Protein Overview: cut23

General Information:
Name(s) found:	cut23 / SPAC6F12.14 [Sanger Pombe]
Description(s) found: Found 19 descriptions. SHOW ALL	anaphase-promoting complex subunit Apc8 [Sanger Pombe]
Organism:	Schizosaccharomyces pombe
Length:	565 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA] anaphase-promoting complex [TAS] spindle pole body [IDA]
Biological Process:	regulation of mitotic metaphase/anaphase transition [IEA] anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IC] mitotic metaphase/anaphase transition [IMP] protein ubiquitination [IC]
Molecular Function:	protein binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVSLNTMMG VDGLEDQEQL REIRNCLLKC ISECSERGLV YAVRWAAEML NGMNPIEMEH  60
   61 IPFSSTPTGE FDLDPDMANE KLLEVEEKNI YLLAKSYFDC KEFERAAYTL QNCKSSKSIF 120
  121 LRLYSKYLAG EKKSEEENET LLNTNLTLSS TNREFYYISE VLESLHYQGN KDPYLLYLSG 180
  181 VVYRKRKQDS KAIDFLKSCV LKAPFFWSAW LELSLSIDSL ETLTTVVSQL PSTHIMTKIF 240
  241 YVYASHELHQ VNSSAYEKLA EAEIIFPNSR YLKTQRALLT YDSRDFDEAE SLFENILTND 300
  301 PYRLDDMDTY SNVLFVLENK SKLGFLAQVA SSIDKFRPET CSIIGNYYSL LSEHEKAVTY 360
  361 FKRALQLNRN YLSAWTLMGH EYVELKNTHA AIESYRLAVD VNRKDYRAWY GLGQTYEVLD 420
  421 MHFYALYYFQ RATALRPYDQ RMWQALGNCY EKIDRPQEAI KSYKRALLGS QTNSSILVRL 480
  481 GNLYEELQDL NSAASMYKQC IKTEETEISP ETIKARIWLA RWELGKKNYR EAELYLSEVL 540
  541 NGDLELEEAK ALLRELRSRM EHSYD

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	None Entered	Lid1-TAP APC complex on iontrap.	Unpublished Data

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

No microscopy data found in the PDR for this protein.

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..169]	PSI-BLAST	7.69897	Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90
2	View Details	[170..565]	PSI-BLAST	48.221849	The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
binding	1.48382710721672	bayes_pls_golite062009
peptidyl-prolyl cis-trans isomerase activity	1.37631940253114	bayes_pls_golite062009
cis-trans isomerase activity	1.30877296437735	bayes_pls_golite062009
catalytic activity	0.885282592863018	bayes_pls_golite062009
transcription regulator activity	0.476979076197416	bayes_pls_golite062009
protein kinase activity	0.360990174745175	bayes_pls_golite062009
isomerase activity	0.273471323955819	bayes_pls_golite062009
protein binding	0.244588415454215	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.151357793750281	bayes_pls_golite062009
phosphoserine binding	0.13303159942732	bayes_pls_golite062009
phosphothreonine binding	0.13303159942732	bayes_pls_golite062009
transcription elongation regulator activity	0.07678485358361	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0203433819557555	bayes_pls_golite062009

2

Term	Confidence	Notes
ubiquitin-protein ligase activity	6.63746543212322	bayes_pls_golite062009
small conjugating protein ligase activity	6.37753885031863	bayes_pls_golite062009
acid-amino acid ligase activity	5.68162115570289	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	4.89523122092864	bayes_pls_golite062009
binding	2.57186536498101	bayes_pls_golite062009
protein binding	1.83529176977066	bayes_pls_golite062009
ligase activity	1.72049482453565	bayes_pls_golite062009
hydrolase activity	0.619711232527193	bayes_pls_golite062009
nucleic acid binding	0.41706917101675	bayes_pls_golite062009
transcription regulator activity	0.194719472400022	bayes_pls_golite062009
DNA binding	0.17736976899009	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.97

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle