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Protein Overview: clr4

General Information:
Name(s) found: clr4 / SPBC428.08c [Sanger Pombe]
Description(s) found:
Found 20 descriptions.
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  • histone H3 methyltransferase Clr4 [Sanger Pombe]
    • Organism: Schizosaccharomyces pombe
    Length: 490 amino acids

    Gene Ontology:
    Cellular Component: mating-type region heterochromatin [NASLink to PubMed article]
    nucleus [IDALink to PubMed article]
    nuclear telomeric heterochromatin [NASLink to PubMed article]
    CLRC ubiquitin ligase complex [IDALink to PubMed article]
    nuclear centromeric heterochromatin [TASLink to PubMed article]
    spindle pole body [IDALink to PubMed article]
    Biological Process: regulation of production of siRNA involved in RNA interference [IMPLink to PubMed article]
    chromatin assembly or disassembly [IEA]
    donor selection [IMPLink to PubMed article]
    chromatin silencing at telomere [TASLink to PubMed article]
    meiotic telomere clustering [IMPLink to PubMed article]
    dynein-driven meiotic oscillatory nuclear movement [IGILink to PubMed article]
    chromatin remodeling [RCALink to PubMed article]
    chromatin silencing at centromere [IMPLink to PubMed article]
    chromatin silencing at rDNA [IMPLink to PubMed article]
    histone methylation [IDALink to PubMed article]
    regulation of Ran protein signal transduction [TASLink to PubMed article]
    chromatin silencing at silent mating-type cassette [IMPLink to PubMed article]
    cellular protein localization [IGILink to PubMed articleLink to PubMed article]
    attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation [IMPLink to PubMed article]
    sphingolipid biosynthetic process [IMPLink to PubMed article]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPILink to PubMed article]
    histone methyltransferase activity (H3-K9 specific) [IDALink to PubMed article]
    chromatin binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSPKQEEYEV ERIVDEKLDR NGAVKLYRIR WLNYSSRSDT WEPPENLSGC SAVLAEWKRR  60
   61 KRRLKGSNSD SDSPHHASNP HPNSRQKHQH QTSKSVPRSQ RFSRELNVKK ENKKVFSSQT 120
  121 TKRQSRKQST ALTTNDTSII LDDSLHTNSK KLGKTRNEVK EESQKRELVS NSIKEATSPK 180
  181 TSSILTKPRN PSKLDSYTHL SFYEKRELFR KKLREIEGPE VTLVNEVDDE PCPSLDFQFI 240
  241 SQYRLTQGVI PPDPNFQSGC NCSSLGGCDL NNPSRCECLD DLDEPTHFAY DAQGRVRADT 300
  301 GAVIYECNSF CSCSMECPNR VVQRGRTLPL EIFKTKEKGW GVRSLRFAPA GTFITCYLGE 360
  361 VITSAEAAKR DKNYDDDGIT YLFDLDMFDD ASEYTVDAQN YGDVSRFFNH SCSPNIAIYS 420
  421 AVRNHGFRTI YDLAFFAIKD IQPLEELTFD YAGAKDFSPV QSQKSQQNRI SKLRRQCKCG 480
  481 SANCRGWLFG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..88] PSI-BLAST 8.09691 Histone methyltransferase clr4, chromo domain
    2 View Details [89..201] deduced N/A No confident structure predictions are available.
    3 View Details [202..490] PSI-BLAST 62.522879 SET domain of Clr4

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription repressor activity
    		•  4.08500855631983 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.64390820819794 bayes_pls_golite062009
  • methylated histone residue binding
    		•  3.42338304360938 bayes_pls_golite062009
  • chromatin binding
    		•  3.1924157640698 bayes_pls_golite062009
  • binding
    		•  3.06758476214113 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.19167058827256 bayes_pls_golite062009
  • DNA binding
    		•  2.05514577638135 bayes_pls_golite062009
  • histone binding
    		•  2.00388175060339 bayes_pls_golite062009
  • protein binding
    		•  1.61683263008775 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.998957812785999 bayes_pls_golite062009
  • general transcriptional repressor activity
    		•  0.75184432495983 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.726970683178132 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.494788451379878 bayes_pls_golite062009
  • RNA binding
    		•  0.460026444989124 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.294457188332415 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.208144053427115 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.16478533243377 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.154199885836329 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.151644275982344 bayes_pls_golite062009
  • catalytic activity
    		•  0.14067200158938 bayes_pls_golite062009
  • transcription activator activity
    		•  0.136090220479238 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • histone methyltransferase activity
    		•  6.64131160914647 bayes_pls_golite062009
  • protein methyltransferase activity
    		•  6.08778683840554 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  5.83932313719163 bayes_pls_golite062009
  • histone methyltransferase activity (H3-K9 specific)
    		•  5.55774492432055 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  3.98411678860954 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  2.69428385009711 bayes_pls_golite062009
  • methyltransferase activity
    		•  2.33114816345072 bayes_pls_golite062009
  • binding
    		•  2.2675356705139 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  2.25175257044903 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.20425750757954 bayes_pls_golite062009
  • chromatin binding
    		•  1.26889182518944 bayes_pls_golite062009
  • protein binding
    		•  0.938282161933492 bayes_pls_golite062009
  • transferase activity
    		•  0.653108419761009 bayes_pls_golite062009
  • RNA binding
    		•  0.589947603398124 bayes_pls_golite062009
  • catalytic activity
    		•  0.414641636618101 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle