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View Structure Prediction Details

Protein: CG7024-PA
Organism: Drosophila melanogaster
Length: 479 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CG7024-PA.

Description E-value Query
Range		 Subject
Range
ODPA_MOUSE - Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial OS=Mus musculus GN=Pd...
 361.0 [0..2] [383..1]

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Predicted Domain #1
Region A:
Residues: [1-397] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMKFSCVRVA MRCSGAHSIL ERNMLCRIIG RHKCSCLTLE NTFKCYDLEN GPTMDVELSR  60
   61 EDALTMYTQM LELRRFETVA GNYYKERKIR GFCHLYNGQE AVAVGMKQRL RSCDSVITAY 120
  121 RCHAWTYLMG VSLYEIMAEL FGVRTGCSRG KGGSMHMYSD KFYGGNGIVG AQVPLGAGIG 180
  181 LAHSYRKDNG VSVVLYGDGA ANQGQIFESF NMAKLWCLPC IFVCENNHYG MGTHVKRASA 240
  241 MTEFYMRGQY IPGLWVDGNQ VLAVRSATQF AVDHALKHGP IVLEMSTYRY VGHSMSDPGT 300
  301 SYRSREEVQS TREKRDPITS FRSQIIALCL ADEEELKALD DKTRKQVDSI CKKATTDREV 360
  361 ELDELHTDIY AKNVDGKIRG VSGFHLEHIK LAEVCFG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 90.154902
Match: 1ni4A
Description: E1-beta subunit of pyruvate dehydrogenase (PP module)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
pyruvate dehydrogenase activity 11.3856674722026 bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity 11.0549577473177 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor 10.8180381281695 bayes_pls_golite062009
3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity 7.00951713446616 bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity 6.25236550086321 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 4.89064211833637 bayes_pls_golite062009
acetolactate synthase activity 4.51986503762195 bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups 3.8269109174531 bayes_pls_golite062009
2-oxoisovalerate dehydrogenase (acylating) activity 3.00128844859152 bayes_pls_golite062009
cyclin-dependent protein kinase 5 activator regulator activity 3.00128844859152 bayes_pls_golite062009
catalytic activity 2.25537597692103 bayes_pls_golite062009
oxidoreductase activity 1.85833680148029 bayes_pls_golite062009
transketolase activity 1.53492491341322 bayes_pls_golite062009
protein binding 0.992849906276347 bayes_pls_golite062009
binding 0.750068469698571 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 0.667418924427388 bayes_pls_golite062009
pyruvate decarboxylase activity 0.198062360371269 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [398-479] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KPKKTPASEI NDVPVGAEID VAKAKERKAK QDAKKAKEAK EPKGGDKKGA DAKQPKGEGD  60
   61 DGDKKPKPAA QPPTKAPPAP KK

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle