Protein Overview: Sry-delta-PA

General Information:
Name(s) found:	Sry-delta-PA / FBpp0084924 [FlyBase]
Description(s) found: Found 22 descriptions. SHOW ALL	The gene Serendipity Ă?Ă?Â´ is referred to in FlyBase by the symbol Dmel\Sry-Ă?Ă?Â´ (CG17958, FBgn0003512). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25869068..25870613. It has the cytological map location 99D3. There is experimental evidence that it has the molecular function</span>: DNA binding. There is experimental evidence that it is involved in the biological process</span>: oogenesis; determination of anterior/posterior axis, embryo. 19 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; cephalopharyngeal skeleton; testis; spermatozoon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
Organism:	Drosophila melanogaster
Length:	433 amino acids
Gene Ontology:
Cellular Component:	nucleus [IDA][NAS] polytene chromosome interband [IDA]
Biological Process:	anterior/posterior axis specification, embryo [IGI][IMP] oogenesis [IGI][NAS] regulation of transcription, DNA-dependent [NAS]
Molecular Function:	DNA binding [IDA] zinc ion binding [IEA] transcription activator activity [NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDTCFFCGAV DLSDTGSSSS MRYETLSAKV PSSQKTVSLV LTHLANCIQT QLDLKPGARL  60
   61 CPRCFQELSD YDTIMVNLMT TQKRLTTQLK GALKSEFEVP ESGEDILVEE VEIPQSDVET 120
  121 DADAEADALF VELVKDQEES DTEIKREFVD EEEEEDDDDD DEFICEDVDV GDSEALYGKS 180
  181 SDGEDRPTKK RVKQECTTCG KVYNSWYQLQ KHISEEHSKQ PNHICPICGV IRRDEEYLEL 240
  241 HMNLHEGKTE KQCRYCPKSF SRPVNTLRHM RMHWDKKKYQ CEKCGLRFSQ DNLLYNHRLR 300
  301 HEAEENPIIC SICNVSFKSR KTFNHHTLIH KENRPRHYCS VCPKSFTERY TLKMHMKTHE 360
  361 GDVVYGVREE APADEQQVVE ELHVDVDESE AAVTVIMSDN DENSGFCLIC NTNFENKKEL 420
  421 EHHLQFDHDV VLK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..86]	FFAS03	0.992	Crystal structure of the zinc finger associated domain of the Drosophila transcription factor Grauzone
2	View Details	[87..175]	deduced	N/A	No confident structure predictions are available.
3	View Details	[176..353]	PSI-BLAST	59.522879	No description for 2i13A was found.
4	View Details	[354..433]	FFAS03	1.06	Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa

Functions predicted (by domain):

#

Gene Ontology predictions

1

Term	Confidence	Notes
transcription regulator activity	3.84932768708444	bayes_pls_golite062009
DNA binding	3.45124926204188	bayes_pls_golite062009
nucleic acid binding	3.34875987514951	bayes_pls_golite062009
binding	2.8684204787273	bayes_pls_golite062009
transcription factor activity	2.74592237402384	bayes_pls_golite062009
transcription activator activity	1.45965791386122	bayes_pls_golite062009
sequence-specific DNA binding	1.44741411126911	bayes_pls_golite062009
RNA polymerase II transcription factor activity	1.32499836066598	bayes_pls_golite062009
protein binding	1.30321965120678	bayes_pls_golite062009
transcription factor binding	1.22761682002	bayes_pls_golite062009
ligand-dependent nuclear receptor activity	1.1269808729848	bayes_pls_golite062009
structural constituent of ribosome	1.0478696280786	bayes_pls_golite062009
structural molecule activity	0.958501322313092	bayes_pls_golite062009
transcription cofactor activity	0.449959641856445	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.446369866668139	bayes_pls_golite062009
transcription repressor activity	0.199267983374872	bayes_pls_golite062009
catalytic activity	0.133319360419662	bayes_pls_golite062009

2

No functions predicted.

3

No functions predicted.

4

Term	Confidence	Notes
transcription regulator activity	4.47951889934838	bayes_pls_golite062009
nucleic acid binding	4.35187767955595	bayes_pls_golite062009
DNA binding	4.31051339571017	bayes_pls_golite062009
transcription factor activity	3.28758716579796	bayes_pls_golite062009
binding	2.99742524370422	bayes_pls_golite062009
RNA polymerase II transcription factor activity	2.05542379535543	bayes_pls_golite062009
transcription activator activity	1.97757778483124	bayes_pls_golite062009
transcription repressor activity	1.44763794968807	bayes_pls_golite062009
sequence-specific DNA binding	1.26862497534835	bayes_pls_golite062009
chromatin binding	1.26688155139311	bayes_pls_golite062009
transcription factor binding	1.23738346570539	bayes_pls_golite062009
protein binding	0.952480850696098	bayes_pls_golite062009
specific RNA polymerase II transcription factor activity	0.776754909146767	bayes_pls_golite062009
transcription cofactor activity	0.627794176881836	bayes_pls_golite062009
catalytic activity	0.263007611601737	bayes_pls_golite062009

Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.95

Source: Reynolds et al. (2008)

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle