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Protein Overview: mei-41-PA

General Information:
Name(s) found: mei-41-PA / FBpp0074047 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene meiotic 41 is referred to in FlyBase by the symbol Dmel\mei-41 (CG4252, FBgn0004367). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:16285794..16293601. It has the cytological map location 14C3. Based on sequence similarity, it is predicted to have molecular function</span>: kinase activity. There is experimental evidence for 12 unique biological process</span> terms, many of which group under: cell cycle; response to DNA damage stimulus; cellular macromolecule metabolic process; M phase of meiotic cell cycle; organelle organization; regulation of biological process; cell cycle process; regulation of cellular component organization; DNA repair; double-strand break repair via synthesis-dependent strand annealing; regulation of developmental process; telomere maintenance; actin filament-based process. 64 alleles are reported. The phenotypes of these alleles are annotated with: cycle 13 embryo; dorsal mesothoracic disc; presumptive oocyte; spindle; cycle 14 embryo. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2517 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of cell shape [IMP]
    DNA repair [TAS]
    mitotic cell cycle checkpoint [TAS]
    reciprocal meiotic recombination [IMP]
    regulation of mitosis [IGI][IMP]
    chromosome condensation [IGI]
    response to radiation [TAS]
    imaginal disc development [TAS]
    actin filament organization [IMP]
    telomere maintenance [IGI]
    meiotic anaphase I [IMP]
    double-strand break repair via synthesis-dependent strand annealing [IMP]
    regulation of syncytial blastoderm mitotic cell cycle [TAS]
    response to DNA damage stimulus [IMP]
    cellularization [TAS]
    meiosis [TAS]
    DNA damage checkpoint [IMP][TAS]
    cell cycle checkpoint [TAS]
    embryonic development via the syncytial blastoderm [TAS]
    oogenesis [TAS]
    double-strand break repair via single-strand annealing [IMP]
    female meiosis chromosome segregation [IMP]
    phosphorylation [NAS]
    Molecular Function: protein kinase activity [NAS]
    protein serine/threonine kinase activity [IEA]
    binding [IEA]
    kinase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTQRKDMWK LLYNHVNRNV SNFSGVYSVI EDILCQEPSL ISCSLVRELH NKFQDTFLLW  60
   61 LLNKLAKCLS ESPDSSECIN LQRKILSSCC SNHPKLFERL VLAYVEAIEE THLQLSSLDL 120
  121 GQLSNERKPA ITVRIFRCDV ECLQEFDPHC AIEDIKVPLE QADMYAKSLL EVLQHAHHIG 180
  181 YATHGDIFSG SLHQALLILK ECDMDTKLAS LNYCHNVLRS QSASSWITNP DVGHYAQLTL 240
  241 EATAIMWSAV AKWLDMGCMT RQELKRLNIT TKLLLEVLHM RARPAHHLGY LLLNEILSLP 300
  301 TAIELDDGLL ETLSSYIQGQ LEHSVVPLEQ LVHLQQLMLS HWHCHPTHLV PILALMGLKQ 360
  361 TEMRSGVVQV LTQSLVEILK KEEVLSKDWQ KLIAILRGFK QLEKLILSQS QHKIAEHEGH 420
  421 IDSSVLAMLP LQCEIIKVAD TNWNNLSMQL VELESKCSAD RRHIHLEICS LLMQITFIRH 480
  481 FLKTQTQHQL LAILQRHLKL SYLCAIRLET PSSVHTQMQS FYAQQYMRLF QSEETQEIFC 540
  541 SNLPQLYISG FIKPEQLMKA LPTINNRSGR AQVIRLLLCS QPGKLSVFKV KDRIELYCPK 600
  601 CRPLPKKLPG IYLGKCKQQL PCPDFSSTNL EMIANDLLFY PDFECIAQHL DLLCFEPNVI 660
  661 LGLLRETEAL QKVSVKVIGQ LVSAMRVRSP EFLEQLANLV LAAIKAMLAK PLTEQNVLQQ 720
  721 RSMLNVLTAI AHMEDNEIWL FHWFKMTFFF LVHTRSLVAQ EAVLAATEMC ASQGLQTIHL 780
  781 WNWYKRDALD LTVRLALNVY LLDGVRFTRS LRALTKMLGF TCVQEFTCKY HRLLTAMVLP 840
  841 HCIVNPLCKG VLVLIAKQMQ KHIGTLFSIS FLRIYTHVFL TEEPELANSC IELVVSCTQS 900
  901 SLQQLMNADV KQTVAELLIY FNRNPTFVMR SFQSLLQLSI GSLEELSSQT ANAEFANFIA 960
  961 ERFLGVITYF ESCLSEPSFE KPLKEETLYS LGQIMRFVGS QHVTQFRFKI IAMLSFVHTL1020
 1021 QEPRLQRICL KIWHIFLHVV NVQELGPSLG RIVATLQPLL ADNESVKQVN DLYEFIILRN1080
 1081 ASMLGTFITD LYFLDRMENV SPSIQKCIRR HTAHLDLKGL AEEENQSPPL VDQLRFLQKH1140
 1141 ITDECLQVRV YALQHLGDLF GRRRPKLNST ILSELPLEPM LEQIVNVLMA GCQHDDSQLQ1200
 1201 MASAKCLGEL GAIDASYLPS NYNFASPQHL PLNILSDDFA VLALTSLCRG YQFQQNTKHV1260
 1261 DSFSLAIQET LAICGISPKE QKKVQLWQSL PARMRQLMEP MLHSCYTCVH RPSTCLQQPL1320
 1321 FGSHYSHNYY EEWAFLWASR LIDYLPSSGR RHLLSSYKPC IKRDSNMLST FYPYILLHAL1380
 1381 LECTTEQRNH IQEEFMAVLQ ANEESSSSVR GRQELGAIKE NAFKQFESRK YAAGIKPLAS1440
 1441 TLVSDRKEDS SRVPRLAGKL CAELLDFLQR WLREWQRIHG RSTGGKPPET IDSNYRKIHE1500
 1501 FLNLIPKLLV SRASYNCGEY ARALSYLESY LEEGEDKSQR LLEQFTFLVE VYGSLRDPDS1560
 1561 VEGAVQVRSY DMSVTQDILV NRLVERQQDM ITSYEQLLSS TDQMQPDHVR AMIDAYLRDT1620
 1621 PKTAQLIADG LWQRLSDRYS DQCFAECKSE LLWRLGSYDE MEELQSNWPA QCSQGCLKLR1680
 1681 RPLTTRIEFD SLLDGMRESV LEELRSCSAV QQHSYANAYD AVLKLHLVHE LHCSQELVEK1740
 1741 LEQDRDEDNQ EKLMKNYFDD WQYRLQIVQP QVRIQESIYS FRRNILAELQ RRLTDRNHLL1800
 1801 PHLKTELARI WLNSAQINRN AGQLQRAQLY ILKAAEYQPS GLFIERAKLL WQKGDQVMAM1860
 1861 NYLEEQLSIM RSGCQGNVKQ LAAEQRHLFF RGKYLQAVYS AESMHLCADA VLKYFQEAIA1920
 1921 VHRQSESCHV QMAQFLEKIL EARQGGKSEP TGEQDDMLIN VMVNYAKSLR YGSEHVYQSM1980
 1981 PRLISLWLDT TESSTNTEQV KKMNDLLTNC CTALPTAVFY TVYSQMLSRL CHPVNDVFTV2040
 2041 LRNVIIKLVE AYPQQSLWML LPHFKSAKAH RIKRCKLVLT DSRLQNSTFQ KLLQDFNSLT2100
 2101 ERLMDLTNKE VTLDRTYKLS DLDTRLSKLC KQPEFSQILL PFEKYMQPTL PLNSDSNSSE2160
 2161 GSHLPANQST VNWFPYQQIY ISGFQESVLI LRSAAKPKKL TIRCSDGKDY DVLVKPKDDL2220
 2221 RRDARLMEFN GLVKRYLHQD APARQRRLHI RTYAVLPFNE ECGLVEWLPN LASYRSICMN2280
 2281 LYAQRRLVMS TRQLQSLAVP LHESIERKRE VFTKQLVPAH PPVFQEWLRQ RFATPHSWYE2340
 2341 ARNTYIRTVA VMSMVGYILG LGDRHGENIL FAEGNGDAVH VDFNCLFNQG ELLPYPEVVP2400
 2401 FRLTHNMIVA MGPLGVEGSF RKCCEITLRL LKQESKTLMS ILRPFVYDVG AQTRKGAATA2460
 2461 KITKDVQRIA DRLQGHVKRQ QANSIPLSTE GQVNFLINEA TKVDNLASMY IGWGAFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] deduced N/A No confident structure predictions are available.
    2 View Details [230..442] deduced N/A No confident structure predictions are available.
    3 View Details [443..626] deduced N/A No confident structure predictions are available.
    4 View Details [627..1301] PSI-BLAST 9.0 Crystal Structure of The Cand1-Cul1-Roc1 Complex
    5 View Details [1302..1440] deduced N/A No confident structure predictions are available.
    6 View Details [1441..1821] PSI-BLAST 15.09691 Heavy meromyosin subfragment
    7 View Details [1822..1886] PSI-BLAST 6.221849 Tropomyosin
    8 View Details [1887..2517] PSI-BLAST 69.39794 Phoshoinositide 3-kinase (PI3K) helical domain; Phoshoinositide 3-kinase (PI3K); Phoshoinositide 3-kinase (PI3K), catalytic domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.72717267135753 bayes_pls_golite062009
  • protein binding
    		•  1.01840651819417 bayes_pls_golite062009
  • kinase activity
    		•  0.0760276596533398 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.0674767831653993 bayes_pls_golite062009
  • transferase activity
    		•  0.0525163357236478 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.025201457801308 bayes_pls_golite062009
  • catalytic activity
    		•  0.0114279309788371 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • protein kinase activity
    		•  4.02689842795549 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.90280755052039 bayes_pls_golite062009
  • kinase activity
    		•  3.79479290566599 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.52418803498373 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  3.25689179819529 bayes_pls_golite062009
  • transferase activity
    		•  2.77204178459065 bayes_pls_golite062009
  • catalytic activity
    		•  1.58699080719302 bayes_pls_golite062009
  • binding
    		•  1.4090115174802 bayes_pls_golite062009
  • ATP binding
    		•  1.17595199896949 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  1.14937361489985 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  1.12019766280871 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.92069223793838 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.91856284481973 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.89187631975697 bayes_pls_golite062009
  • nucleotide binding
    		•  0.88568566446713 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.64449050025422 bayes_pls_golite062009
  • signal transducer activity
    		•  0.64449050025422 bayes_pls_golite062009
  • protein binding
    		•  0.507179243841744 bayes_pls_golite062009
  • receptor signaling protein serine/threonine kinase activity
    		•  0.39548279667137 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  0.33236349563013 bayes_pls_golite062009
  • receptor signaling protein activity
    		•  0.2696429722379 bayes_pls_golite062009
  • phospholipid binding
    		•  0.11116435936349 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle