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Protein Overview: Ptx1-PA

General Information:
Name(s) found: Ptx1-PA / FBpp0088412 [FlyBase]
Description(s) found:
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  • gi|38258871|sp|O18400.2|PITX1_DROME RecName: Full=Pituitary homeobox 1 homolog; Short=D-PTX1 [NCBI NR]
  • gi|33589384|gb|AAQ22459.1| RE41906p [Drosophila melanogaster] [NCBI NR]
  • gi|28571942|ref|NP_733410.2| Ptx1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|28381509|gb|AAF57099.3| Ptx1, isoform A [Drosophila melanogaster] [NCBI NR]
  • (O18400) Pituitary homeobox 1 homolog (D-PTX1) [Swiss-Prot]
  • Pituitary homeobox homolog Ptx1 OS=Drosophila melanogaster GN=Ptx1 PE=2 SV=2 [Swiss-Prot]
  • Pituitary homeobox 1 homolog OS=Drosophila melanogaster GN=Ptx1 PE=2 SV=2 [Swiss-Prot]
  • The gene Ptx1 is referred to in FlyBase by the symbol Dmel\Ptx1 (CG1447, FBgn0020912). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26738610..26756404. It has the cytological map location 100A7-100B1. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: dendrite morphogenesis. 3 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • >CG1447-PA translation from_gene[CG1447 Ptx1 FBgn0020912] seq_release:3 mol_weight=53217 cds_boundaries:(3R:26,731,278..26,744,822[+]) aa_length:509 transcript_info:[CG1447-RA seq_release:3] gene_info:[gene symbol:Ptx1 FBgn0020912 gene_boundaries:(3R:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (AE003776) Ptx1 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG1447-PA, isoform A [Drosophila melanogaster]gi|33589384|gb|AAQ22459.1| RE41906p [Drosophila melanogaster]gi|28571942|ref|NP_733410.2| CG1447-PA [Drosophila melanogaster]gi|38258871|sp|O18400|PIX1_DROME Pituitary homeobox 1 homolog (D-PTX1) [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(26741912..26742443,26749140..26749280,26750035..26750288,26754857..26755459); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,REFSEQ:NP_733410,GB_protein:A [fly-100309-contam.fasta]
  • Ptx1 CG1447-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Pituitary homeobox 1 homolog (D-PTX1) [nr-271106-contam.fasta]
  • RE41906p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG1447-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(26741912..26742443,26749140..26749280,26750035..26750288,26754857..26755459); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,REFSEQ:NP_733410,GB_protein:AAF57099; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(26741912..26742443,26749140..26749280,26750035..26750288,26754857..26755459); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • type=protein; loc=3R:join(26741912..26742443,26749140..26749280,26750035..26750288,26754857..26755459); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410,FlyMine:FBpp0088412,modMine:FBpp0088412; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:join(30916190..30916721,30923418..30923558,30924313..30924566,30929135..30929737); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410,FlyMine:FBpp0088412,modMine:FBpp0088412; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(30916190..30916721,30923418..30923558,30924313..30924566,30929135..30929737); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410,FlyMine:FBpp0088412,modMine:FBpp0088412; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0088412 type=protein; loc=3R:join(30916190..30916721,30923418..30923558,30924313..30924566,30929135..30929737); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410,FlyMine:FBpp0088412,modMine:FBpp0088412; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(30916190..30916721,30923418..30923558,30924313..30924566,30929135..30929737); ID=FBpp0088412; name=Ptx1-PA; parent=FBgn0020912,FBtr0089389; dbxref=FlyBase_Annotation_IDs:CG1447-PA,FlyBase:FBpp0088412,GB_protein:AAF57099,REFSEQ:NP_733410,UniProt/Swiss-Prot:O18400,FlyMine:FBpp0088412,modMine:FBpp0088412; MD5=bcaa39a85e207ac7dfe942dc30cc734a; length=509; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 509 amino acids

    Gene Ontology:
    Cellular Component: transcription factor complex [ISS]
    Biological Process: regulation of transcription, DNA-dependent [IEA]
    regulation of transcription [IEA][ISS]
    dendrite morphogenesis [IMP]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRSSAVGGC GGGGGLGVGV VTSSATALGP GGLTNGGGGV VSGALNGLEA MSAESTGLCL  60
   61 QDLVSAGTAN GAGSAGSAES ATTTSTALSS GSTGSSTVNG GGSSTSGTEH LHSHHSLHDS 120
  121 SSSVSISPAI SSLMPISSLS HLHHSAGQDL VGGYSQHPHH TVVPPHTPKH EPLEKLRIWA 180
  181 ETGDFRDSHS SMTAVANSLD STHLNNFQTS STSSISNRSR DRKDGNRSVN ETTIKTENIS 240
  241 SSGHDEPMTT SGEEPKNDKK NKRQRRQRTH FTSQQLQELE HTFSRNRYPD MSTREEIAMW 300
  301 TNLTEARVRV WFKNRRAKWR KRERNAMNAA VAAADFKSGF GTQFMQPFAD DSLYSSYPYN 360
  361 NWTKVPSPLG TKPFPWPVNP LGSMVAGNHH QNSVNCFNTG ASGVAVSMNN ASMLPGSMGS 420
  421 SLSNTSNVGA VGAPCPYTTP ANPYMYRSAA EPCMSSSMSS SIATLRLKAK QHASAGFGSP 480
  481 YSAPSPVSRS NSAGLSACQY TGVGVTDVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..193] MSA 5.313993 View MSA. No confident structure predictions are available.
    2 View Details [194..258] deduced N/A No confident structure predictions are available.
    3 View Details [259..327] PSI-BLAST 15.045757 Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
    4 View Details [328..509] FFAS03 1.37 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.663171909351326 bayes_pls_golite062009
  • transcription coactivator activity
    		•  0.2679415219517 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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