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Protein Overview: fep1

General Information:
Name(s) found: fep1 / SPAC23E2.01 [Sanger Pombe]
Description(s) found:
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  • pir||T38291 GATA-type transcription factor family protein Gaf2p - fission yeast (Schizosaccharomyces pombe) [NCBI NR]
  • gi|21064951|gb|AAM29187.1| transcription factor Fep1 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|20302469|emb|CAD30004.1| iron-sensing transcription factor [Schizosaccharomyces pombe] [NCBI NR]
  • gi|19113848|ref|NP_592936.1| iron-sensing transcription factor Fep1 [Schizosaccharomyces pombe 972h-] [NCBI NR]
  • gi|1346083|sp|Q10134.1|FEP1_SCHPO RecName: Full=Iron-sensing transcription factor 1; AltName: Full=Transcription factor gaf2; Short=Gaf-2 [NCBI NR]
  • gi|1167862|emb|CAA93113.1| iron-sensing transcription factor Fep1 [Schizosaccharomyces pombe] [NCBI NR]
  • iron-sensing transcription factor Fep1 [Sanger Pombe]
  • Iron-sensing transcription factor 1 OS=Schizosaccharomyces pombe GN=fep1 PE=1 SV=1 [Swiss-Prot]
  • "PUTATIVE TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN; GATA-TYPE: Q10134; [pompepVF.fasta]
  • GATA-TYPE TRANSCRIPTION FACTOR FAMILY PROTEIN GAF2P: Q10134; [pompepV13]
  • Iron-sensing transcription factor 1 (Transcription factor gaf2) (Gaf-2) [pompep4896]
  • |fep1|gaf2|iron-sensing transcriptional regulator [pompepnew.fasta]
  • |fep1|gaf2|iron-sensing transcriptional regulator|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • GATA-type transcription factor family protein Gaf2p [Schizosaccharomyces pombe]gi|21064951|gb|AAM29187.1| transcription factor Fep1 [Schizosaccharomyces pombe]gi|20302469|emb|CAD30004.1| iron-sensing transcription factor [Schizosaccharomyces pombe]gi|1 [nrdb_11152004_Chlamydomonas]
  • (Q10134) Iron-sensing transcription factor 1 (Transcription factor gaf2) (Gaf-2) [pompep4896_normal_reversed]
  • |fep1|gaf2|iron-sensing transcription factor Fep1|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • hypothetical protein SPAC23E2.01 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • iron-sensing transcription factor [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • SPAC23E2.01 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • transcription factor Fep1 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Iron-sensing transcription factor 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=fep1 PE=1 SV=1 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 564 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed articleLink to PubMed article]
    Biological Process: cellular iron ion homeostasis [TASLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter in response to iron ion starvation [IMPLink to PubMed article]
    gene-specific transcription from RNA polymerase II promoter [RCALink to PubMed article]
    regulation of iron ion transport [IMPLink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    transcription factor activity [IDALink to PubMed article]
    zinc ion binding [IEA]
    protein binding [IPILink to PubMed article]
    protein homodimerization activity [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [RCALink to PubMed article]
    sequence-specific DNA binding [IC]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAKPAPFGQ SCSNCHKTTT SLWRRGPDNS LLCNACGLYQ KHRKHARPVK SEDLKDISPL  60
   61 IQQVCKNGTC AGDGFCNGTG GSASCTGCPA LNNRIRSLNA SKSQSGRKSL SPNPSSVPSS 120
  121 TETKASPTPL ESKPQIVSDT TTETSNGTSR RRSSHNQHED SSPPHEPSVT FCQNCATTNT 180
  181 PLWRRDESGN PICNACGLYY KIHGVHRPVT MKKAIIKRRK RLVFNGNANE SQHNLKRMSS 240
  241 GDSGSSVKQQ STRDGPFSKS FPNGNGHASG NSGEGLAEHG MNTGVLPPAS TFPSYNSNFT 300
  301 GFLPSSFNPS PLMTLSRLAA GEPDNNGKVY YSYGPTQEQS ILPLPENKHE GLPPYQNEYV 360
  361 PNGIRANQVV YPGQLVAVGN DSSKQLSEST TSNTDNNGVA TANQSNPLGM KFHLPPILPV 420
  421 GESVCLPPRT SAKPRIAEGI ASLLNPEEPP SNSDKQPSMS NGPKSEVSPS QSQQAPLIQS 480
  481 STSPVSLQFP PEVQGSNVDK RNYALNVLSQ LRSQHDLMIQ ELHNLNQHIQ QIDEWLRSSD 540
  541 NENMASEHIK SSTPAVVASG ALQT

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..65] FFAS03 2.76 Erythroid transcription factor GATA-1
    2 View Details [66..146] deduced N/A No confident structure predictions are available.
    3 View Details [147..247] PSI-BLAST 5.69897 Erythroid transcription factor GATA-1
    4 View Details [248..330] MSA 1.185991 View MSA. No confident structure predictions are available.
    5 View Details [331..495] MSA 5.185985 View MSA. No confident structure predictions are available.
    6 View Details [496..564] deduced N/A Confident ab initio structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  3.84932768708444 bayes_pls_golite062009
  • DNA binding
    		•  3.45124926204188 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.34875987514951 bayes_pls_golite062009
  • binding
    		•  2.8684204787273 bayes_pls_golite062009
  • transcription factor activity
    		•  2.74592237402384 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.23212813739998 bayes_pls_golite062009
  • transcription activator activity
    		•  1.45965791386122 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.44741411126911 bayes_pls_golite062009
  • protein binding
    		•  1.30321965120678 bayes_pls_golite062009
  • transcription factor binding
    		•  1.22761682002 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.1269808729848 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.11015147180927 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.02819346233483 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.987907067926876 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.551724917261005 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.449959641856445 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.199267983374872 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  4.00967542385368 bayes_pls_golite062009
  • DNA binding
    		•  3.60745514727532 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.47256374293954 bayes_pls_golite062009
  • binding
    		•  2.96409924710655 bayes_pls_golite062009
  • transcription factor activity
    		•  2.90769972671972 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.40923942043513 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.62841402245495 bayes_pls_golite062009
  • transcription activator activity
    		•  1.62405765585032 bayes_pls_golite062009
  • ligand-dependent nuclear receptor activity
    		•  1.49515149729803 bayes_pls_golite062009
  • protein binding
    		•  1.39455913713025 bayes_pls_golite062009
  • transcription factor binding
    		•  1.38523780690867 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.26452462867497 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  1.10242633521642 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.979635034577337 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.68943696300126 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.58115018700114 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.256420113528322 bayes_pls_golite062009
  • receptor activity
    		•  0.126253365586995 bayes_pls_golite062009
  • catalytic activity
    		•  0.101795606736461 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle