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Protein Overview: nfs1

General Information:
Name(s) found: nfs1 / SPBC21D10.11c [Sanger Pombe]
Description(s) found:
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  • pir||T11683 probable iron-sulfur cofactor synthesis protein NFS1 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|3560214|emb|CAA20767.1| iron-sulfur cluster assembly protein Nfs1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19112794|ref|NP_596002.1| iron-sulfur cluster assembly protein Nfs1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|13431738|sp|O74351.1|NFS1_SCHPO RecName: Full=Probable cysteine desulfurase, mitochondrial; Flags: Precursor [NCBI NR]
  • iron-sulfur cluster assembly protein Nfs1 [Sanger Pombe]
  • Probable cysteine desulfurase, mitochondrial OS=Schizosaccharomyces pombe GN=SPBC21D10.11c PE=2 SV=1 [Swiss-Prot]
  • PUTATIVE CYSTEINE DESULPHERASE; MITOCHONDRIAL; CATALYSES THE REMOVAL OF CYSTEINE TO PRODUCE ALANINE; PROBABLY SUPPLIES INORGANIC SULPHER FOR IRON SULPHER CLUSTERS: O74351; [pompepVF.fasta]
  • Probable cysteine desulfurase, mitochondrial precursor (EC 4.4.1.-) [pompep4896]
  • |||aminotranferase class V [pompepnew.fasta]
  • Probable cysteine desulfurase, mitochondrial precursor (EC 2.8.1.7) [4896.FASTAC]
  • |||aminotransferase class V|Schizosaccharomyces pombe|chr 2|||Manual [pombe041504.fasta]
  • trna splicing protein [Schizosaccharomyces pombe]gi|3560214|emb|CAA20767.1| SPBC21D10.11c [Schizosaccharomyces pombe]gi|13431738|sp|O74351|NFS1_SCHPO Probable cysteine desulfurase, mitochondrial precursorgi|7492682|pir||T11683 probable iron-sulfur cofa [nrdb_11152004_Chlamydomonas]
  • (O74351) Probable cysteine desulfurase, mitochondrial precursor (EC 4.4.1.-) [pompep4896_normal_reversed]
  • |nfs1||mitochondrial cysteine desulfurase Nfs1|Schizosaccharomyces pombe|chr 2|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Probable cysteine desulfurase, mitochondrial precursor [nr-271106-contam.fasta]
  • hypothetical protein SPBC21D10.11c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPBC21D10.11c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • |nfs1||iron-sulfur cluster assembly protein Nfs1|Schizosaccharomyces pombe|chr 2|||Manual [spombe-190209-contam.fasta]
    • Organism: Schizosaccharomyces pombe
    Length: 498 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISSLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [ISS]
    tRNA wobble uridine modification [ISS]
    cysteine metabolic process [IEA]
    iron-sulfur cluster assembly [ISSLink to PubMed article]
    tRNA thio-modification [ISS]
    Molecular Function: cysteine desulfurase activity [ISS]
    pyridoxal phosphate binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGSLMLSRAR CLLELRSALF FVKRESQDIN NVRQSLGVYG RSFMTSSRMD KPSMSNKPRE  60
   61 QMYGLGNMTA VQEPIPENSL KTVTLDQAQT AASTVTGLHP IYMDFQATSP LDYRVLDSML 120
  121 PFFTGIYGNP HSRTHAYGWE AEKAVENARQ EIASVINADP REIIFTSGAT ESNNAILKGV 180
  181 ARFYKSRKKH LVSVQTEHKC VLDSLRALQE EGFEVTFLPV QTNGLINLDE LRDAIRPDTV 240
  241 CVSVMAVNNE IGVCQPLEEI GKICRQKKVF FHSDAAQGYG KIDIDVNRMN IDLMSISAHK 300
  301 IYGPKGIGAA YVRRRPRVRL EPLISGGGQE RGLRSGTLAP SQVVGFGTAA RICKEEMKYD 360
  361 YAHISKLSQR LIDGLLAIPY TSLNGDPKSR YPGCVNISFN YVEGESLLMG LKNIALSSGS 420
  421 ACTSASLEPS YVLRAIGQSD ENAHSSIRFG IGRFTTEAEI DYAIENVSRQ VSFLRNMSPL 480
  481 WDLVQEGVDL STIEWSQH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..77] MSA 4.497996 View MSA. No confident structure predictions are available.
    2 View Details [78..498] PSI-BLAST 92.154902 Cysteine desulfurase IscS

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
    		•  3.40354781002256 bayes_pls_golite062009
  • glycine dehydrogenase (decarboxylating) activity
    		•  3.40354781002256 bayes_pls_golite062009
  • transferase activity
    		•  2.59075614411581 bayes_pls_golite062009
  • L-aspartate:2-oxoglutarate aminotransferase activity
    		•  2.30133284041702 bayes_pls_golite062009
  • catalytic activity
    		•  2.29878871754893 bayes_pls_golite062009
  • cysteine desulfurase activity
    		•  1.30923778688541 bayes_pls_golite062009
  • transferase activity, transferring nitrogenous groups
    		•  1.28316822767388 bayes_pls_golite062009
  • transaminase activity
    		•  1.24990480711889 bayes_pls_golite062009
  • L-alanine:2-oxoglutarate aminotransferase activity
    		•  1.06988190956423 bayes_pls_golite062009
  • alanine-oxo-acid transaminase activity
    		•  1.06988190956423 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.977210827616757 bayes_pls_golite062009
  • binding
    		•  0.942651665520336 bayes_pls_golite062009
  • ligase activity
    		•  0.827063849687833 bayes_pls_golite062009
  • DNA binding
    		•  0.803965264969424 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.699955808682622 bayes_pls_golite062009
  • carbon-sulfur lyase activity
    		•  0.698312655247044 bayes_pls_golite062009
  • transcription factor activity
    		•  0.597417107954964 bayes_pls_golite062009
  • 5-aminolevulinate synthase activity
    		•  0.54326874956263 bayes_pls_golite062009
  • cystathionine gamma-lyase activity
    		•  0.505859361763689 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.50269055590758 bayes_pls_golite062009
  • cystathionine beta-lyase activity
    		•  0.27933426619091 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  0.271623203801431 bayes_pls_golite062009
  • O-phospho-L-serine:2-oxoglutarate aminotransferase activity
    		•  0.234399054481664 bayes_pls_golite062009
  • RNA binding
    		•  0.222777224430863 bayes_pls_golite062009
  • vitamin B6 binding
    		•  0.16957228630576 bayes_pls_golite062009
  • pyridoxal phosphate binding
    		•  0.16957228630576 bayes_pls_golite062009
  • methyltransferase activity
    		•  0.103986924428507 bayes_pls_golite062009
  • sulfurtransferase activity
    		•  0.0450490929307473 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  0.0254276656964899 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle