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Protein Overview: FBpp0309612, Upf1-PA

General Information:
Name(s) found: FBpp0309612 [FlyBase]
Upf1-PA / FBpp0073433 [FlyBase]
Description(s) found:
Found 28 descriptions.
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  • type=protein; loc=X:complement(11795271..11795312,11795382..11798714,11798777..11798944); ID=FBpp0309612; name=Upf1-PB; parent=FBgn0030354,FBtr0342744; dbxref=FlyBase:FBpp0309612,FlyBase_Annotation_IDs:CG1559-PB; MD5=0d1c3b90f9acbb265f6b829c72b870e6; length=1180; release=r5.56; species=Dmel; [FlyBase]
  • The gene Upf1 is referred to in FlyBase by the symbol Dmel\Upf1 (CG1559, FBgn0030354). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11794470..11799373. It has the cytological map location 10F4. Based on sequence similarity, it is predicted to have molecular function</span>: helicase activity. There is experimental evidence that it is involved in the biological process</span>: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1180 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA][NAS]
    Biological Process: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IMP][ISS][NAS]
    [NOT]gene silencing by miRNA [IMP]
    [NOT]RNA interference [IMP]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    zinc ion binding [IEA]
    helicase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVDTYAPSS ALSFLDMDDN ELLPGADTQP TQYDYRDFTM PSTSQSQTQN DQLEIAQRCS  60
   61 AGDSHPRLAS ITNDLADLQF EEEDDEPGSS YVKELPPHAC KYCGIHDPAT VVMCNNCRKW 120
  121 FCNGRGSTSG SHIINHLVRA KHREVTLHGE GPLGETILEC YSCGVRNVFV LGFIPAKADS 180
  181 VVVLLCRQPC AAQNSLKDMN WDQEQWKPLI ADRCFLAWLV KQPSEQGQLR ARQISAAQIN 240
  241 KLEELWKENI EATFQDLEKP GIDSEPAHVL LRYEDGYQYE KTFGPLVRLE AEYDQKLKES 300
  301 ATQENIEVRW DVGLNKKTIA YFTLAKTDSD MKLMHGDELR LHYVGELYNP WSEIGHVIKV 360
  361 PDNFGDDVGL ELKSSTNAPV KCTSNFTVDF IWKCTSFDRM TRALCKFAID RNSVSNFIYS 420
  421 RLLGHGRADS NDEVLFRGPQ PKLFSAPHLP DLNRSQVYAV KHALQRPLSL IQGPPGTGKT 480
  481 VTSATIVYQL VKLHGGTVLV CAPSNTAVDQ LTEKIHRTNL KVVRVCAKSR EAIDSPVSFL 540
  541 ALHNQIRNME TNSELKKLQQ LKDETGELSS ADEKRYRNLK RAAENQLLEA ADVICCTCVG 600
  601 AGDGRLSRVK FTSILIDESM QSTEPECMVP VVLGAKQLIL VGDHCQLGPV VMCKKAARAG 660
  661 LSQSLFERLV VLGIRPFRLE VQYRMHPELS QFPSNFFYEG SLQNGVCAED RRLKLDFPWP 720
  721 QPERPMFFLV TQGQEEIAGS GTSFLNRTEA ANVEKITTRF LKAGIKPEQI GIITPYEGQR 780
  781 AYLVQYMQYQ GSLHSRLYQE IEIASVDAFQ GREKDIIIMS CVRSNERQGI GFLNDPRRLN 840
  841 VALTRAKFGI IIVGNPKVLA KQQLWNHLLN FYKDRKVLVE GSLNNLKESL IHFQKPKKLV 900
  901 NSMNIGAHFM STIIADAKEV MVPGSIYDRS GGYGQGRQMV GQSMNGGQYG GSGGGPYGNS 960
  961 PLGYGTPSSN SMVGFGLGNG GNGAAGGNNN FGGAGPSWAA AHLHHDSIGY ISNEHGAAAL1020
 1021 GNMPVPVGMF MNMSNIPPRF YNQHQQAIMA VKQNRAIQQQ TGNFSPGNSG PGVTGVGVGR1080
 1081 SATPGGNKKT NKLGKSRVTG GGTGGAPLTQ GSSVCNAAPY SQHPMPLSLQ MTQPSGFALS1140
 1141 QQPELSQDFG QISQMDGLLS QDVAFNASGE RSLNQFSQPY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..89] deduced N/A No confident structure predictions are available.
    2 View Details [90..258] PSI-BLAST 75.30103 No description for 2iykA was found.
    3 View Details [259..907] PSI-BLAST 1000.0 No description for 2gjkA was found.
    4 View Details [908..1180] PSI-BLAST 36.30103 No description for 1y0fB was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle