Protein Overview: vnd-PA

General Information:
Name(s) found:	vnd-PA / FBpp0070105 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7290055\|gb\|AAF45521.1\| ventral nervous system defective, isoform A [Drosophila melanogaster] [NCBI NR] gi\|47117833\|sp\|P22808.3\|VND_DROME RecName: Full=Homeobox protein vnd; AltName: Full=Protein ventral nervous system defective; AltName: Full=Homeobox protein NK-2 [NCBI NR] gi\|24638894\|ref\|NP_476786.2\| ventral nervous system defective, isoform A [Drosophila melanogaster] [NCBI NR] Homeobox protein vnd OS=Drosophila melanogaster GN=vnd PE=1 SV=3 [Swiss-Prot] (P22808) Homeobox protein vnd (Ventral nervous system defective protein) (Homeobox protein NK-2) [Swiss-Prot] The gene ventral nervous system defective is referred to in FlyBase by the symbol Dmel\vnd (CG6172, FBgn0003986). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:476732..491855. It has the cytological map location 1B10. There is experimental evidence that it has the molecular function</span>: transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; neuroblast fate determination; glial cell development; regulation of gene-specific transcription from RNA polymerase II promoter; brain development; neuroblast development. 80 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system; primordium; embryonic nervous system; embryonic neuron; nervous system; ventral nerve cord primordium; embryonic glial cell; multi-cell-component structure; portion of tissue; adult brain; neuroblast NB3-2; commissure; antennal segment; embryonic foregut; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG6172-PA translation from_gene[CG6172 vnd FBgn0003986] seq_release:3 mol_weight=76423 cds_boundaries:(X:348,832..354,745[+]) aa_length:723 transcript_info:[CG6172-RA seq_release:3] gene_info:[gene symbol:vnd FBgn0003986 gene_boundaries:(X:348,479..35 [hmr_yeast5_DM3-1_pombe.fasta] (AE003418) vnd gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG6172-PA [Drosophila melanogaster]gi\|24638894\|ref\|NP_476786.2\| CG6172-PA [Drosophila melanogaster]gi\|47117833\|sp\|P22808\|HMN2_DROME Homeobox protein vnd (Ventral nervous system defective protein) (Homeobox protein NK-2) [nrdb_11152004_Chlamydomonas] type=protein; loc=X:join(485428..485984,487681..488339,490389..491344); ID=FBpp0070105; name=vnd-PA; parent=FBgn0003986,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521; MD [fly-100309-contam.fasta] CG6172-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] Homeobox protein vnd (Protein ventral nervous system defective) (Homeobox protein NK-2) [nr-271106-contam.fasta] ventral nervous system defective CG6172-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=X:join(485428..485984,487681..488339,490389..491344); ID=FBpp0070105; name=vnd-PA; parent=FBgn0003986,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=X:join(485428..485984,487681..488339,490389..491344); ID=FBpp0070105; name=vnd-PA; parent=FBgn0003986,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=X:join(485428..485984,487681..488339,490389..491344); ID=FBpp0070105; name=vnd-PA; parent=FBgn0261930,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521,FlyMine:FBpp0070105,modMine:FBpp0070105; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=X:join(591395..591951,593648..594306,596356..597311); ID=FBpp0070105; name=vnd-PA; parent=FBgn0261930,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521,FlyMine:FBpp0070105,modMine:FBpp0070105; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=X:join(591395..591951,593648..594306,596356..597311); ID=FBpp0070105; name=vnd-PA; parent=FBgn0261930,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521,FlyMine:FBpp0070105,modMine:FBpp0070105; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0070105 type=protein; loc=X:join(591395..591951,593648..594306,596356..597311); ID=FBpp0070105; name=vnd-PA; parent=FBgn0261930,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521,FlyMine:FBpp0070105,modMine:FBpp0070105; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=X:join(591395..591951,593648..594306,596356..597311); ID=FBpp0070105; name=vnd-PA; parent=FBgn0261930,FBtr0070110; dbxref=FlyBase:FBpp0070105,FlyBase_Annotation_IDs:CG6172-PA,GB_protein:AAF45521.1,REFSEQ:NP_476786,GB_protein:AAF45521,UniProt/Swiss-Prot:P22808,FlyMine:FBpp0070105,modMine:FBpp0070105; MD5=6ead833c5f7860fb9131af75c564a767; length=723; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	723 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS][NAS]
Biological Process:	neuroblast fate determination [IMP][TAS] regulation of transcription, DNA-dependent [IEA][NAS] pattern specification process [NAS] brain development [IMP][TAS] ectoderm development [TAS] regulation of transcription [IEA] glial cell development [IMP] dorsal/ventral pattern formation [TAS] ventral cord development [NAS][TAS] central nervous system development [NAS] positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA] neuroblast development [IMP] regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
Molecular Function:	transcription factor activity [ISS] transcription regulator activity [NAS] sequence-specific DNA binding [IEA] transcription factor binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSASLERT PSKRDRDRER DNSSGLGSAG SLPASPQSAI TVSPSSPATP KRPLRTSTPS  60
   61 LERKREREDR EDREDRKERQ ERHERDRDHE RFAAVFSTAS TTVPTNTSSS SGLAPEQLRI 120
  121 PTGAAAFSGF PGLHSMSSLM LPSSAAVAAA AAAPFLPWSP ILLPPWNHAL LPAAFYPAAL 180
  181 RNALPGLFDA KVPSSQRSGF HISDILNLEG SELKNAAAAA AAAAHHGSDL SHHSASESTS 240
  241 GHRGQGSHTS PSALSPTPAG VSADEHHNGS GTGGGAGEAD HHSTTEHHAP PSHPQQQHPH 300
  301 HQQHHHPHLL LPQQHHQQAV APLPLAHHQS GEAQSHAHAN AAAAHLLASH NAAAAAAVAA 360
  361 GQYLPNLPKN FPGSFGDEMS SYHHMAQTML QHSGRSAWIK ENELYGTQQP ASPDSTSPVT 420
  421 SEVSYTYIGS NCQTSPALSG DYKSYSRSAD SDALSVGDAL HTLHGSSGNG SAGGAPTAHA 480
  481 LHNNNNNTTN NNNHSLKAEG INGAGSGHDD SLNEDGIEED IDDVDDADGS GGGDANGSDG 540
  541 LPNKKRKRRV LFTKAQTYEL ERRFRQQRYL SAPEREHLAS LIRLTPTQVK IWFQNHRYKT 600
  601 KRAQNEKGYE GHPGLLHGHA THPHHPSALP SPRRVAVPVL VRNGKPCLGD SSKLGADCVS 660
  661 VSSATATAMQ NAAAHHLVAL NGAAAYQHAA AAAAGLHAHA HAHAHAHGHG HPHAHAQRAA 720
  721 WWP

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..99]	deduced	N/A	No confident structure predictions are available.
2	View Details	[100..244]	MSA	3.206988	View MSA. No confident structure predictions are available.
3	View Details	[245..410]	PSI-BLAST	5.0	Sec24
4	View Details	[411..543]	deduced	N/A	No confident structure predictions are available.
5	View Details	[544..619]	PSI-BLAST	11.221849	VND/NK-2 protein
6	View Details	[620..723]	deduced	N/A	No confident structure predictions are available.

Protein Overview: vnd-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: