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View Structure Prediction Details

Protein: Ptx1-PA
Organism: Drosophila melanogaster
Length: 509 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ptx1-PA.

Description E-value Query
Range
Subject
Range
Ptx1-PC - The gene Ptx1 is referred to in FlyBase by the symbol Dmel\Ptx1 (CG1447, FBgn0020912). It is a prote...
134.0 [0..1] [509..1]

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Predicted Domain #1
Region A:
Residues: [1-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRSSAVGGC GGGGGLGVGV VTSSATALGP GGLTNGGGGV VSGALNGLEA MSAESTGLCL  60
   61 QDLVSAGTAN GAGSAGSAES ATTTSTALSS GSTGSSTVNG GGSSTSGTEH LHSHHSLHDS 120
  121 SSSVSISPAI SSLMPISSLS HLHHSAGQDL VGGYSQHPHH TVVPPHTPKH EPLEKLRIWA 180
  181 ETGDFRDSHS SMT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [194-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVANSLDSTH LNNFQTSSTS SISNRSRDRK DGNRSVNETT IKTENISSSG HDEPMTTSGE  60
   61 EPKND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKNKRQRRQR THFTSQQLQE LEHTFSRNRY PDMSTREEIA MWTNLTEARV RVWFKNRRAK  60
   61 WRKRERNAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.045757
Match: 1yz8P
Description: Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.663171909351326 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [328-509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAAVAAADFK SGFGTQFMQP FADDSLYSSY PYNNWTKVPS PLGTKPFPWP VNPLGSMVAG  60
   61 NHHQNSVNCF NTGASGVAVS MNNASMLPGS MGSSLSNTSN VGAVGAPCPY TTPANPYMYR 120
  121 SAAEPCMSSS MSSSIATLRL KAKQHASAGF GSPYSAPSPV SRSNSAGLSA CQYTGVGVTD 180
  181 VV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.37
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle