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View Structure Prediction Details

Protein: Ptx1-PA
Organism: Drosophila melanogaster
Length: 509 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Ptx1-PA.

Description E-value Query
Range
Subject
Range
Ptx1-PC - The gene Ptx1 is referred to in FlyBase by the symbol Dmel\Ptx1 (CG1447, FBgn0020912). It is a prote...
134.0 [0..1] [509..1]

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Predicted Domain #1
Region A:
Residues: [1-193]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRSSAVGGC GGGGGLGVGV VTSSATALGP GGLTNGGGGV VSGALNGLEA MSAESTGLCL  60
   61 QDLVSAGTAN GAGSAGSAES ATTTSTALSS GSTGSSTVNG GGSSTSGTEH LHSHHSLHDS 120
  121 SSSVSISPAI SSLMPISSLS HLHHSAGQDL VGGYSQHPHH TVVPPHTPKH EPLEKLRIWA 180
  181 ETGDFRDSHS SMT

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [194-258]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AVANSLDSTH LNNFQTSSTS SISNRSRDRK DGNRSVNETT IKTENISSSG HDEPMTTSGE  60
   61 EPKND

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [259-327]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KKNKRQRRQR THFTSQQLQE LEHTFSRNRY PDMSTREEIA MWTNLTEARV RVWFKNRRAK  60
   61 WRKRERNAM

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 15.045757
Match: 1yz8P
Description: Solution structure of the k50 class homeodomain pitx2 bound to dna and implications for mutations that cause rieger syndrome
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 5.13863038737912 bayes_pls_golite062009
DNA binding 4.66369707598026 bayes_pls_golite062009
nucleic acid binding 4.20953772435302 bayes_pls_golite062009
transcription factor activity 4.06706589695599 bayes_pls_golite062009
binding 3.02779747447702 bayes_pls_golite062009
sequence-specific DNA binding 2.41271657675151 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.26183812259792 bayes_pls_golite062009
transcription repressor activity 1.91962622287073 bayes_pls_golite062009
transcription activator activity 1.77700860354597 bayes_pls_golite062009
transcription factor binding 1.40653841901929 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 1.14886080629275 bayes_pls_golite062009
chromatin binding 0.876241359231159 bayes_pls_golite062009
transcription cofactor activity 0.84983974758882 bayes_pls_golite062009
protein binding 0.830419844171551 bayes_pls_golite062009
general RNA polymerase II transcription factor activity 0.663171909351326 bayes_pls_golite062009
transcription coactivator activity 0.2679415219517 bayes_pls_golite062009
transcription corepressor activity 0.25931464844298 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [328-509]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NAAVAAADFK SGFGTQFMQP FADDSLYSSY PYNNWTKVPS PLGTKPFPWP VNPLGSMVAG  60
   61 NHHQNSVNCF NTGASGVAVS MNNASMLPGS MGSSLSNTSN VGAVGAPCPY TTPANPYMYR 120
  121 SAAEPCMSSS MSSSIATLRL KAKQHASAGF GSPYSAPSPV SRSNSAGLSA CQYTGVGVTD 180
  181 VV

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 1.37
Match: 1pk8A
Description: Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle