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Protein Overview: cut23

General Information:
Name(s) found: cut23 / SPAC6F12.14 [Sanger Pombe]
Description(s) found:
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  • gi|6840799|emb|CAB11101.2| anaphase-promoting complex subunit Apc8 [Schizosaccharomyces pombe] [NCBI NR]
  • gi|31340001|sp|O94556.2|APC8_SCHPO RecName: Full=Anaphase-promoting complex subunit 8; AltName: Full=20S cyclosome/APC complex protein apc8; AltName: Full=Cell untimely torn protein 23 [NCBI NR]
  • gi|19114212|ref|NP_593300.1| anaphase-promoting complex subunit Apc8 [Schizosaccharomyces pombe] [NCBI NR]
  • anaphase-promoting complex subunit Apc8 [Sanger Pombe]
  • (O94556) 20S cyclosome/APC complex protein cut23 (Anaphase promoting factor component 8) (Cell untimely torn protein 23) [Swiss-Prot]
  • (O94556) 20S cyclosome/APC complex protein cut23 (Anaphase promoting factor component 8) [Swiss-Prot]
  • Anaphase-promoting complex subunit 8 OS=Schizosaccharomyces pombe GN=cut23 PE=1 SV=2 [Swiss-Prot]
  • ANAPHASE-PROMOTING COMPLEX (APC); CYCLOSOME; TPR DOMAIN PROTEIN; SIMILAR TO S. CEREVISIAE CDC23: O94556; [pompepVF.fasta]
  • COMPONENT OF THE ANAPHASE-PROMOTING COMPLEX (APC); (CYCLOSOME) YEAST CDC 23 HOMOLOG: O94556; [pompepV13]
  • 20S cyclosome/APC complex protein cut23 (Anaphase promoting factor component 8) [pompep4896]
  • |cut23|apc8|anaphase-promoting complex (APC) (PMID 10526233) [pompepnew.fasta]
  • |cut23|apc8|anaphase-promoting complex (APC) (PMID 10526233)|Schizosaccharomyces pombe|chr 1|||Manual [pombe041504.fasta]
  • subunit of the anaphase promoting complex (cyclosome) yeast cdc 23 homolog [Schizosaccharomyces pombe]gi|6840799|emb|CAB11101.2| SPAC6F12.14 [Schizosaccharomyces pombe]gi|31340001|sp|O94556|CU23_SCHPO 20S cyclosome/APC complex protein cut23 (Anaphase pr [nrdb_11152004_Chlamydomonas]
  • |cut23|apc8|anaphase-promoting complex |Schizosaccharomyces pombe|chr 1|||Manual [pompep2242005.fasta]
  • |cut23|apc8|anaphase-promoting complex subunit Apc8|Schizosaccharomyces pombe|chr 1|||Manual [SGD_S-Pombe_na_10-23-2009_con_reversed.fasta]
  • SPAC6F12.14 [Schizosaccharomyces pombe] [nr-271106-contam.fasta]
  • Anaphase-promoting complex subunit 8 (20S cyclosome/APC complex protein apc8) (Cell untimely torn protein 23) [nr-271106-contam.fasta]
  • hypothetical protein SPAC6F12.14 [Schizosaccharomyces pombe 972h-] [nr-271106-contam.fasta]
  • Anaphase-promoting complex subunit 8 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cut23 PE=1 SV=2 [uniprot_sprot.fasta.20160308]
    • Organism: Schizosaccharomyces pombe
    Length: 565 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    anaphase-promoting complex [TASLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: regulation of mitotic metaphase/anaphase transition [IEA]
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [ICLink to PubMed article]
    mitotic metaphase/anaphase transition [IMPLink to PubMed article]
    protein ubiquitination [ICLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVSLNTMMG VDGLEDQEQL REIRNCLLKC ISECSERGLV YAVRWAAEML NGMNPIEMEH  60
   61 IPFSSTPTGE FDLDPDMANE KLLEVEEKNI YLLAKSYFDC KEFERAAYTL QNCKSSKSIF 120
  121 LRLYSKYLAG EKKSEEENET LLNTNLTLSS TNREFYYISE VLESLHYQGN KDPYLLYLSG 180
  181 VVYRKRKQDS KAIDFLKSCV LKAPFFWSAW LELSLSIDSL ETLTTVVSQL PSTHIMTKIF 240
  241 YVYASHELHQ VNSSAYEKLA EAEIIFPNSR YLKTQRALLT YDSRDFDEAE SLFENILTND 300
  301 PYRLDDMDTY SNVLFVLENK SKLGFLAQVA SSIDKFRPET CSIIGNYYSL LSEHEKAVTY 360
  361 FKRALQLNRN YLSAWTLMGH EYVELKNTHA AIESYRLAVD VNRKDYRAWY GLGQTYEVLD 420
  421 MHFYALYYFQ RATALRPYDQ RMWQALGNCY EKIDRPQEAI KSYKRALLGS QTNSSILVRL 480
  481 GNLYEELQDL NSAASMYKQC IKTEETEISP ETIKARIWLA RWELGKKNYR EAELYLSEVL 540
  541 NGDLELEEAK ALLRELRSRM EHSYD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Lid1-TAP APC complex on iontrap. Unpublished Data

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..169] PSI-BLAST 7.69897 Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
    2 View Details [170..565] PSI-BLAST 48.221849 The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.48382710721672 bayes_pls_golite062009
  • peptidyl-prolyl cis-trans isomerase activity
    		•  1.37631940253114 bayes_pls_golite062009
  • cis-trans isomerase activity
    		•  1.30877296437735 bayes_pls_golite062009
  • catalytic activity
    		•  0.885282592863018 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.476979076197416 bayes_pls_golite062009
  • protein kinase activity
    		•  0.360990174745175 bayes_pls_golite062009
  • isomerase activity
    		•  0.273471323955819 bayes_pls_golite062009
  • protein binding
    		•  0.244588415454215 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.151357793750281 bayes_pls_golite062009
  • phosphoserine binding
    		•  0.13303159942732 bayes_pls_golite062009
  • phosphothreonine binding
    		•  0.13303159942732 bayes_pls_golite062009
  • transcription elongation regulator activity
    		•  0.07678485358361 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.0203433819557555 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  6.63746543212322 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  6.37753885031863 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  5.68162115570289 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  4.89523122092864 bayes_pls_golite062009
  • binding
    		•  2.57186536498101 bayes_pls_golite062009
  • protein binding
    		•  1.83529176977066 bayes_pls_golite062009
  • ligase activity
    		•  1.72049482453565 bayes_pls_golite062009
  • hydrolase activity
    		•  0.619711232527193 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.41706917101675 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.194719472400022 bayes_pls_golite062009
  • DNA binding
    		•  0.17736976899009 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle