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Protein Overview: Rrp45-PA, FBpp03...

General Information:
Name(s) found: FBpp0310515 [FlyBase]
Rrp45-PA / FBpp0074129 [FlyBase]
Description(s) found:
Found 26 descriptions.
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  • type=protein; loc=X:complement(16683710..16683750,16683806..16684546,16684707..16685163); ID=FBpp0310515; name=Rrp45-PB; parent=FBgn0030789,FBtr0344090; dbxref=FlyBase:FBpp0310515,FlyBase_Annotation_IDs:CG9606-PB; MD5=312f802ba76fa2916508a715be52917c; length=412; release=r5.56; species=Dmel; [FlyBase]
  • The gene Rrp45 is referred to in FlyBase by the symbol Dmel\Rrp45 (CG9606, FBgn0030789). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16683480..16685184. It has the cytological map location 15A8. Based on sequence similarity, it is predicted to have molecular function</span>: 3'-5'-exoribonuclease activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mRNA processing. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 412 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic exosome (RNase complex) [ISS]
    nuclear exosome (RNase complex) [ISS]
    exosome (RNase complex) [ISS]
    Biological Process: mRNA processing [ISS]
    Molecular Function: 3'-5'-exoribonuclease activity [ISS]
    RNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFHNSNFFEP GKSKPERSFV QLAVKQNQRL DGRRSNESRD VELTFGKDWG SVAVSMGDTK  60
   61 VLAQVTCEMG PPALSRPNEG KIHLNVYLGG VAFLDEAHTT HDQRSLKLNS LLERTFRSSR 120
  121 SIDLESLCVA VEKHVWCIRV NVNVLNHDGN LYDASTIATL AALMHFRRPD VWYKDGELRI 180
  181 FKKKEREFIP LLFHHYPVSV TYCVYKSSVQ PILDPTLLEE NAADSVIVLS FNSFQELCSL 240
  241 TAGGTAPTNA RIIMQCARNA AVRCKSLLNF VRKALALDEE CRSQGDQSVD GLVALILNTE 300
  301 HKLSYNKLMG RQKQEQQPPP SEKMQLDNNE SSETPVANEE PSKEESAGAP MDTSDWLPHD 360
  361 EDSQELPMRS EASPSKAGLK GKQSRGKYKA NKKTPPRKQN HSDSEEEAKR YI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..330] PSI-BLAST 68.522879 No description for 2nn6A was found.
    2 View Details [331..412] PSI-BLAST 10.69897 S1 RNA BINDING DOMAIN, NMR, 20 STRUCTURES

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • exoribonuclease activity
    		•  7.55877202113513 bayes_pls_golite062009
  • ribonuclease activity
    		•  7.54644729272203 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  7.5310318714913 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  6.46930372693262 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  4.29895100594643 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  3.83939403332553 bayes_pls_golite062009
  • exonuclease activity
    		•  3.40686901061667 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.86434572018929 bayes_pls_golite062009
  • RNA binding
    		•  2.05527376734941 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  1.90115575554186 bayes_pls_golite062009
  • structural molecule activity
    		•  1.69321127364043 bayes_pls_golite062009
  • hydrolase activity
    		•  1.55476709794855 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.20748032530392 bayes_pls_golite062009
  • mRNA binding
    		•  1.17402119891853 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.05662964529454 bayes_pls_golite062009
  • binding
    		•  0.907487229190259 bayes_pls_golite062009
  • catalytic activity
    		•  0.878454819018611 bayes_pls_golite062009
  • DNA binding
    		•  0.828609700556836 bayes_pls_golite062009
  • nuclease activity
    		•  0.69721312877891 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  0.51810239718467 bayes_pls_golite062009
  • tRNA-specific ribonuclease activity
    		•  0.383567539949931 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0287026367466632 bayes_pls_golite062009
    2
    Term Confidence Notes
  • ribonuclease activity
    		•  7.42330864261751 bayes_pls_golite062009
  • exoribonuclease activity
    		•  6.76241588209982 bayes_pls_golite062009
  • exoribonuclease activity, producing 5'-phosphomonoesters
    		•  6.73428326869965 bayes_pls_golite062009
  • 3'-5'-exoribonuclease activity
    		•  5.13367897180134 bayes_pls_golite062009
  • 3'-5' exonuclease activity
    		•  3.51306349336452 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.194200758646 bayes_pls_golite062009
  • exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
    		•  3.07263153665399 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  2.73968547121328 bayes_pls_golite062009
  • DNA binding
    		•  2.71213098011194 bayes_pls_golite062009
  • exonuclease activity
    		•  2.66053639652924 bayes_pls_golite062009
  • RNA binding
    		•  2.41160981373213 bayes_pls_golite062009
  • binding
    		•  2.24181355929217 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  2.02605441840546 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  1.81524862921454 bayes_pls_golite062009
  • structural molecule activity
    		•  1.81283970647925 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  1.62996999055328 bayes_pls_golite062009
    		• 1.5765009871268 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  1.35850109411274 bayes_pls_golite062009
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  1.35845277283398 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  1.35845277283398 bayes_pls_golite062009
  • exoribonuclease II activity
    		•  1.18248519339188 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.996884322431837 bayes_pls_golite062009
  • hydrolase activity
    		•  0.724860465280978 bayes_pls_golite062009
  • nuclease activity
    		•  0.57381531077345 bayes_pls_golite062009
  • mRNA binding
    		•  0.4162128308402 bayes_pls_golite062009
  • ligase activity
    		•  0.346041081217685 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.32084431704638 bayes_pls_golite062009
  • transcription factor activity
    		•  0.298729064067577 bayes_pls_golite062009
  • translation regulator activity
    		•  0.22908707234671 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  0.179682348023561 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.151650064901878 bayes_pls_golite062009
  • translation initiation factor activity
    		•  0.11625379846973 bayes_pls_golite062009
  • RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009
  • DNA-directed RNA polymerase activity
    		•  0.0740938021136293 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle