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Protein Overview: Dlic-PD, Dlic-PA

General Information:
Name(s) found: Dlic-PD / FBpp0073299 [FlyBase]
Dlic-PA / FBpp0073297 [FlyBase]
Description(s) found:
Found 44 descriptions.
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  • The gene Dynein light intermediate chain is referred to in FlyBase by the symbol Dmel\Dlic (CG1938, FBgn0030276). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11048434..11057245. It has the cytological map location 10A8. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled; motor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of dendrite morphogenesis; dendrite morphogenesis; mitotic spindle organization; oogenesis; microtubule cytoskeleton organization; axon cargo transport. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Dynein light intermediate chain is referred to in FlyBase by the symbol Dmel\Dlic (CG1938, FBgn0030276). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:11048434..11057245. It has the cytological map location 10A8. Based on sequence similarity, it is predicted to have molecular function</span>: ATPase activity, coupled; motor activity. There is experimental evidence that it is involved in the biological process</span>: regulation of dendrite morphogenesis; dendrite morphogenesis; mitotic spindle organization; oogenesis; microtubule cytoskeleton organization; axon cargo transport. 10 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 493 amino acids

    Gene Ontology:
    Cellular Component: cytoplasmic dynein complex [IDA][ISS]
    dynein complex [ISS]
    microtubule associated complex [ISS]
    Biological Process: axon cargo transport [IMP]
    oogenesis [IMP]
    mitotic spindle organization [IMP]
    microtubule cytoskeleton organization [IMP]
    microtubule-based movement [ISS]
    regulation of dendrite morphogenesis [IMP]
    dendrite morphogenesis [IDA][IMP]
    Molecular Function: motor activity [ISS]
    ATPase activity, coupled [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAMNSGTQTN ALTSSFTMKK KDAAAEKENL WSAILNEVQT QGSTKLPSNK SVLVLGDNAT  60
   61 GKTTLIAKLQ GVEDPKKGSG LEYAYIDVKD EYRDDMTRLG VWVLDGDPGH TNLLHYALNE 120
  121 TNYAHTLVIL TVSMTQPWGW LEQLNHWIKV LGQHIDSLQL DAKEKEAARQ RLTTTWQSYC 180
  181 EVGDDLDPGS PVKRTMRNNS IDEDDLLPLT EDALITNLGL DIVVVVTKTD YMTTLEKEYE 240
  241 YRDEHFDFIQ QWIRNFCLRH GTSLFYTSVK EDKNCDVLYK YLTHRIYGLP FRTPALVVEK 300
  301 DAVLIPAGWD SLKKISILYE NMHGVKAENP YTDIIKSPPT RKAVSNREAE VQTEDEQAFL 360
  361 ARQQEILKQG DQVRGESPLR SQGVGSNKSG PRTPGTTGQS SPKKIDPKLT PATPGAEGVL 420
  421 ANFFNSLLHK KSGSPGTGGP GGAGNPAGPG RTANGTDAVM TPEKLAVRTD AAAELDRLSR 480
  481 SVKKEIDMSQ SEC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..240] PSI-BLAST 42.0 Structure of doubly prenylated Ypt1:GDI complex
    2 View Details [241..384] MSA 1.054994 View MSA. No confident structure predictions are available.
    3 View Details [385..493] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • microtubule motor activity
    		•  7.68336791348661 bayes_pls_golite062009
  • motor activity
    		•  4.04927796049806 bayes_pls_golite062009
  • plus-end-directed microtubule motor activity
    		•  3.89478272344579 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.9316157348091 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.85508132376901 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.83578652703908 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.83259287122192 bayes_pls_golite062009
  • tubulin binding
    		•  2.67743463093593 bayes_pls_golite062009
  • microtubule binding
    		•  2.59155206524122 bayes_pls_golite062009
  • transporter activity
    		•  2.54024930442614 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  2.4101693596493 bayes_pls_golite062009
  • ATPase activity
    		•  2.3671333448422 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  2.35987232569028 bayes_pls_golite062009
  • binding
    		•  2.21604035604783 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  2.15516086601295 bayes_pls_golite062009
  • actin binding
    		•  1.75397031486306 bayes_pls_golite062009
  • hydrolase activity
    		•  1.55579437761895 bayes_pls_golite062009
  • microfilament motor activity
    		•  1.28029120876672 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.26618119830599 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.912853112793192 bayes_pls_golite062009
  • nucleotide binding
    		•  0.905342574142397 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.904115761720541 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.904053997411779 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.877711904204486 bayes_pls_golite062009
  • actin filament binding
    		•  0.728264616959762 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.403546959736573 bayes_pls_golite062009
  • ATP binding
    		•  0.38929752840764 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.364108656344062 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.356069365520539 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.328995639437459 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.264741960233164 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.252628307425696 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.191104435852081 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.190037546554641 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.189653398557061 bayes_pls_golite062009
  • protein binding
    		•  0.170837278876362 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.115161972169563 bayes_pls_golite062009
  • GTPase activity
    		•  0.105546189348878 bayes_pls_golite062009
  • minus-end-directed microtubule motor activity
    		•  0.068779631341469 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.0111338193708552 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle