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Protein Overview: FBpp0311837, run-PA

General Information:
Name(s) found: FBpp0311837 [FlyBase]
run-PA / FBpp0076971 [FlyBase]
Description(s) found:
Found 30 descriptions.
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  • type=protein; loc=X:join(20565720..20566428,20566838..20567661); ID=FBpp0311837; name=run-PC; parent=FBgn0003300,FBtr0345922; dbxref=FlyBase:FBpp0311837,FlyBase_Annotation_IDs:CG1849-PC; MD5=d026e9640f5133d1da6833834b8f6f33; length=510; release=r5.56; species=Dmel; [FlyBase]
  • The gene runt is referred to in FlyBase by the symbol Dmel\run (CG1849, FBgn0003300). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:20565468..20568353. It has the cytological map location 19E2. There is experimental evidence that it has the molecular function</span>: transcription factor activity; sequence-specific DNA binding; transcription activator activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; axon guidance; dendrite morphogenesis; germ-band extension; eye morphogenesis; positive regulation of gene-specific transcription. 93 alleles are reported. The phenotypes of these alleles are annotated with 28 unique terms, many of which group under: organ system; nervous system; embryonic nervous system; peripheral nervous system; thoracic segment; embryonic segment; abdominal ventral denticle belt; external compound sense organ; cuticle; extended germ band embryo; abdominal segment 7; abdominal segment 8; abdominal segment 10; embryonic neuron; multi-cell-component structure; cephalopharyngeal skeleton. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 510 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IEA][NAS]
    Biological Process: periodic partitioning by pair rule gene [NAS][TAS]
    germ-band extension [IMP][TAS]
    axon guidance [IMP]
    neuroblast fate determination [TAS]
    regulation of transcription, DNA-dependent [IEA]
    sex determination, establishment of X:A ratio [NAS][TAS]
    sex determination [NAS]
    regulation of transcription [IEA]
    regulation of transcription from RNA polymerase II promoter [NAS]
    dendrite morphogenesis [IMP]
    ventral cord development [TAS]
    positive regulation of gene-specific transcription [IDA]
    central nervous system development [TAS]
    eye morphogenesis [IMP]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    Molecular Function: DNA binding [TAS]
    ATP binding [IEA]
    transcription factor activity [IDA]
    protein binding [TAS]
    RNA polymerase II transcription factor activity [NAS]
    transcription regulator activity [NAS]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IDA]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHLPAGPTMV ANNTQVLAAA AAAAAAAAAA VAQGPGPQQS SNATTASAIA INPAQSLANT  60
   61 STHSASSTGS STPDLSTNNT SSSSNATTSP QNSAKMPSSM TDMFASLHEM LQEYHGELAQ 120
  121 TGSPSILCSA LPNHWRSNKS LPGAFKVIAL DDVPDGTLVS IKCGNDENYC GELRNCTTTM 180
  181 KNQVAKFNDL RFVGRSGRGK SFTLTITIAT YPVQIASYSK AIKVTVDGPR EPRSKQSYGY 240
  241 PHPGAFNPFM LNPAWLDAAY MTYGYADYFR HQAAAQAAQV HHPALAKSSA SSVSPNPNPS 300
  301 VATSSSSAVQ PSEYPHPAAA VAAAAGQPAA MMPSPPGAAP ATPYAIPQFP FNHVAAAAAA 360
  361 KAATPHAFHP YNFAAAAGLR ARNAALHHQS EPVHVSPASS RPSSSSPTQQ HVLLKLNTSI 420
  421 ETSSIHEQSA SDGDSDDEQI DVVKSEFDLD KSLDVAPLRM RCDLKAPSAM KPLYHESGPG 480
  481 AVANSRQPSP ETTTKIKSAA VQQKTVWRPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..114] deduced N/A No confident structure predictions are available.
    2 View Details [115..267] PSI-BLAST 46.154902 Acute myeloid leukemia 1 protein (AML1), RUNT domain
    3 View Details [268..330] deduced N/A No confident structure predictions are available.
    4 View Details [331..510] MSA 5.200995 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.13591399970354 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.54158309583174 bayes_pls_golite062009
  • DNA binding
    		•  0.53363287856737 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.3602964037518 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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