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View Structure Prediction Details

Protein: mcs4
Organism: Schizosaccharomyces pombe
Length: 522 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for mcs4.

Description E-value Query
Range
Subject
Range
gi|77918661, gi|... - gi|77918661|ref|YP_356476.1| two component hybrid sensor histidine kinase [Pelobacter carbinolicus D...
205.0 [0..13] [513..461]
gi|117609989, gi... - gi|69256468|ref|ZP_00606017.1| PAS [Magnetococcus sp. MC-1], gi|68247589|gb|EAN29674.1| PAS [Magneto...
205.0 [0..8] [516..639]
gi|86555980, gi|... - gi|86607438|ref|YP_476201.1| sensory box histidine kinase/response regulator [Synechococcus sp. JA-3...
gi|86607438 - gi|86607438|ref|YP_476201.1| sensory box histidine kinase/response regulator [Cyanobacteria bacteriu...
202.0 [0..11] [507..949]
gi|82703807, gi|... - gi|82703807|ref|YP_413373.1| multi-sensor hybrid histidine kinase [Nitrosospira multiformis ATCC 251...
199.0 [0..14] [516..526]
gi|108757295, gi... - gi|108757295|ref|YP_630537.1| sensory box histidine kinase/response regulator [Myxococcus xanthus DK...
197.0 [0..13] [516..372]
gi|189347431, gi... - gi|67919260|ref|ZP_00512843.1| PAS [Chlorobium limicola DSM 245], gi|67783098|gb|EAM42494.1| PAS [Ch...
196.0 [0..14] [505..976]
gi|71838819, gi|... - gi|71838819|ref|ZP_00678575.1| Response regulator receiver:ATP-binding region, ATPase-like:Histidine...
196.0 [0..12] [516..395]
gi|86608001 - gi|86608001|ref|YP_476763.1| sensory box histidine kinase/response regulator [Cyanobacteria bacteriu...
gi|86608001, gi|... - gi|86608001|ref|YP_476763.1| sensory box histidine kinase/response regulator [Synechococcus sp. JA-2...
196.0 [0..13] [504..951]
gi|23475256, gi|... - gi|78356986|ref|YP_388435.1| histidine kinase [Desulfovibrio desulfuricans subsp. desulfuricans str....
196.0 [0..15] [507..4]
gi|114566147, gi... - gi|71540891|ref|ZP_00662714.1| PAS [Syntrophomonas wolfei str. Goettingen], gi|71492412|gb|EAO24717....
196.0 [0..10] [521..918]

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Predicted Domain #1
Region A:
Residues: [1-167]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRIWFKKVPD GITSSVILSE DHLVDDLKDA IARKFPIRIS QYYDAPELSI RVVAPPNASS  60
   61 ELQSRELSPN ESILFVMETY YPHGQDFNDA LLVASPDTSV ALRYRSSQLS SSTFESTPPV 120
  121 FSEYPPNIIP TPANETVPRI KQPSIALDSL ESPVSAPSRH QSTYSYK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.39794
Match: 2c2aA
Description: Structure of the entire cytoplasmic portion of a sensor histidine kinase protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [168-358]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGPLNYNLRN ASRTRSHQTL PSSNVNKTGV LLLPRSSRQQ TLASRPSLPD LTSADKSQPS  60
   61 DEAESITRKN SIGMSTRSDE STAEKLAKAE VATPTNSRSI SHSSLYTKQS GTAGVLPAVN 120
  121 ADIDAANRMN PDISSQFPIA DNKDPLNADT QAHLGFPSNQ IDGIVGTSPV NVLTSPGIGA 180
  181 KAPFASLLEG V

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 4.69897
Match: 1id0A
Description: Histidine kinase PhoQ domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
protein histidine kinase activity 4.0801989106171 bayes_pls_golite062009
two-component sensor activity 4.05766575937763 bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor 3.930740609705 bayes_pls_golite062009
two-component response regulator activity 2.85609250646642 bayes_pls_golite062009
protein kinase activity 2.71279142145028 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 2.59313186060787 bayes_pls_golite062009
kinase activity 2.55431033782624 bayes_pls_golite062009
signal transducer activity 2.54232469259941 bayes_pls_golite062009
molecular transducer activity 2.54232469259941 bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups 2.23056987198541 bayes_pls_golite062009
transferase activity 0.874054982954178 bayes_pls_golite062009
binding 0.861888986648473 bayes_pls_golite062009
catalytic activity 0.441963165592665 bayes_pls_golite062009
transcription regulator activity 0.363939486794255 bayes_pls_golite062009
DNA binding 0.131651654214685 bayes_pls_golite062009
nucleic acid binding 0.040936017783927 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [359-522]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IPPINVLIVE DNIINQKILE TFMKKRNISS EVAKDGLEAL EKWKKKSFHL ILMDIQLPTM  60
   61 SGIEVTQEIR RLERLNAIGV GAPKLTQPIP EKDQLNENKF QSPVIIVALT ASSLMADRNE 120
  121 ALAAGCNDFL TKPVSLVWLE KKITEWGCMQ ALIDWNGWCR FRGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 28.0
Match: 1mvoA
Description: PhoP receiver domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
two-component response regulator activity 6.41182973389827 bayes_pls_golite062009
signal transducer activity 4.14222417297698 bayes_pls_golite062009
molecular transducer activity 4.14222417297698 bayes_pls_golite062009
transcription regulator activity 3.97203966078014 bayes_pls_golite062009
binding 1.92400975854452 bayes_pls_golite062009
DNA binding 1.81181471191047 bayes_pls_golite062009
nucleic acid binding 1.67707797730057 bayes_pls_golite062009
protein histidine kinase activity 1.60632989169905 bayes_pls_golite062009
two-component sensor activity 1.58303578136745 bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor 1.45748315828993 bayes_pls_golite062009
transcription factor activity 1.19022093158713 bayes_pls_golite062009
protein kinase activity 0.144846352298346 bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor 0.0408032640298051 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle