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Protein Overview: mus81-PA

General Information:
Name(s) found: mus81-PA / FBpp0070165 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene mus81 is referred to in FlyBase by the symbol Dmel\mus81 (CG3026, FBgn0040347). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:835090..837262. It has the cytological map location 1D2. It is reported to have molecular function</span>: crossover junction endodeoxyribonuclease activity. It is reported to be involved in the biological process</span>: reciprocal meiotic recombination. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 426 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: reciprocal meiotic recombination [NAS]
    DNA metabolic process [IEA]
    Molecular Function: DNA binding [IEA]
    protein binding [IEA]
    nuclease activity [IEA]
    crossover junction endodeoxyribonuclease activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 METRLEVLLR EPNPLFTRWL ERWLREAERR EQKSQFSLRQ ALESLKSYPL PLASGRDCSI  60
   61 LRGFGGTLCQ LIDEELRHHR GLQLLPQEAV VQERYEQQVQ AVVRKVQEKQ LEHQKRQNKC 120
  121 DRPRKLTKKD LAELAALEER ERVVRMKPGQ FQLLLLVDTQ ETSGKNKRVL DQTRSYLESL 180
  181 GARHEVRRLT IGDFLWVAQD QEGNELVLPY IVERKRMDDL ASSIRDGRFH EQKHRLQHCG 240
  241 LQHIIYLVED YGDNEQLGLP LDSLQQALTN AKVQTGVRVV RTANHYRSMS YLAGMSRTLG 300
  301 QIFAGKKLHS VDRGAIDQST CLLTHSDLGL LKFRALYEDS AKNAQLTVRE VFVQQLLQLH 360
  361 SLSLERAMAI VERYPTPRWL LDAYAECADQ KQARLLLASI PCGPLERPLG DKISQCLHEF 420
  421 YSTHFR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..137] PSI-BLAST 7.0 Crystal structure of Pyrococcus furiosus Hef helicase domain
    2 View Details [138..426] PSI-BLAST 33.69897 XPF from Aeropyrum pernix, complex with DNA

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • four-way junction helicase activity
    		•  2.93834618926168 bayes_pls_golite062009
  • deoxyribonuclease activity
    		•  2.38833494621917 bayes_pls_golite062009
  • endodeoxyribonuclease activity
    		•  2.33372429725567 bayes_pls_golite062009
  • DNA helicase activity
    		•  1.83146987493465 bayes_pls_golite062009
  • single-stranded DNA specific endodeoxyribonuclease activity
    		•  1.42238952652053 bayes_pls_golite062009
  • catalytic activity
    		•  1.18688703641003 bayes_pls_golite062009
  • helicase activity
    		•  1.14079869095094 bayes_pls_golite062009
  • nuclease activity
    		•  0.90252859343276 bayes_pls_golite062009
  • endonuclease activity
    		•  0.87027578644028 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.70849567386272 bayes_pls_golite062009
  • hydrolase activity
    		•  0.7029472543514 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.67049159133539 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.66774107373566 bayes_pls_golite062009
  • excinuclease ABC activity
    		•  0.66562067290586 bayes_pls_golite062009
  • protein binding
    		•  0.330444531124157 bayes_pls_golite062009
  • binding
    		•  0.240779272133325 bayes_pls_golite062009
  • DNA binding
    		•  0.0778795682272901 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.0669727336969201 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.05756449780621 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.0572628370858399 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.0554315973046002 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.051221107975965 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle