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Protein Overview: mae2

General Information:
Name(s) found: mae2 / SPCC794.12c [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • malic enzyme [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: malate metabolic process [IMPLink to PubMed article]
    tricarboxylic acid cycle [IC]
    pyruvate metabolic process [IMPLink to PubMed article]
    Molecular Function: metal ion binding [IEA]
    NAD or NADH binding [IEA]
    malate dehydrogenase (oxaloacetate-decarboxylating) activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPAGTKEQIE CPLKGVTLLN SPRYNKDTAF TPEERQKFEI SSRLPPIVET LQQQVDRCYD  60
   61 QYKAIGDEPL QKNLYLSQLS VTNQTLFYAL ISQHLIEMIP IIYTPTEGDA IKQFSDIYRY 120
  121 PEGCYLDIDH NDLSYIKQQL SEFGKSDSVE YIIITDSEGI LGIGDQGVGG VLISVAKGHL 180
  181 MTLCAGLDPN RFLPIVLDVG TNNETHRKNH QYMGLRKDRV RGEQYDSFLD NVIKAIREVF 240
  241 PEAFIHFEDF GLANAKRILD HYRPDIACFN DDIQGTGAVA LAAIIGALHV TKSPLTEQRI 300
  301 MIFGAGTAGV GIANQIVAGM VTDGLSLDKA RGNLFMIDRC GLLLERHAKI ATDGQKPFLK 360
  361 KDSDFKEVPS GDINLESAIA LVKPTILLGC SGQPGKFTEK AIREMSKHVE RPIIFPISNP 420
  421 TTLMEAKPDQ IDKWSDGKAL IATGSPLPPL NRNGKKYVIS QCNNALLYPA LGVACVLSRC 480
  481 KLLSDGMLKA ASDALATVPR SLFAADEALL PDLNNAREIS RHIVFAVLKQ AVSEGMSTVD 540
  541 LPKDDAKLKE WIIEREWNPE YKPFV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run dam1 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..565] PSI-BLAST 1000.0 Mitochondrial NAD(P)-dependenent malic enzyme

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • malate dehydrogenase activity
    		•  4.38786524125089 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.09625241707629 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.65338499044318 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.47309297191111 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  1.29842732066898 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  1.27032644348698 bayes_pls_golite062009
  • malic enzyme activity
    		•  1.2147813077436 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  1.01627645289834 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.74536049628503 bayes_pls_golite062009
  • alcohol dehydrogenase activity, zinc-dependent
    		•  0.729242797855749 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.527946013169731 bayes_pls_golite062009
  • DNA binding
    		•  0.525227236870065 bayes_pls_golite062009
  • glutamate dehydrogenase (NADP+) activity
    		•  0.476857036112561 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.459537641913493 bayes_pls_golite062009
  • binding
    		•  0.429102711245135 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.152651308844322 bayes_pls_golite062009
  • malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity
    		•  0.120195861875768 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.78

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle