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Protein Overview: mew-PB

General Information:
Name(s) found: mew-PB / FBpp0073563 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene multiple edematous wings is referred to in FlyBase by the symbol Dmel\mew (CG1771, FBgn0004456). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:13108442..13152523. It has the cytological map location 11E3-11E8. There is experimental evidence that it has the molecular function</span>: cell adhesion molecule binding; receptor activity. There is experimental evidence that it is involved in the biological process</span>: salivary gland boundary specification; axon guidance; axonal defasciculation; cell adhesion; imaginal disc-derived wing morphogenesis; maintenance of epithelial integrity, open tracheal system; muscle attachment; salivary gland morphogenesis. 38 alleles are reported. The phenotypes of these alleles are annotated with 18 unique terms, many of which group under: organ system; nervous system; peripheral nervous system; multi-cell-component structure; primordium; embryonic nervous system; endoderm derivative; extended germ band embryo; posterior midgut proper primordium; embryonic dorsal branch; embryonic/larval visceral branch; female germline cyst; midgut constriction; external compound sense organ; adult segment. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1146 amino acids

    Gene Ontology:
    Cellular Component: integrin complex [ISS][NAS]
    Biological Process: cell-cell adhesion [TAS]
    cell-matrix adhesion [ISS]
    midgut development [TAS]
    imaginal disc-derived wing morphogenesis [IEP][IMP][TAS]
    heterophilic cell-cell adhesion [TAS]
    salivary gland boundary specification [IMP]
    axon guidance [IMP]
    cell adhesion [IMP]
    ectodermal gut morphogenesis [TAS]
    salivary gland development [TAS]
    apposition of dorsal and ventral imaginal disc-derived wing surfaces [NAS]
    maintenance of epithelial integrity, open tracheal system [IGI]
    axonal defasciculation [IMP]
    tracheal outgrowth, open tracheal system [TAS]
    open tracheal system development [NAS]
    salivary gland morphogenesis [IGI]
    epithelial cell migration, open tracheal system [TAS]
    cell differentiation [TAS]
    cell migration [TAS]
    muscle attachment [IGI]
    Molecular Function: cell adhesion molecule binding [IMP][ISS]
    receptor activity [IMP][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLELPFTTIR PNCRLRQNLG ILIILQCVLT CYNFNLEQRL PIVKYGHPHS HFGYSVATHT  60
   61 IGEANGPNKT NCVLVGAPLD QNRQPNTTHS GALWRCPMTQ RFDDCEQVIT DGRRNFDSEI 120
  121 LSPPGNDEIK EDQWMGVTVR SNPLQANGSG GKVIVCAHRY MYIVRENRYG QGLCYLLTND 180
  181 LQFEEVHEPC KGRPVQRQHE DYGLCQAGTS AALLDDDTMV LGSPGPYTWR GSIWVTQVGG 240
  241 EYLQRDKTTY YSDHSDLNSP VDKYSYLGMS VTGGRFFGHM SYAAGAPRSE GHGQVVIFDK 300
  301 STDNPIPVHS ILDGEQFGSS FGYELATADI NGDHRPDLIV AAPLYFTKTE GGAVYVYQNI 360
  361 QDTLPMKYTL KLTGPLESRF GLALANIGDL NKDNCEDLAV GAPYEGNGVV YIYLGSSQGL 420
  421 NSKPAQKIQA SELGGTIPNG QPIRTFGISI SGNTDLDDNS YPDVVIGAFN SSAAVILLAR 480
  481 PIISIQTSVQ RKELHNMDPN TPGCLDDPAS NLTCFTFRAC CSIEPYDEKN KELRLAYSVE 540
  541 AETFDHLKKF SRVFFFDREN KRTNVLSRVV RVHTNGRTEC QAVTGYIKAN TRDIQTPVRF 600
  601 RLKYSLVEPP LADSALVRLN PILDQTQAHV DFEGTFQKDC GDDDLCESNL IIRVEPNITE 660
  661 SSGNEYTLIL DETELEVRIN VSNLADSAYE AQLFIAHQAG VSYVATKKPT NATCNSYNTT 720
  721 LVACSLGNPM LRDTTTFVTI RFQPKGLEPS EKIMLFHIFA NTTSKLVGPE RPERDLRVNV 780
  781 VRRAKLNFRG WAIPEQSFYS GSSVANSVAN TAATDIEGHG PMGMDDVGSQ VHHMFTIFNE 840
  841 GPSTAPKVQM VIHWPYSLYS DPQSGRPVQY LLYLEQVPTV EVSQGECHVA KEYVNPLNLA 900
  901 SGSRENPAYL SAPAQMRMFP SQSRHSFNKS LIHSQRSYYS SSHRDDHSDD TQSNRNRVRR 960
  961 SFLERVTRLE RLMYDPESSN AANGKKQDIV ELDCNKGATN CVRIECDILN MPALSEAQVV1020
 1021 VKARLWNSTL VSEYPRVERV RIFSTATAQI PESYGVEVMD HNNIEVETRA YPELRNQQRD1080
 1081 TSIPWLIIIL GIVGGLLLLA LVTYVLWKVG FFKRIRPTDP TLSGNLEKMN EEKPFLAPSK1140
 1141 NTHHVF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..1146] PSI-BLAST 1000.0 Thigh, calf-1 and calf-2 domains of integrin alpha; Integrin alpha N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • fibronectin binding
    		•  4.47872047963661 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  4.38909417354069 bayes_pls_golite062009
  • receptor activity
    		•  3.07436728891089 bayes_pls_golite062009
  • binding
    		•  3.02494522439205 bayes_pls_golite062009
  • protein binding
    		•  2.93314130654223 bayes_pls_golite062009
  • signal transducer activity
    		•  2.30570215634503 bayes_pls_golite062009
  • molecular transducer activity
    		•  2.30570215634503 bayes_pls_golite062009
  • extracellular matrix binding
    		•  2.29992000538847 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  1.89652634417708 bayes_pls_golite062009
  • integrin binding
    		•  1.46467851042106 bayes_pls_golite062009
  • laminin receptor activity
    		•  0.57752974249266 bayes_pls_golite062009
  • protein complex binding
    		•  0.317709418149211 bayes_pls_golite062009
  • receptor binding
    		•  0.272415627526009 bayes_pls_golite062009
  • laminin binding
    		•  0.0766626920324303 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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