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Protein Overview: prp43

General Information:
Name(s) found: prp43 / SPBC16H5.10c [Sanger Pombe]
Description(s) found:
Found 21 descriptions.
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  • ATP-dependent RNA helicase Prp43 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 735 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    mitochondrion [ISS]
    spliceosomal complex [ISSLink to PubMed article]
    90S preribosome [ISS]
    Biological Process: RNA splicing, via transesterification reactions [ISSLink to PubMed article]
    spliceosome disassembly [ISSLink to PubMed article]
    ribosome biogenesis [TASLink to PubMed article]
    rRNA processing [ISS]
    Molecular Function: ATP binding [ISSLink to PubMed article]
    ATP-dependent RNA helicase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEPAQKKLRQ ESKNPYLAHL NNGDDSEEVV SSKGLTRRAT TVAQAAKAEE GPNNFFNDKP  60
   61 FSQNYFKILE TRRELPVYQQ REEFLKIYHE NQIIVFVGET GSGKTTQIPQ FVLYDELPHL 120
  121 TNTQIACTQP RRVAAMSVAK RVADEMDVDL GEEVGYNIRF EDCSGPNTLL KYMTDGMLLR 180
  181 EAMTDHMLSR YSCIILDEAH ERTLATDILM GLMKRLATRR PDLKIIVMSA TLDAKKFQKY 240
  241 FFDAPLLAVP GRTYPVEIYY TQEPERDYLE AALRTVLQIH VEEGPGDILV FLTGEEEIED 300
  301 ACRKITLEAD DLVREGAAGP LKVYPLYGSL PPNQQQRIFE PTPEDTKSGY GRKVVISTNI 360
  361 AETSLTIDGI VYVVDPGFSK QKIYNPRIRV ESLLVSPISK ASAQQRAGRA GRTRPGKCFR 420
  421 LYTEEAFRKE LIEQTYPEIL RSNLSSTVLE LKKLGIDDLV HFDYMDPPAP ETMMRALEEL 480
  481 NYLNCLDDNG DLTPLGRKAS EFPLDPNLAV MLIRSPEFYC SNEVLSLTAL LSVPNVFVRP 540
  541 NSARKLADEM RQQFTHPDGD HLTLLNVYHA YKSGEGTADW CWNHFLSHRA LISADNVRKQ 600
  601 LRRTMERQEV ELISTPFDDK NYYVNIRRAL VSGFFMQVAK KSANGKNYVT MKDNQVVSLH 660
  661 PSCGLSVTPE WVVYNEFVLT TKSFIRNVTA IRPEWLIELA PNYYDLDDFD NNKEVKSALQ 720
  721 KVYQMAARSK KNARR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..442] PSI-BLAST 61.69897 No description for 2j0qA was found.
    2 View Details [443..489] PSI-BLAST 10.30103 No description for 2d7dA was found.
    3 View Details [490..583] FFAS03 1.13 No description for 2v8oA was found.
    4 View Details [584..735] Pfam 29.886057 No description for PF07717.7 was found. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
    		• 4.704140727858 bayes_pls_golite062009
  • binding
    		•  2.44689197844883 bayes_pls_golite062009
  • RNA binding
    		•  2.29590582680214 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.57653963868443 bayes_pls_golite062009
  • RNA helicase activity
    		•  1.42791449104435 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.41477043612798 bayes_pls_golite062009
  • RNA-dependent ATPase activity
    		•  1.39335733374328 bayes_pls_golite062009
  • ATP-dependent RNA helicase activity
    		•  1.36724390116598 bayes_pls_golite062009
  • DNA binding
    		•  1.11699929651302 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.989226939888218 bayes_pls_golite062009
  • mRNA binding
    		•  0.76699944561918 bayes_pls_golite062009
  • helicase activity
    		•  0.6191010101321 bayes_pls_golite062009
  • motor activity
    		•  0.61636596887462 bayes_pls_golite062009
  • structural molecule activity
    		•  0.596382945962261 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.461763181659193 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.458831409927227 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.455976987338331 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.422944846459286 bayes_pls_golite062009
  • snRNA binding
    		•  0.418985924846052 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.338958888186454 bayes_pls_golite062009
  • purine NTP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • ATP-dependent helicase activity
    		•  0.29664013896754 bayes_pls_golite062009
  • translation release factor activity
    		•  0.178286731022211 bayes_pls_golite062009
  • translation termination factor activity
    		•  0.151456842619444 bayes_pls_golite062009
  • nucleotide binding
    		•  0.114848452385726 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.10713474095071 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.0916519414118148 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.0915913646217636 bayes_pls_golite062009
  • protein binding
    		•  0.071010918255742 bayes_pls_golite062009
  • transcription factor activity
    		•  0.0434163635422169 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.0272673919333979 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle