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Protein Overview: vnd-PA

General Information:
Name(s) found: vnd-PA / FBpp0070105 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene ventral nervous system defective is referred to in FlyBase by the symbol Dmel\vnd (CG6172, FBgn0003986). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:476732..491855. It has the cytological map location 1B10. There is experimental evidence that it has the molecular function</span>: transcription factor binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; neuroblast fate determination; glial cell development; regulation of gene-specific transcription from RNA polymerase II promoter; brain development; neuroblast development. 80 alleles are reported. The phenotypes of these alleles are annotated with 33 unique terms, many of which group under: organ system; primordium; embryonic nervous system; embryonic neuron; nervous system; ventral nerve cord primordium; embryonic glial cell; multi-cell-component structure; portion of tissue; adult brain; neuroblast NB3-2; commissure; antennal segment; embryonic foregut; late extended germ band embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 723 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: neuroblast fate determination [IMP][TAS]
    regulation of transcription, DNA-dependent [IEA][NAS]
    pattern specification process [NAS]
    brain development [IMP][TAS]
    ectoderm development [TAS]
    regulation of transcription [IEA]
    glial cell development [IMP]
    dorsal/ventral pattern formation [TAS]
    ventral cord development [NAS][TAS]
    central nervous system development [NAS]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    neuroblast development [IMP]
    regulation of gene-specific transcription from RNA polymerase II promoter [IMP]
    Molecular Function: transcription factor activity [ISS]
    transcription regulator activity [NAS]
    sequence-specific DNA binding [IEA]
    transcription factor binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTTSASLERT PSKRDRDRER DNSSGLGSAG SLPASPQSAI TVSPSSPATP KRPLRTSTPS  60
   61 LERKREREDR EDREDRKERQ ERHERDRDHE RFAAVFSTAS TTVPTNTSSS SGLAPEQLRI 120
  121 PTGAAAFSGF PGLHSMSSLM LPSSAAVAAA AAAPFLPWSP ILLPPWNHAL LPAAFYPAAL 180
  181 RNALPGLFDA KVPSSQRSGF HISDILNLEG SELKNAAAAA AAAAHHGSDL SHHSASESTS 240
  241 GHRGQGSHTS PSALSPTPAG VSADEHHNGS GTGGGAGEAD HHSTTEHHAP PSHPQQQHPH 300
  301 HQQHHHPHLL LPQQHHQQAV APLPLAHHQS GEAQSHAHAN AAAAHLLASH NAAAAAAVAA 360
  361 GQYLPNLPKN FPGSFGDEMS SYHHMAQTML QHSGRSAWIK ENELYGTQQP ASPDSTSPVT 420
  421 SEVSYTYIGS NCQTSPALSG DYKSYSRSAD SDALSVGDAL HTLHGSSGNG SAGGAPTAHA 480
  481 LHNNNNNTTN NNNHSLKAEG INGAGSGHDD SLNEDGIEED IDDVDDADGS GGGDANGSDG 540
  541 LPNKKRKRRV LFTKAQTYEL ERRFRQQRYL SAPEREHLAS LIRLTPTQVK IWFQNHRYKT 600
  601 KRAQNEKGYE GHPGLLHGHA THPHHPSALP SPRRVAVPVL VRNGKPCLGD SSKLGADCVS 660
  661 VSSATATAMQ NAAAHHLVAL NGAAAYQHAA AAAAGLHAHA HAHAHAHGHG HPHAHAQRAA 720
  721 WWP

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] deduced N/A No confident structure predictions are available.
    2 View Details [100..244] MSA 3.206988 View MSA. No confident structure predictions are available.
    3 View Details [245..410] PSI-BLAST 5.0 Sec24
    4 View Details [411..543] deduced N/A No confident structure predictions are available.
    5 View Details [544..619] PSI-BLAST 11.221849 VND/NK-2 protein
    6 View Details [620..723] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.33505905753956 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4 No functions predicted.
    5
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  3.5139760613123 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • transcription activator activity
    		•  3.10621734076555 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • protein binding
    		•  1.88087411289001 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • chromatin binding
    		•  1.68956710349366 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.33505905753956 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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