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Protein Overview: CG7024-PA

General Information:
Name(s) found: CG7024-PA / FBpp0070680 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG7024 (CG7024, FBgn0029722). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:4599342..4601537. It has the cytological map location 4C14. Based on sequence similarity, it is predicted to have molecular function</span>: pyruvate dehydrogenase (acetyl-transferring) activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction; glycolysis. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 479 amino acids

    Gene Ontology:
    Cellular Component: pyruvate dehydrogenase complex [ISS]
    intracellular membrane-bounded organelle [IEA]
    Biological Process: glycolysis [IEA]
    oxidation reduction [IEA]
    Molecular Function: pyruvate dehydrogenase (acetyl-transferring) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKFSCVRVA MRCSGAHSIL ERNMLCRIIG RHKCSCLTLE NTFKCYDLEN GPTMDVELSR  60
   61 EDALTMYTQM LELRRFETVA GNYYKERKIR GFCHLYNGQE AVAVGMKQRL RSCDSVITAY 120
  121 RCHAWTYLMG VSLYEIMAEL FGVRTGCSRG KGGSMHMYSD KFYGGNGIVG AQVPLGAGIG 180
  181 LAHSYRKDNG VSVVLYGDGA ANQGQIFESF NMAKLWCLPC IFVCENNHYG MGTHVKRASA 240
  241 MTEFYMRGQY IPGLWVDGNQ VLAVRSATQF AVDHALKHGP IVLEMSTYRY VGHSMSDPGT 300
  301 SYRSREEVQS TREKRDPITS FRSQIIALCL ADEEELKALD DKTRKQVDSI CKKATTDREV 360
  361 ELDELHTDIY AKNVDGKIRG VSGFHLEHIK LAEVCFGKPK KTPASEINDV PVGAEIDVAK 420
  421 AKERKAKQDA KKAKEAKEPK GGDKKGADAK QPKGEGDDGD KKPKPAAQPP TKAPPAPKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..397] PSI-BLAST 90.154902 E1-beta subunit of pyruvate dehydrogenase (PP module)
    2 View Details [398..479] MSA 2.317993 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate dehydrogenase activity
    		•  11.3856674722026 bayes_pls_golite062009
  • pyruvate dehydrogenase (acetyl-transferring) activity
    		•  11.0549577473177 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
    		•  10.8180381281695 bayes_pls_golite062009
  • 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
    		•  7.00951713446616 bayes_pls_golite062009
  • alpha-ketoacid dehydrogenase activity
    		•  6.25236550086321 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  4.89064211833637 bayes_pls_golite062009
  • acetolactate synthase activity
    		•  4.51986503762195 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  3.8269109174531 bayes_pls_golite062009
  • 2-oxoisovalerate dehydrogenase (acylating) activity
    		•  3.00128844859152 bayes_pls_golite062009
  • cyclin-dependent protein kinase 5 activator regulator activity
    		•  3.00128844859152 bayes_pls_golite062009
  • catalytic activity
    		•  2.25537597692103 bayes_pls_golite062009
  • oxidoreductase activity
    		•  1.85833680148029 bayes_pls_golite062009
  • transketolase activity
    		•  1.53492491341322 bayes_pls_golite062009
  • protein binding
    		•  0.992849906276347 bayes_pls_golite062009
  • binding
    		•  0.750068469698571 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  0.667418924427388 bayes_pls_golite062009
  • pyruvate decarboxylase activity
    		•  0.198062360371269 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.66

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle