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Protein Overview: hxk2

General Information:
Name(s) found: hxk2 / SPAC4F8.07c [Sanger Pombe]
Description(s) found:
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  • gi|2330824|emb|CAB11054.1| hexokinase 2 [Schizosaccharomyces pombe] [NCBI NR]
  • pir||S68693 hexokinase (EC 2.7.1.1) 2 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19114777|ref|NP_593865.1| hexokinase 2 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1708362|sp|P50521.1|HXK2_SCHPO RecName: Full=Hexokinase-2 [NCBI NR]
  • gi|1160510|emb|CAA63488.1| hexokinase 2 [Schizosaccharomyces pombe] [NCBI NR]
  • hexokinase 2 [Sanger Pombe]
  • Hexokinase-2 OS=Schizosaccharomyces pombe GN=hxk2 PE=2 SV=1 [Swiss-Prot]
  • HEXOKINASE 2: P50521; [pompepVF.fasta]
  • HEXOKINASE 2 (EC 2.7.1.1): P50521; [pompepV13]
  • Hexokinase 2 (EC 2.7.1.1) [pompep4896]
  • |hxk2||hexokinase 2 (PMID 854983) [pompepnew.fasta]
  • |hxk2||hexokinase 2 (PMID 854983)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • |hxk2||hexokinase 2 |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • hexokinase 2 (EC 2.7.1.1) [Schizosaccharomyces pombe]gi|1160510|emb|CAA63488.1| hexokinase 2 [Schizosaccharomyces pombe]gi|2330824|emb|CAB11054.1| hxk2 [Schizosaccharomyces pombe]gi|1708362|sp|P50521|HXK2_SCHPO Hexokinase 2gi|2130206|pir||S68693 hexok [nrdb_11152004_Chlamydomonas]
  • (P50521) Hexokinase 2 (EC 2.7.1.1) [pompep4896_normal_reversed]
  • |hxk2||hexokinase 2|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • Hexokinase-2 [nr-271106-contam.fasta]
  • hypothetical protein SPAC4F8.07c [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • SPAC4F8.07c [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hexokinase 2 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Hexokinase-2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=hxk2 PE=2 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 455 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: glucose 6-phosphate metabolic process [IDALink to PubMed article]
    glycolysis [IEA]
    fructose 6-phosphate metabolic process [IDALink to PubMed article]
    mannose metabolic process [IDALink to PubMed article]
    Molecular Function: ATP binding [IEA]
    glucokinase activity [IDALink to PubMed article]
    mannokinase activity [IDALink to PubMed article]
    fructokinase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEANFQQAVK KLVNDFEYPT ESLREAVKEF DELRQKGLQK NGEVLAMAPA FISTLPTGAE  60
   61 TGDFLALDFG GTNLRVCWIQ LLGDGKYEMK HSKSVLPREC VRNESVKPII DFMSDHVELF 120
  121 IKEHFPSKFG CPEEEYLPMG FTFSYPANQV SITESYLLRW TKGLNIPEAI NKDFAQFLTE 180
  181 GFKARNLPIR IEAVINDTVG TLVTRAYTSK ESDTFMGIIF GTGTNGAYVE QMNQIPKLAG 240
  241 KCTGDHMLIN MEWGATDFSC LHSTRYDLLL DHDTPNAGRQ IFEKRVGGMY LGELFRRALF 300
  301 HLIKVYNFNE GIFPPSITDA WSLETSVLSR MMVERSAENV RNVLSTFKFR FRSDEEALYL 360
  361 WDAAHAIGRR AARMSAVPIA SLYLSTGRAG KKSDVGVDGS LVEHYPHFVD MLREALRELI 420
  421 GDNEKLISIG IAKDGSGIGA ALCALQAVKE KKGLA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run dam1 No Comments Liu X, et al. (2005)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..455] PSI-BLAST 159.0 Hexokinase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • kinase activity
    		•  2.81480196738665 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.66634930184926 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.47806699612578 bayes_pls_golite062009
  • structural molecule activity
    		•  2.37892721989886 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09111975841662 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84294882554466 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • DNA binding
    		•  1.70014394990425 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  1.69431775343358 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  1.58791290104307 bayes_pls_golite062009
  • glucose binding
    		•  1.58717365638543 bayes_pls_golite062009
  • transferase activity
    		•  1.58048472128722 bayes_pls_golite062009
  • transcription activator activity
    		•  1.35676801272576 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.30214785132007 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.30181101672725 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.27871475799533 bayes_pls_golite062009
  • myosin binding
    		•  1.26046360733002 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  1.18894708772738 bayes_pls_golite062009
  • transcription factor activity
    		•  1.06678984888387 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.908385694796738 bayes_pls_golite062009
  • mannokinase activity
    		•  0.766256764215041 bayes_pls_golite062009
  • actin binding
    		•  0.742062735414161 bayes_pls_golite062009
  • protein kinase activity
    		•  0.659672620542945 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.574998559133169 bayes_pls_golite062009
  • hydrolase activity
    		•  0.474893704700898 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • sugar binding
    		•  0.44352406324938 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.426216374317549 bayes_pls_golite062009
  • ATP binding
    		•  0.39408967688855 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.358452809509562 bayes_pls_golite062009
  • ATPase activity
    		•  0.338933039062396 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • monosaccharide binding
    		•  0.20435276425198 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.173637392484485 bayes_pls_golite062009
  • nucleotide binding
    		•  0.168207023557983 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.104339549630743 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.101742118226005 bayes_pls_golite062009
  • chromatin binding
    		•  0.0489277194984092 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.0304569608189402 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle