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Protein Overview: rqh1

General Information:
Name(s) found: rqh1 / SPAC2G11.12 [Sanger Pombe]
Description(s) found:
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  • pir||S62467 ATP-dependent DNA helicase hus2 - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|19114004|ref|NP_593092.1| RecQ type DNA helicase Rqh1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1684754|emb|CAA70577.1| DNA-helicase [Schizosaccharomyces pombe] [NCBI NR]
  • gi|1175484|sp|Q09811.1|HUS2_SCHPO RecName: Full=ATP-dependent DNA helicase hus2/rqh1 [NCBI NR]
  • gi|1019410|emb|CAA91177.1| RecQ type DNA helicase Rqh1 [Schizosaccharomyces pombe] [NCBI NR]
  • RecQ type DNA helicase Rqh1 [Sanger Pombe]
  • ATP-dependent DNA helicase hus2/rqh1 OS=Schizosaccharomyces pombe GN=rqh1 PE=1 SV=1 [Swiss-Prot]
  • ATP-DEPENDENT RECQ TYPE DNA HELICASE; MEIOTIC RECOMBINATION PROTEIN; CHECKPOINT-DEPENDENT DNA DAMAGE RESPONSE DURING S PHASE; SIMILAR TO S. CEREVISIAE SGS1: Q09811; [pompepVF.fasta]
  • ATP-DEPENDENT DNA HELICASE HUS2; MEIOTIC RECOMBINATION PROTEIN; CHECKPOINT-DEPENDENT DNA DAMAGE RESPONSE DURING S PHASE: Q09811; [pompepV13]
  • ATP-dependent DNA helicase hus2/rqh1 [pompep4896]
  • |hus2|rqh1, rad12|ATP-dependent RecQ type DNA helicase [pompepnew.fasta]
  • |hus2|rqh1, rad12|RecQ type DNA helicase|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • atp-dependent dna helicase hus2 [Schizosaccharomyces pombe]gi|1684754|emb|CAA70577.1| DNA-helicase [Schizosaccharomyces pombe]gi|1019410|emb|CAA91177.1| hus2 [Schizosaccharomyces pombe]gi|1175484|sp|Q09811|HUS2_SCHPO ATP-dependent DNA helicase hus2/rqh [nrdb_11152004_Chlamydomonas]
  • |rqh1|hus2, rad12|RecQ type DNA helicase Rqh1|Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • (Q09811) ATP-dependent DNA helicase hus2/rqh1 [pompep4896_normal_reversed]
  • |rqh1|hus2, rad12, rec9|RecQ type DNA helicase Rqh1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • DNA-helicase [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC2G11.12 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • hypothetical protein SPAC2G11.12 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • ATP-dependent DNA helicase hus2/rqh1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rqh1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 1328 amino acids

    Gene Ontology:
    Cellular Component: nuclear replication fork [ICLink to PubMed article]
    RecQ helicase-Topo III complex [IDALink to PubMed article]
    Biological Process: reciprocal meiotic recombination [IMPLink to PubMed article]
    UV protection [IMPLink to PubMed article]
    recombinational repair [IGILink to PubMed article]
    replication fork processing at rDNA locus [IGILink to PubMed article]
    double-strand break repair via homologous recombination [IGILink to PubMed articleLink to PubMed article]
    chromosome segregation [IMPLink to PubMed article]
    resolution of meiotic recombination intermediates [TASLink to PubMed article]
    telomere maintenance [IGILink to PubMed article][IMPLink to PubMed article]
    negative regulation of mitotic recombination [IMPLink to PubMed article]
    response to DNA damage stimulus [IMPLink to PubMed article]
    DNA unwinding involved in replication [ISSLink to PubMed article]
    maintenance of rDNA [IMPLink to PubMed articleLink to PubMed article]
    resolution of mitotic recombination intermediates [IMPLink to PubMed article]
    replication fork processing [TASLink to PubMed article]
    intra-S DNA damage checkpoint [IDALink to PubMed article]
    mitotic metaphase/anaphase transition [IMPLink to PubMed article]
    Molecular Function: ATP binding [ICLink to PubMed article]
    DNA binding [TASLink to PubMed article]
    protein binding [IPILink to PubMed article]
    ATP-dependent 3'-5' DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVTKTNLNR HLDWFFRESP QKIENVTSPI KTLDFVKVKV SSSDIVVKDS IPHKSKNVFD  60
   61 DFDDGYAIDL TEEHQSSSLN NLKWKDVEGP NILKPIKKIA VPASESEEDF DDVDEEMLRA 120
  121 AEMEVFQSCQ PLAVNTADTT VSHSTSSSNV PRSLNKIHDP SRFIKDNDVE NRIHVSSASK 180
  181 VASISNTSKP NPIVSENPIS ATSVSIEIPI KPKELSNNLP FPRLNNNNTN NNNDNNAIEK 240
  241 RDSASPTPSS VSSQISIDFS TWPHQNLLQY LDILRDEKSE ISDRIIEVME RYPFSSRFKE 300
  301 WIPKRDILSQ KISSVLEVLS NNNNSNNNNG NNGTVPNAKT FFTPPSSITQ QVPFPSTIIP 360
  361 ESTVKENSTR PYVNSHLVAN DKITATPFHS EAVVSPLQSN IRNSDIAEFD EFDIDDADFT 420
  421 FNTTDPINDE SGASSDVVVI DDEEDDIENR PLNQALKASK AAVSNASLLQ SSSLDRPLLG 480
  481 EMKDKNHKVL MPSLDDPMLS YPWSKEVLGC LKHKFHLKGF RKNQLEAING TLSGKDVFIL 540
  541 MPTGGGKSLC YQLPAVIEGG ASRGVTLVIS PLLSLMQDQL DHLRKLNIPS LPLSGEQPAD 600
  601 ERRQVISFLM AKNVLVKLLY VTPEGLASNG AITRVLKSLY ERKLLARIVI DEAHCVSHWG 660
  661 HDFRPDYKQL GLLRDRYQGI PFMALTATAN EIVKKDIINT LRMENCLELK SSFNRPNLFY 720
  721 EIKPKKDLYT ELYRFISNGH LHESGIIYCL SRTSCEQVAA KLRNDYGLKA WHYHAGLEKV 780
  781 ERQRIQNEWQ SGSYKIIVAT IAFGMGVDKG DVRFVIHHSF PKSLEGYYQE TGRAGRDGKP 840
  841 AHCIMFYSYK DHVTFQKLIM SGDGDAETKE RQRQMLRQVI QFCENKTDCR RKQVLAYFGE 900
  901 NFDKVHCRKG CDICCEEATY IKQDMTEFSL QAIKLLKSIS GKATLLQLMD IFRGSKSAKI 960
  961 VENGWDRLEG AGVGKLLNRG DSERLFHHLV SEGVFVEKVE ANRRGFVSAY VVPGRQTIIN1020
 1021 SVLAGKRRII LDVKESSSKP DTSSRSLSRS KTLPALREYQ LKSTTASVDC SIGTREVDEI1080
 1081 YDSQMPPVKP SLIHSRNKID LEELSGQKFM SEYEIDVMTR CLKDLKLLRS NLMAIDDSRV1140
 1141 SSYFTDSVLL SMAKKLPRNV KELKEIHGVS NEKAVNLGPK FLQVIQKFID EKEQNLEGTE1200
 1201 LDPSLQSLDT DYPIDTNALS LDHEQGFSDD SDSVYEPSSP IEEGDEEVDG QRKDILNFMN1260
 1261 SQSLTQTGSV PKRKSTSYTR PSKSYRHKRG STSYSRKRKY STSQKDSRKT SKSANTSFIH1320
 1321 PMVKQNYR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..196] MSA 3.193997 View MSA. No confident structure predictions are available.
    2 View Details [197..391] deduced N/A No confident structure predictions are available.
    3 View Details [392..480] PSI-BLAST 28.0 No description for 2fdcA was found.
    4 View Details [481..1053] PSI-BLAST 94.39794 No description for 2v1xA was found.
    5 View Details [1054..1211] PSI-BLAST 19.0 E. coli RecQ HRDC domain
    6 View Details [1212..1328] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle