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Protein Overview: exd-PB, exd-PA, ...

General Information:
Name(s) found: FBpp0305515 [FlyBase]
FBpp0305514 [FlyBase]
exd-PB / FBpp0073942 [FlyBase]
exd-PA / FBpp0073940 [FlyBase]
Description(s) found:
Found 63 descriptions.
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  • type=protein; loc=X:join(15887542..15887806,15887998..15888316,15888380..15888638,15888718..15889005); ID=FBpp0305515; name=exd-PE; parent=FBgn0000611,FBtr0333323; dbxref=REFSEQ:NP_001259593,GB_protein:AGB95435,FlyBase:FBpp0305515,FlyBase_Annotation_IDs:CG8933-PE; MD5=9ccc740604f50f454c6d95f0dff53e0d; length=376; release=r5.56; species=Dmel; [FlyBase]
  • type=protein; loc=X:join(15887542..15887806,15887998..15888316,15888380..15888638,15888718..15889005); ID=FBpp0305514; name=exd-PD; parent=FBgn0000611,FBtr0333322; dbxref=REFSEQ:NP_001259592,GB_protein:AGB95434,FlyBase:FBpp0305514,FlyBase_Annotation_IDs:CG8933-PD; MD5=9ccc740604f50f454c6d95f0dff53e0d; length=376; release=r5.56; species=Dmel; [FlyBase]
  • The gene extradenticle is referred to in FlyBase by the symbol Dmel\exd (CG8933, FBgn0000611). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15886520..15890040. It has the cytological map location 14A5. There is experimental evidence that it has the molecular function</span>: protein binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: oenocyte development; brain development. 59 alleles are reported. The phenotypes of these alleles are annotated with 54 unique terms, many of which group under: adult segment; organ system; thoracic segment; cephalopharyngeal skeleton; adult; antennal segment; appendage segment; embryonic nervous system; organ system subdivision; peripheral nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • The gene extradenticle is referred to in FlyBase by the symbol Dmel\exd (CG8933, FBgn0000611). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:15886520..15890040. It has the cytological map location 14A5. There is experimental evidence that it has the molecular function</span>: protein binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: oenocyte development; brain development. 59 alleles are reported. The phenotypes of these alleles are annotated with 54 unique terms, many of which group under: adult segment; organ system; thoracic segment; cephalopharyngeal skeleton; adult; antennal segment; appendage segment; embryonic nervous system; organ system subdivision; peripheral nervous system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 376 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS][TAS]
    cytoplasm [TAS]
    Biological Process: oenocyte development [IMP]
    salivary gland boundary specification [NAS][TAS]
    regulation of transcription, DNA-dependent [IEA]
    brain development [IMP]
    regulation of transcription [IEA]
    leg disc proximal/distal pattern formation [TAS]
    Molecular Function: DNA binding [IDA]
    transcription factor activity [IEA]
    protein binding [IPI]
    specific RNA polymerase II transcription factor activity [NAS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDPNRMLAH TGGMMAPQGY GLSGQDDGQN AGSENEVRKQ KDIGEILQQI MSISEQSLDE  60
   61 AQARKHTLNC HRMKPALFSV LCEIKEKTVL SIRNTQEEEP PDPQLMRLDN MLIAEGVAGP 120
  121 EKGGGGAAAA SAAAASQGGS LSIDGADNAI EHSDYRAKLA QIRQIYHQEL EKYEQACNEF 180
  181 TTHVMNLLRE QSRTRPITPK EIERMVQIIH KKFSSIQMQL KQSTCEAVMI LRSRFLDARR 240
  241 KRRNFSKQAS EILNEYFYSH LSNPYPSEEA KEELARKCGI TVSQVSNWFG NKRIRYKKNI 300
  301 GKAQEEANLY AAKKAAGASP YSMAGPPSGT TTPMMSPAPP QDSMGYPMGS GGYDQQQPYD 360
  361 NSMGGYDPNL HQDLSP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..165] Pfam 62.920819 No description for PF03792.4 was found. No confident structure predictions are available.
    2 View Details [166..240] FFAS03 0.985 No description for 2oszA was found.
    3 View Details [241..376] PSI-BLAST 18.522879 pbx1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.62096064323298 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle