSI-BLAST 48.09691 Eukaryotic initiation factor eIF4G
    3 View Details [644..882] PSI-BLAST 76.522879 The structural basis of the interaction between nonsense mediated decay factors UPF2 and UPF3
    4 View Details [883..1049] MSA 3.025983 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.34835981020148 bayes_pls_golite062009
  • protein binding
    		•  0.591747388847465 bayes_pls_golite062009
    2
    Term Confidence Notes
  • RNA binding
    		•  2.11573661150436 bayes_pls_golite062009
  • binding
    		•  1.83406697369076 bayes_pls_golite062009
  • protein binding
    		•  1.04044934052933 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.967597910409065 bayes_pls_golite062009
  • mRNA binding
    		•  0.73831124805124 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0579816100130538 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.022274123463527 bayes_pls_golite062009
    3
    Term Confidence Notes
  • RNA binding
    		•  2.11573661150436 bayes_pls_golite062009
  • binding
    		•  1.83406697369076 bayes_pls_golite062009
  • protein binding
    		•  1.04044934052933 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.967597910409065 bayes_pls_golite062009
  • mRNA binding
    		•  0.73831124805124 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0579816100130538 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.022274123463527 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.92

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle