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Protein Overview: exo2

General Information:
Name(s) found: exo2 / SPAC17A5.14 [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • exonuclease II Exo2 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 1328 amino acids

    Gene Ontology:
    Cellular Component: perinuclear region of cytoplasm [IEA]
    cytoplasm [IDALink to PubMed article]
    cytoplasmic mRNA processing body [ISSLink to PubMed article]
    cytosol [IDALink to PubMed article]
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IEA]
    rRNA processing [ISSLink to PubMed article]
    mRNA catabolic process [ISSLink to PubMed article]
    karyogamy [IEA]
    Molecular Function: magnesium ion binding [IDALink to PubMed article]
    [NOT]ribonuclease H activity [IDALink to PubMed article]
    RNA binding [IEA]
    double-stranded DNA specific 5'-3' exodeoxyribonuclease activity [IDALink to PubMed article]
    single-stranded DNA specific 5'-3' exodeoxyribonuclease activity [IDALink to PubMed article]
    ribonuclease activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIPKFFRWM SERYPLCSQL IENDRIPEFD NLYLDMNGIL HNCTHKNDDH SSPPLPEEEM  60
   61 YIAIFNYIEH LFEKIKPKKL LYMAVDGCAP RAKMNQQRSR RFRTAKDAHD ARLKAERNGE 120
  121 DFPEEQFDSN CITPGTTFME RVSRQLYYFI HKKVTNDSQW QNIEVIFSGH DCPGEGEHKI 180
  181 MEYIRTQKAQ PSYNPNTRHC LYGLDADLIM LGLLSHDPHF CLLREEVTFG PASRNRSKEL 240
  241 AHQKFYLLHL SLLREYLEFE FQECRSTFTF KYDLEKILDD FILLAFFVGN DFLPHLPGLH 300
  301 INEGALALMF SIYKKVMPSA GGYINEKGVI NMARLELILL ELENFEKEIF KAEVSETKNN 360
  361 GNSDKPSFDF LKYITESTND IKAMTGEQKN YFLQIKKFLS SREPFIDFSA NISSVDQRFL 420
  421 RRLCNDLHLS FSKIIKVDGT HLLRITFRDL EFNDEDEDEI EQDEIERVLQ KYDNIPLLNE 480
  481 EQALKEKNVE KDFIQWKDDY YRSKVGFSYY DEEALKAMAE RYVEGLQWVL FYYYRGCQSW 540
  541 GWYYNYHFAP KISDVLKGLD VKIDFKMGTP FRPFEQLMAV LPARSQALVP PCFRDLMVNS 600
  601 ESPIIDFYPE NFALDQNGKT ASWEAVVIIP FIDETRLIDA LASKDKFLTE EERKRNSFNA 660
  661 PTVFSLAEDY TSFYPSSLPS LFPDLVTRCI QKPYSLPSME GKEYLVGLCP GVFLGAFGMV 720
  721 GFPSFHTLKH KAELVYHGIN VFGNESRNPS VIVNVEDVKS ALTSEQIAMQ YVGKRIFVDW 780
  781 PYLREAYVES AMDESYMYLA SNSTIEKRDL AEIEKSQWGR KCSHKIREYS KRFGVLFGDI 840
  841 SLLLQVRPIK GLEYTREGAL VKIFNESVLE DYPAQLVVEK IAIDDPRFTE REAPPVEVEY 900
  901 PPGTKAFHLG EYNYGRPAQI TGCKDNKLII WLSTAPGLDA QWGRVLVNDS KSKEKYYPSY 960
  961 IVAKLLNIHP LLLSKITSSF LISNGTKREN IGLNLKFDAR NQKVLGFSRK STKGWEFSNK1020
 1021 TVALVKEYIN TFPQLFNILT THATKDNLTV KDCFPKDDTQ QLAAVKHWIK EKGINSLTRV1080
 1081 SLDEDALDSD IIKLIEEKAS TIDSTYQVPK KVFGVPRYAL LKPSQTRGIL HSQEFALGDR1140
 1141 VVYVQDSGKV PIAAYGTVVG IMLHHLDVVF DLPFMSGTTL DGRCSPYHGM QVEVSMVLNV1200
 1201 TNPQFVVNTR AGKNRKTNVS ANNVSQGTDS RLVTKPTSTF PSPPSPPSSS VWNKREHHPK1260
 1261 PFSLHQVPPP ESLIHKSKSK FSKGNHHSTN GTQSIRGRGG KRGKPLRSKE LNRKHDHIVQ1320
 1321 PMGKLQIN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..483] FFAS03 1.15 Crystal structure of the human FEN1-PCNA complex
    2 View Details [484..549] deduced N/A No confident structure predictions are available.
    3 View Details [550..780] MSA 2.087951 View MSA. No confident structure predictions are available.
    4 View Details [781..870] deduced N/A No confident structure predictions are available.
    5 View Details [871..1043] deduced N/A No confident structure predictions are available.
    6 View Details [1044..1217] deduced N/A No confident structure predictions are available.
    7 View Details [1218..1328] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • endonuclease activity
    		•  2.8669665385948 bayes_pls_golite062009
  • hydrolase activity
    		•  2.47801245425307 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.24517620525137 bayes_pls_golite062009
  • nuclease activity
    		•  2.0989149357263 bayes_pls_golite062009
  • exonuclease activity
    		•  1.76587867909916 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  1.74349203224875 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  1.68760157046614 bayes_pls_golite062009
  • ribonuclease activity
    		•  1.49206381939599 bayes_pls_golite062009
  • catalytic activity
    		•  1.27951740231695 bayes_pls_golite062009
  • DNA binding
    		•  1.02247981478192 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.991719217031501 bayes_pls_golite062009
  • binding
    		•  0.829502253184465 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.79417076649627 bayes_pls_golite062009
  • flap endonuclease activity
    		•  0.405877291452351 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.371408632109349 bayes_pls_golite062009
  • exodeoxyribonuclease activity, producing 5'-phosphomonoesters
    		•  0.267787854683683 bayes_pls_golite062009
  • exodeoxyribonuclease activity
    		•  0.260397221344929 bayes_pls_golite062009
  • protein binding
    		•  0.256860561043644 bayes_pls_golite062009
  • ribonuclease H activity
    		•  0.234391225960316 bayes_pls_golite062009
  • endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  0.158336939964254 bayes_pls_golite062009
  • endoribonuclease activity
    		•  0.097472492148219 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle