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Protein Overview: iav-PA

General Information:
Name(s) found: iav-PA / FBpp0070930 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene inactive is referred to in FlyBase by the symbol Dmel\iav (CG4536, FBgn0086693). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6708151..6712189. It has the cytological map location 6D3. Based on sequence similarity, it is predicted to have molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: sensory perception of sound; response to heat; flight behavior. 17 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1123 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: sensory perception of sound [IMP]
    response to heat [IMP]
    ion transport [IEA]
    transmembrane transport [IEA]
    behavioral response to cocaine [NAS]
    flight behavior [IMP]
    sensory perception of smell [ISS]
    calcium ion transport [ISS]
    Molecular Function: ion channel activity [NAS]
    calcium channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFLLKKCLR KKAPEMKPGA ILDAVISQSS ATACKCLLYK LADYKRGGDL IDAINSGGLI  60
   61 AVEQLIREQF GVFMYNDGKG QVINRAEFLR WKYRDHTEVT IPIEASLSIH DPLGKWEDHK 120
  121 ACWQMQYRGA LGESLLHVLI ICDSKVHTKL ARVLLRVFPN LALDVMEGEE YLGASALHLS 180
  181 IAYSNNELVA DLIEAGADIH QRAIGSFFLP RDQQRANPAK STDYEGLAYM GEYPLAWAAC 240
  241 CANESVYNLL VDCGSDPDAQ DSFGNMILHM VVVCDKLDMF GYALRHPKTP AKNGIVNQTG 300
  301 LTPLTLACKL GRAEVFREML ELSAREFWRY SNITCSGYPL NALDTLLPDG RTNWNSALFI 360
  361 ILNGTKPEHL DMLDGGIIQR LLEEKWKTFA QNQFLKRLLI LSTHLLCLSV SVYLRPAHDG 420
  421 EAEDEDSEGS DASAAALLDI QSDEGDSGGG DYNAQTVARY CAEFATLVGV LSYVIFQQGD 480
  481 EIKNQGLSAF LKQLSHAPAK AIFLFSNLLI LACIPFRLIG DTDTEEAILI FAVPGSWFLL 540
  541 MFFAGAIRLT GPFVTMIYSM ITGDMFTFGI IYCIVLCGFS QAFYFLYKGH PQVQSTMFNT 600
  601 YTSTWMALFQ TTLGDYNYPD LNQTTYPNLS KTVFVIFMIF VPILLLNMLI AMMGNTYVTV 660
  661 IEQSEKEWMK QWAKIVVTLE RAVPQADAKG YLEAYSIPLG PSDDSGFEVR GVMVIKSKSK 720
  721 TRAKQRKGAV SNWKRVGRVT LTALKKRGMT GEEMRRLMWG RASISSPVKV TKQKLKDPYN 780
  781 LHTDSDFTNA MDMLTFASNP ASSNGVTLRS VTAPPPAPPA PDPFRELIMM SDQRPETHDP 840
  841 HYFAGLQQLA NKAFDLVEQT MKTQPQAPVA KKVDPLPVAS VAKASPAAPA TQATATAAAA 900
  901 SDLMAMPLPI SNLSNLFQDP KDIVDPKKLE EFMAMLAEVE TEESDSGGPI LGKLSLAKRT 960
  961 HNALSKAEIR RDQQGFEGHS HGQFQPMSSV WAPPGLDVDT GFHFDEAVAE EVLTIEQEAE1020
 1021 VETEDGNGGQ DSEDIPTAEE VHATMKQFHL RKCQPAQDEA ARRAKSARVR RRNKVSPEQS1080
 1081 DDPDERSQRG RSAYTRRTQS PPDPLEPWST RELQDINKIL ARK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..337] PSI-BLAST 77.30103 Ankyrin-R
    2 View Details [338..449] PSI-BLAST 8.154902 Swi6 ankyrin-repeat fragment
    3 View Details [450..806] FFAS03 1.16 Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
    4 View Details [807..1123] FFAS03 1.4 THE BLUETONGUE VIRUS (BTV) CORE BINDS DSRNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ion transmembrane transporter activity
    		•  2.61798755733032 bayes_pls_golite062009
  • binding
    		•  2.54053419376679 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  2.38927727467074 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.34936907992218 bayes_pls_golite062009
  • metal ion transmembrane transporter activity
    		•  2.1976632766775 bayes_pls_golite062009
  • calcium channel activity
    		•  2.0989077584416 bayes_pls_golite062009
  • protein binding
    		•  1.54890102798695 bayes_pls_golite062009
  • channel activity
    		•  1.40958988162637 bayes_pls_golite062009
  • passive transmembrane transporter activity
    		•  1.40958988162637 bayes_pls_golite062009
  • ion channel activity
    		•  1.34720887980415 bayes_pls_golite062009
  • cation channel activity
    		•  1.34152568706616 bayes_pls_golite062009
  • substrate-specific channel activity
    		•  1.25809788464511 bayes_pls_golite062009
  • transporter activity
    		•  1.19000052859754 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.02570255606772 bayes_pls_golite062009
  • gated channel activity
    		•  0.69203780961853 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.581121752453591 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.57950150183949 bayes_pls_golite062009
  • ankyrin binding
    		•  0.550286963220929 bayes_pls_golite062009
  • mechanically-gated ion channel activity
    		•  0.183140618513339 bayes_pls_golite062009
  • mechanically gated channel activity
    		•  0.183140618513339 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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