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Protein Overview: hep-PA

General Information:
Name(s) found: hep-PA / FBpp0073578 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene hemipterous is referred to in FlyBase by the symbol Dmel\hep (CG4353, FBgn0010303). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12973240..12984466. It has the cytological map location 11D10. There is experimental evidence that it has the molecular function</span>: protein binding; protein kinase activity. There is experimental evidence for 21 unique biological process</span> terms, many of which group under: anatomical structure development; reproductive process in a multicellular organism; organ morphogenesis; cell projection organization; chemical homeostasis; ovarian follicle cell development; response to stress; organ development; cellular component movement; cell projection assembly. 43 alleles are reported. The phenotypes of these alleles are annotated with 32 unique terms, many of which group under: organ system; adult segment; external compound sense organ; peripheral nervous system; imaginal precursor; adult mesothoracic segment; thoracic segment; nervous system; larval thorax; embryonic/larval hemocoel; mouthpart; egg; embryonic segment; dorsal thoracic disc; primordium; cephalopharyngeal skeleton; late extended germ band embryo. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1178 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: dorsal closure [IMP][NAS][TAS]
    positive regulation of JUN kinase activity [IMP]
    dorsal closure, spreading of leading edge cells [IMP]
    determination of adult lifespan [IMP]
    JNK cascade [TAS]
    border follicle cell migration [IGI]
    protein amino acid phosphorylation [NAS][TAS]
    MAPKKK cascade [NAS]
    wound healing [IMP]
    response to heat [IMP]
    ovarian follicle cell development [IMP][TAS]
    basement membrane disassembly [IMP]
    triglyceride homeostasis [IMP]
    imaginal disc fusion, thorax closure [TAS]
    chorion-containing eggshell pattern formation [IMP]
    imaginal disc eversion [IMP]
    regulation of hemocyte differentiation [IMP]
    dorsal appendage formation [IMP]
    filopodium assembly [IMP]
    imaginal disc fusion [IMP]
    micropyle formation [IMP]
    regulation of transcription from RNA polymerase II promoter [NAS]
    axon extension [IMP]
    establishment of planar polarity [NAS]
    carbohydrate homeostasis [IMP]
    lamellipodium assembly [IMP]
    actin filament bundle assembly [IMP]
    Molecular Function: ATP binding [IEA]
    receptor signaling protein serine/threonine kinase activity [NAS]
    protein binding [IPI]
    MAP kinase kinase activity [ISS][NAS][TAS]
    protein kinase activity [IDA]
    protein serine/threonine kinase activity [IEA]
    JUN kinase kinase activity [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTIEFETIG SRLQSLEAKL QAQNESHDQI VLSGARGPVV SGSVPSARVP PLATSASAAT  60
   61 SATHAPSLGA GSVSGSGISI AQRPAPPVPH ATPFGSASAS SSSSSASAFA SAAPATGTFG 120
  121 GTYTPPTTRV SRATPTLPML SSGPGGGLNR TRPVILPLPT PPHPPVSETD MKLKIIMEQT 180
  181 GKLNINGRQY PTDINDLKHL GDLGNGTSGN VVKMMHLSSN TIIAVKQMRR TGNAEENKRI 240
  241 LMDLDVVLKS HDCKYIVKCL GCFVRDPDVW ICMELMSMCF DKLLKLSKKP VPEQILGKVT 300
  301 VATVNALSYL KDKHGVIHRD VKPSNILIDE RGNIKLCDFG ISGRLVDSKA NTRSAGCAAY 360
  361 MAPERIDPKK PKYDIRADVW SLGITLVELA TARSPYEGCN TDFEVLTKVL DSEPPCLPYG 420
  421 EGYNFSQQFR DFVIKCLTKN HQDRPKYPEL LAQPFIRIYE SAKVDVPNWF QSIKDNRLRA 480
  481 NGDPTLQRAT ATGSAIGSGA GSLAGSGSGS AGGAVKYGRA TTYAGQSPTN PQKTIKPTQI 540
  541 PSYQQQQSQF FMQSATQLPQ TTTTTPTATT NCFGGSGNGN GRGNGSGGSG NGSGSSSSAS 600
  601 PLSPPSAGIG DLNRLYRKSP FMQRKLSNGS HHPHYKYNDE SPKKESMFSS IGQSILRNLT 660
  661 TSPFSQKKHN STATTIPLPH NNQTLITDAA TAAAAAATAT TPPNIAATVL TTTPTTTPTW 720
  721 RLPTENSQAY DSCDSSSNAT TTTLNLGLSS PSPSLPRKQF PTESPTLQLT SQQQQQPQRL 780
  781 QPGNQSPIVL QRFYHQQNQL REKEAAERYQ QQRQQPPVGV TSTNPFHSNY VPPPPSTHST 840
  841 SSQSSTQSTC SQIAINPASI SPSSGSGTGN MAGLGIGSAP ASGLGAAGHF GAGGTGEQLQ 900
  901 YQPLPIAAEA TGTSPTLQSR SPEQQSDYGG NGNMVASKLS KLYARRQLLG QSSSSGASNS 960
  961 SLDGCSREQH DAGWFNTLAG AMKRQFATYV KTQLNSTATS PVASSMDRDQ EPVHPQPPAY1020
 1021 RSVVNNGSGG KSYYYRTLSA ASSSSNTSQS TSPTTEPLPG GGTSSFLRRY ASSGPGGSIS1080
 1081 TPPSPHILAG LDRRHRSPDP PPRYNRGQSP LLLRKNLLEL SGQPPGSPLL HRRYVSASPP1140
 1141 LPPPRRGSES VPGSPQHFRT RIHYTPEPQR RIYRTIDQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..171] PSI-BLAST 63.69897 Abl tyrosine kinase, SH3 domain; Abl tyrosine kinase; Abelsone tyrosine kinase (abl)
    2 View Details [172..459] PSI-BLAST 61.221849 No description for 2dylA was found.
    3 View Details [460..750] FFAS03 1.01 CRYSTAL STRUCTURE OF THE COLLAGEN-BINDING DOMAIN OF YERSINIA ADHESIN YadA
    4 View Details [751..936] deduced N/A No confident structure predictions are available.
    5 View Details [937..1178] MSA 2.314996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • cytoskeletal protein binding
    		•  4.41722924924158 bayes_pls_golite062009
  • actin binding
    		•  3.91045208670052 bayes_pls_golite062009
  • protein binding
    		•  3.13677730481089 bayes_pls_golite062009
  • binding
    		•  3.06905798270146 bayes_pls_golite062009
  • actin filament binding
    		•  2.72908433443928 bayes_pls_golite062009
  • structural constituent of muscle
    		•  1.87298566220664 bayes_pls_golite062009
  • structural molecule activity
    		•  0.989403012920596 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.371928447183203 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.89

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle