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Protein Overview: Taf8-PA

General Information:
Name(s) found: Taf8-PA / FBpp0074288 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene TBP-associated factor 8 is referred to in FlyBase by the symbol Dmel\Taf8 (CG7128, FBgn0022724). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:17996005..17997517. It has the cytological map location 16F7. There is experimental evidence that it has the molecular function</span>: protein binding; RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: transcription initiation from RNA polymerase II promoter; cellular process. 14 alleles are reported. The phenotype of these alleles is annotated with: third instar larva. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 328 amino acids

    Gene Ontology:
    Cellular Component: transcription factor TFIID complex [IDA]
    Biological Process: transcription initiation from RNA polymerase II promoter [IDA]
    cellular process [IMP]
    Molecular Function: protein binding [IPI]
    RNA polymerase II transcription factor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKVEAVTVS NVDPYRRILN KVVSQLLLDK GAGQASNHSL ETLTQMLQAL IWEIGNSAHN  60
   61 YCELSGRTMP TVGDVSLALI NMGISISNLD PYMRKETHVP IPLPPQQTQQ RPLSLLQAGI 120
  121 KAPHPHYVPS YFPPMPDPHA YIRTPTHKQP VTEYEAIREK AACQKRDIEK ALTKFLCKTT 180
  181 ETNNLFPTED NMFPLIACKP AFPPYAAALN PTDQVFDFEE LEYHYLVANR TEDEPSKDDG 240
  241 EEGDSENEEM DGDKSKEEKP ELDIKPNSNT NKAILENPNI DNPYLRAATL PKRSKNCPTP 300
  301 GTMPSRSLAT TAPTIRTPST LEITKTNL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 12.221849 TAF(II)42
    2 View Details [149..328] MSA 2.090979 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • general RNA polymerase II transcription factor activity
    		•  9.25279783093877 bayes_pls_golite062009
  • DNA binding
    		•  4.49118409263799 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.35201412176948 bayes_pls_golite062009
  • transcription regulator activity
    		•  4.08606081850613 bayes_pls_golite062009
  • transcription initiation factor activity
    		•  3.96621818094279 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.28941584139552 bayes_pls_golite062009
  • binding
    		•  3.27510691458843 bayes_pls_golite062009
  • transcription activator activity
    		•  2.58408368884371 bayes_pls_golite062009
  • transcription factor activity
    		•  2.51581622888695 bayes_pls_golite062009
  • protein binding
    		•  2.1291876005999 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.18653213156155 bayes_pls_golite062009
  • transcription factor binding
    		•  1.15204005455906 bayes_pls_golite062009
  • transcription coactivator activity
    		•  1.1297723528047 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.10331930589736 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.01502031330902 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.72554769377984 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0792897588268993 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.0736756545988504 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle