Protein Overview: Spx-PA

General Information:
Name(s) found:	Spx-PA / FBpp0070859 [FlyBase]
Description(s) found: Found 22 descriptions. SHOW ALL	The gene Spliceosomal protein on the X is referred to in FlyBase by the symbol Dmel\Spx (CG3780, FBgn0015818). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:6149866..6151452. It has the cytological map location 5E3. Based on sequence similarity, it is predicted to have molecular function</span>: mRNA binding. There is experimental evidence that it is involved in the biological process</span>: mitotic spindle organization. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	347 amino acids
Gene Ontology:
Cellular Component:	precatalytic spliceosome [IDA] spliceosomal complex [ISS][NAS] U2 snRNP [ISS]
Biological Process:	mitotic spindle organization [IMP] nuclear mRNA splicing, via spliceosome [IC][ISS]
Molecular Function:	nucleotide binding [IEA] nucleic acid binding [IEA] mRNA binding [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAAGPIAERN QDATIYAGGL DDKVSETLLW ELFVQAGPVV NVHMPKDRVT QMHQGYGFVE  60
   61 FLSEEDADYG IKIMNMIKLY GKPIRVNKAS AHQKNLDVGA NIFIGNLDVE VDEKLLYDTF 120
  121 SAFGVILQTP KIMRDPETGK SKSFAFINFA SFEASDAAMD AMNGQYLCNR PISVSYAFKK 180
  181 DHKGERHGSA AERLLAAQNP STHADRPHQL FADAPVQTMM PQMPGQIPAQ MPGQMMPPPM 240
  241 MAPPPPVVPV SNNNMGMLAP PPPVPQPAPF PATIPPPPLP PMTGGQPPLP PAMGIPPPPR 300
  301 MMQPNAWAPP GMPAPPPRPP PTNWRPPPVP FPPTPYARPY QPDGYQY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..91]	PSI-BLAST	21.69897	Solution structure of RRM domain in splicing factor 3B
2	View Details	[92..225]	FFAS03	5.0	CBP20, 20KDa nuclear cap-binding protein
3	View Details	[226..347]	PSI-BLAST	4.0	Sec24

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
RNA binding	6.73097473547076	bayes_pls_golite062009
	6.62953239642182	bayes_pls_golite062009
mRNA binding	5.29759606920196	bayes_pls_golite062009
nucleic acid binding	4.50398990564944	bayes_pls_golite062009
binding	4.16717332578111	bayes_pls_golite062009
snRNA binding	4.06596327298973	bayes_pls_golite062009
poly-pyrimidine tract binding	3.11990160533699	bayes_pls_golite062009
U1 snRNA binding	3.02511982045347	bayes_pls_golite062009
single-stranded RNA binding	2.93798024346416	bayes_pls_golite062009
transcription regulator activity	2.18211199677674	bayes_pls_golite062009
DNA binding	1.73925834998328	bayes_pls_golite062009
structural molecule activity	1.56454315220334	bayes_pls_golite062009
U2 snRNA binding	1.34078165372485	bayes_pls_golite062009
protein binding	1.10597581610211	bayes_pls_golite062009
transcription factor activity	0.873765500321315	bayes_pls_golite062009
mRNA 3'-UTR binding	0.591700155096213	bayes_pls_golite062009
sequence-specific DNA binding	0.294937517750882	bayes_pls_golite062009

2

Term	Confidence	Notes
	6.40066880991253	bayes_pls_golite062009
RNA binding	6.32219487559982	bayes_pls_golite062009
mRNA binding	4.87640532914983	bayes_pls_golite062009
nucleic acid binding	4.23531598582972	bayes_pls_golite062009
binding	4.00350364031155	bayes_pls_golite062009
snRNA binding	3.77997752511163	bayes_pls_golite062009
U1 snRNA binding	2.73908382552928	bayes_pls_golite062009
poly-pyrimidine tract binding	2.7133834347239	bayes_pls_golite062009
single-stranded RNA binding	2.55628738360472	bayes_pls_golite062009
transcription regulator activity	2.2045206027152	bayes_pls_golite062009
DNA binding	1.74537942253096	bayes_pls_golite062009
structural molecule activity	1.57342338925793	bayes_pls_golite062009
U2 snRNA binding	1.09350203162237	bayes_pls_golite062009
protein binding	1.04187682253755	bayes_pls_golite062009
transcription factor activity	0.894914712180715	bayes_pls_golite062009
sequence-specific DNA binding	0.238420044364247	bayes_pls_golite062009
mRNA 3'-UTR binding	0.229644510503376	bayes_pls_golite062009

3

No functions predicted.

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

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