Protein Overview: mcs4

General Information:
Name(s) found:	mcs4 / SPBC887.10 [Sanger Pombe]
Description(s) found: Found 22 descriptions. SHOW ALL	two-component response regulator [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	522 amino acids
Gene Ontology:
Cellular Component:	cell division site [IDA] cytoplasm [IDA]
Biological Process:	stress-activated protein kinase signaling pathway [IGI] response to arsenic [IMP] two-component signal transduction system (phosphorelay) [IEA] regulation of two-component signal transduction system (phosphorelay) [IC] cellular response to oxidative stress [IC] regulation of transcription, DNA-dependent [IEA] response to hydrogen peroxide [IMP] regulation of mitotic cell cycle [IMP]
Molecular Function:	protein binding [ISS] two-component response regulator activity [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIWFKKVPD GITSSVILSE DHLVDDLKDA IARKFPIRIS QYYDAPELSI RVVAPPNASS  60
   61 ELQSRELSPN ESILFVMETY YPHGQDFNDA LLVASPDTSV ALRYRSSQLS SSTFESTPPV 120
  121 FSEYPPNIIP TPANETVPRI KQPSIALDSL ESPVSAPSRH QSTYSYKGGP LNYNLRNASR 180
  181 TRSHQTLPSS NVNKTGVLLL PRSSRQQTLA SRPSLPDLTS ADKSQPSDEA ESITRKNSIG 240
  241 MSTRSDESTA EKLAKAEVAT PTNSRSISHS SLYTKQSGTA GVLPAVNADI DAANRMNPDI 300
  301 SSQFPIADNK DPLNADTQAH LGFPSNQIDG IVGTSPVNVL TSPGIGAKAP FASLLEGVIP 360
  361 PINVLIVEDN IINQKILETF MKKRNISSEV AKDGLEALEK WKKKSFHLIL MDIQLPTMSG 420
  421 IEVTQEIRRL ERLNAIGVGA PKLTQPIPEK DQLNENKFQS PVIIVALTAS SLMADRNEAL 480
  481 AAGCNDFLTK PVSLVWLEKK ITEWGCMQAL IDWNGWCRFR GR

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..167]	PSI-BLAST	18.39794	Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
2	View Details	[168..358]	PSI-BLAST	4.69897	Histidine kinase PhoQ domain
3	View Details	[359..522]	PSI-BLAST	28.0	PhoP receiver domain

Functions predicted (by domain):

#

Gene Ontology predictions

1

No functions predicted.

2

Term	Confidence	Notes
protein histidine kinase activity	4.0801989106171	bayes_pls_golite062009
two-component sensor activity	4.05766575937763	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	3.930740609705	bayes_pls_golite062009
two-component response regulator activity	2.85609250646642	bayes_pls_golite062009
protein kinase activity	2.71279142145028	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	2.59313186060787	bayes_pls_golite062009
kinase activity	2.55431033782624	bayes_pls_golite062009
signal transducer activity	2.54232469259941	bayes_pls_golite062009
molecular transducer activity	2.54232469259941	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	2.23056987198541	bayes_pls_golite062009
transferase activity	0.874054982954178	bayes_pls_golite062009
binding	0.861888986648473	bayes_pls_golite062009
catalytic activity	0.441963165592665	bayes_pls_golite062009
transcription regulator activity	0.363939486794255	bayes_pls_golite062009
DNA binding	0.131651654214685	bayes_pls_golite062009
nucleic acid binding	0.040936017783927	bayes_pls_golite062009

3

Term	Confidence	Notes
two-component response regulator activity	6.41182973389827	bayes_pls_golite062009
signal transducer activity	4.14222417297698	bayes_pls_golite062009
molecular transducer activity	4.14222417297698	bayes_pls_golite062009
transcription regulator activity	3.97203966078014	bayes_pls_golite062009
binding	1.92400975854452	bayes_pls_golite062009
DNA binding	1.81181471191047	bayes_pls_golite062009
nucleic acid binding	1.67707797730057	bayes_pls_golite062009
protein histidine kinase activity	1.60632989169905	bayes_pls_golite062009
two-component sensor activity	1.58303578136745	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	1.45748315828993	bayes_pls_golite062009
transcription factor activity	1.19022093158713	bayes_pls_golite062009
protein kinase activity	0.144846352298346	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0408032640298051	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle