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Protein Overview: dx-PA

General Information:
Name(s) found: dx-PA / FBpp0070876 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene deltex is referred to in FlyBase by the symbol Dmel\dx (CG3929, FBgn0000524). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6428043..6432615. It has the cytological map location 6B1-6B2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; Notch signaling pathway; positive regulation of Notch signaling pathway; Wnt receptor signaling pathway. 33 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: peripheral nervous system; nervous system; adult segment; adult mesothoracic segment; organ system; external compound sense organ; eo support cell; acrostichal bristle; integumentary plate; compound cell cluster organ. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 738 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDA][NAS]
    Biological Process: Notch signaling pathway [IGI][IPI][TAS]
    regulation of Notch signaling pathway [NAS]
    Wnt receptor signaling pathway [IMP]
    negative regulation of Notch signaling pathway [IDA]
    positive regulation of Notch signaling pathway [IDA][TAS]
    Molecular Function: zinc ion binding [IEA]
    protein binding [IPI][ISS]
    Notch binding [TAS]
    SH3 domain binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASSAGSAAS GSVVPGGGGS AASSCATMAL STAGSGGPPV NHAHAVCVWE FESRGKWLPY  60
   61 SPAVSQHLER AHAKKLTRVM LSDADPSLEQ YYVNVRTMTQ ESEAETAGSG LLTIGVRRMF 120
  121 YAPSSPAGKG TKWEWSGGSA DSNNDWRPYN MHVQCIIEDA WARGEQTLDL CNTHIGLPYT 180
  181 INFCNLTQLR QPSGPMRSIR RTQQAPYPLV KLTPQQANQL KSNSASVSSQ YNTLPKLGDT 240
  241 KSLHRVPMTR QQHPLPTSHQ VQQQQHQHQH QQQQQQQHHH QHQQQQHQQQ QQHQMQHHQI 300
  301 HHQTAPRKPP KKHSEISTTN LRQILNNLNI FSSSTKHQSN MSTAASASSS SSSASLHHAN 360
  361 HLSHAHFSHA KNMLTASMNS HHSRCSEGSL QSQRSSRMGS HRSRSRTRTS DTDTNSVKSH 420
  421 RRRPSVDTVS TYLSHESKES LRSRNFAISV NDLLDCSLGS DEVFVPSLPP SSLGERAPVP 480
  481 PPLPLHPRQQ QQQQQQQQQL QMQQQQQAQQ QQQQSIAGSI VGVDPASDMI SRFVKVVEPP 540
  541 LWPNAQPCPM CMEELVHSAQ NPAISLSRCQ HLMHLQCLNG MIIAQQNEMN KNLFIECPVC 600
  601 GIVYGEKVGN QPIGSMSWSI ISKNLPGHEG QNTIQIVYDI ASGLQTEEHP HPGRAFFAVG 660
  661 FPRICYLPDC PLGRKVLRFL KIAFDRRLLF SIGRSVTTGR EDVVIWNSVD HKTQFNMFPD 720
  721 PTYLQRTMQQ LVHLGVTD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..262] PSI-BLAST 52.39794 Crystal Structure of the tandem WWE domain of Drosophila Deltex
    2 View Details [263..397] deduced N/A No confident structure predictions are available.
    3 View Details [398..524] MSA 6.312996 View MSA. No confident structure predictions are available.
    4 View Details [525..637] PSI-BLAST 14.69897 Solution Structure of the Ring-H2 Finger Domain of Mouse Deltex Protein 2
    5 View Details [638..738] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • Notch binding
    		•  2.92660801070981 bayes_pls_golite062009
  • protein binding
    		•  1.92218838849639 bayes_pls_golite062009
  • binding
    		•  1.6234987165625 bayes_pls_golite062009
  • receptor binding
    		•  0.681627758990235 bayes_pls_golite062009
  • protein domain specific binding
    		•  0.169218013172214 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • protein binding
    		•  2.64803540957326 bayes_pls_golite062009
  • binding
    		•  2.14721962003828 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.587037280321105 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.457219654632707 bayes_pls_golite062009
  • transcription factor binding
    		•  0.0370371235994398 bayes_pls_golite062009
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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