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Protein Overview: Dr-PA

General Information:
Name(s) found: Dr-PA / FBpp0084807 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Drop is referred to in FlyBase by the symbol Dmel\Dr (CG1897, FBgn0000492). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25382109..25391007. It has the cytological map location 99B3. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity; DNA binding. There is experimental evidence that it is involved in the biological process</span>: glial cell development; dorsal/ventral pattern formation, imaginal disc; wing and notum subfield formation; imaginal disc-derived wing morphogenesis; regulation of cell fate specification; wing disc pattern formation. 54 alleles are reported. The phenotypes of these alleles are annotated with 161 unique terms, many of which group under: hypodermal muscle of larval abdomen; organ system; abdominal transverse muscle; abdominal oblique muscle; larval abdominal segment 5; hypodermal muscle of metathorax; thoracic segment; hypodermal muscle of mesothorax; abdominal ventral acute muscle 2; abdominal segment 7. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: regulation of cell fate specification [IMP]
    wing disc pattern formation [IMP]
    dorsal/ventral pattern formation, imaginal disc [IMP]
    imaginal disc-derived wing morphogenesis [IMP]
    nervous system development [NAS]
    neuroblast fate determination [TAS]
    regulation of transcription, DNA-dependent [IEA]
    pattern specification process [NAS]
    ectoderm development [TAS]
    brain development [TAS]
    regulation of transcription [IEA][NAS]
    glial cell development [IMP]
    dorsal/ventral pattern formation [TAS]
    muscle organ development [NAS][TAS]
    ventral cord development [NAS][TAS]
    central nervous system development [NAS]
    wing and notum subfield formation [IMP]
    Molecular Function: DNA binding [ISS]
    transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLKLSPASMT VTGLRQTMTS PTVPPSSNTP AGNLIITSSS SNSGSNSGSN MSSGNMTSSN  60
   61 LTNLSPSHPA GLNALASPTS PSALLLAHQQ HLLQQHQQHQ QQQQQQQQAA ALQLAAVHPP 120
  121 AHHLHKTTSR LSNFSVASLL ADTRPRTPPN QAADGPQNLT SSAATSPISQ ASSTPPPPPA 180
  181 SAAAQVPANT FHPAAVAHHA HLLQAAHAAA AAHAQHQAMA AQLRQQQQQA DARANSPPAS 240
  241 TSSTPSSTPL GSALGSQGNV ASTPAKNERH SPLGSHTDSE LEYDEEMLQD HEADHDEEED 300
  301 SIVDIEDMNA DDSPRSTPDG LDGSGKSLES PHGPPPGSHM QSTILSPAAL ASGHVPIRPT 360
  361 PFSALAAAAV AWTGMGGGVP WPGTRQMPPF GPPGMFPGAG FGGDANEPPR IKCNLRKHKP 420
  421 NRKPRTPFTT QQLLSLEKKF REKQYLSIAE RAEFSSSLRL TETQVKIWFQ NRRAKAKRLQ 480
  481 EAEIEKIKMA ALGRGAPGAQ WAMAGYFHPS LMHLG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..180] PSI-BLAST 3.154902 Sec24
    2 View Details [181..414] deduced N/A No confident structure predictions are available.
    3 View Details [415..515] PSI-BLAST 18.0 Msx-1 homeodomain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.28

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle