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Protein Overview: CG2574-PA

General Information:
Name(s) found: CG2574-PA / FBpp0073477 [FlyBase]
Description(s) found:
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  • gi|24641521|ref|NP_572796.1| CG2574 [Drosophila melanogaster] [NCBI NR]
  • gi|22832130|gb|AAF48159.2| CG2574 [Drosophila melanogaster] [NCBI NR]
  • gi|223968345|emb|CAR93903.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968343|emb|CAR93902.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968341|emb|CAR93901.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968339|emb|CAR93900.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968337|emb|CAR93899.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968333|emb|CAR93897.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|223968331|emb|CAR93896.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|21064215|gb|AAM29337.1| AT30415p [Drosophila melanogaster] [NCBI NR]
  • gi|194352832|emb|CAQ53208.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|194352830|emb|CAQ53207.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|194352824|emb|CAQ53204.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|194352822|emb|CAQ53203.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • gi|194352818|emb|CAQ53201.1| CG2574-PA [Drosophila melanogaster] [NCBI NR]
  • This gene is referred to in FlyBase by the symbol Dmel\CG2574 (CG2574, FBgn0030386). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:12302922..12303864. It has the cytological map location 11A9. Based on sequence similarity, it is predicted to have molecular function</span>: ubiquitin-protein ligase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: post-translational protein modification; regulation of protein metabolic process. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG2574-PA translation from_gene[CG2574 CG2574 FBgn0030386] seq_release:3 mol_weight=26662 cds_boundaries:(X:12,139,615..12,140,400[+]) aa_length:239 transcript_info:[CG2574-RA seq_release:3] gene_info:[gene symbol:CG2574 FBgn0030386 gene_boundaries:(X [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VYN3) CG2574 protein (EC 6.3.2.19) (AT30415p) (Ubiquitin-conjugating enzyme E2) (Ubiquitin-protein ligase) (Ubiquitin carrier protein) [DrosMelano7227.FASTAC.txt]
  • CG2574-PA [Drosophila melanogaster]gi|21064215|gb|AAM29337.1| AT30415p [Drosophila melanogaster]gi|24641521|ref|NP_572796.1| CG2574-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:join(12302988..12303473,12303543..12303776); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159; MD5=78 [fly-100309-contam.fasta]
  • CG2574-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • AT30415p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:join(12302988..12303473,12303543..12303776); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:join(12302988..12303473,12303543..12303776); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Ubiquitin carrier protein OS=Drosophila melanogaster GN=CG2574 PE=2 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:join(12302988..12303473,12303543..12303776); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159,FlyMine:FBpp0073477,modMine:FBpp0073477; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • AT30415p OS=Drosophila melanogaster GN=CG2574 PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=X:join(12408955..12409440,12409510..12409743); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159,FlyMine:FBpp0073477,modMine:FBpp0073477; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:join(12408955..12409440,12409510..12409743); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159,FlyMine:FBpp0073477,modMine:FBpp0073477; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0073477 type=protein; loc=X:join(12408955..12409440,12409510..12409743); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159,FlyMine:FBpp0073477,modMine:FBpp0073477; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:join(12408955..12409440,12409510..12409743); ID=FBpp0073477; name=CG2574-PA; parent=FBgn0030386,FBtr0073644; dbxref=FlyBase:FBpp0073477,FlyBase_Annotation_IDs:CG2574-PA,GB_protein:AAF48159.2,REFSEQ:NP_572796,GB_protein:AAF48159,UniProt/TrEMBL:Q9VYN3,FlyMine:FBpp0073477,modMine:FBpp0073477; MD5=78f0f85afe8569f48037ad802a356f66; length=239; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 239 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of protein metabolic process [IEA]
    post-translational protein modification [IEA]
    Molecular Function: ubiquitin-protein ligase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDQVNSQT EMETEARARA EVEVEVEPEV LSRASVASSV EETAPSTSHS ASGKSTEAPL  60
   61 TGCVVRIKSE LQDIRKNPPP NCTADLHHGD LLHWTAGVNG PVGSVYEGGH FRLDIRFPAS 120
  121 YPFRAPRIRF TTRIYHCNVD SRGAICLDVL GERWSPVMNV AKVLLSIYVL MSECNPDDPL 180
  181 VMCIADQYKT NRREHDKIAR HWTKLFAMTK AQDKNREKDA DQGNEQNQEE NPMPGQQGN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..239] PSI-BLAST 52.69897 The 1.1A crystallographic structure of ubiquitin-conjugating enzyme (ubc-2) from Caenorhabditis elegans: functional and evolutionary significance

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ubiquitin-protein ligase activity
    		•  11.3486134076304 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  11.2964721480824 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  10.2401422444624 bayes_pls_golite062009
  • ligase activity, forming carbon-nitrogen bonds
    		•  8.93602533934698 bayes_pls_golite062009
  • ligase activity
    		•  5.17219147802758 bayes_pls_golite062009
  • SUMO ligase activity
    		•  3.88357560284404 bayes_pls_golite062009
  • ISG15 ligase activity
    		•  3.37361650623694 bayes_pls_golite062009
  • NEDD8 ligase activity
    		•  3.30521803258995 bayes_pls_golite062009
  • HLH domain binding
    		•  2.41376652679018 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.21355731489173 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.13970605403492 bayes_pls_golite062009
  • DNA binding
    		•  1.95596447916631 bayes_pls_golite062009
  • protein binding
    		•  1.77678273247394 bayes_pls_golite062009
  • binding
    		•  1.75350658654805 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.5236035191291 bayes_pls_golite062009
  • transcription activator activity
    		•  1.19240180311941 bayes_pls_golite062009
  • catalytic activity
    		•  0.891402822028799 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.58835335751383 bayes_pls_golite062009
  • kinase activity
    		•  0.519703305315987 bayes_pls_golite062009
  • protein kinase activity
    		•  0.443948654247666 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.373779304908933 bayes_pls_golite062009
  • small protein activating enzyme activity
    		•  0.36227294335656 bayes_pls_golite062009
  • protein serine/threonine kinase activity
    		•  0.182854082413338 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.122859425935324 bayes_pls_golite062009
  • transferase activity
    		•  0.0984525836903841 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0104967529560147 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle