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Protein Overview: spn-D-PA

General Information:
Name(s) found: spn-D-PA / FBpp0084486 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene spindle D is referred to in FlyBase by the symbol Dmel\spn-D (CG31069, FBgn0003482). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22991440..22992844. It has the cytological map location 97E6. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: DNA-dependent ATPase activity; DNA binding; ATP binding. There is experimental evidence that it is involved in the biological process</span>: germarium-derived oocyte fate determination; microtubule organizing center organization; polarity specification of dorsal/ventral axis; intracellular mRNA localization; oogenesis; polarity specification of anterior/posterior axis; dorsal appendage formation; karyosome formation; oocyte localization during germarium-derived egg chamber formation. 10 alleles are reported. The phenotypes of these alleles are annotated with: germline cyst; oocyte; presumptive oocyte; karyosome; dorsal appendage; nurse cell; synaptonemal complex. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 270 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: polarity specification of anterior/posterior axis [IMP]
    intracellular mRNA localization [IMP][TAS]
    reciprocal meiotic recombination [TAS]
    oogenesis [IGI][TAS]
    germarium-derived oocyte fate determination [IGI]
    karyosome formation [IMP]
    polarity specification of dorsal/ventral axis [IMP]
    dorsal appendage formation [IMP]
    oocyte differentiation [NAS]
    microtubule organizing center organization [IMP]
    DNA metabolic process [IEA]
    oocyte localization during germarium-derived egg chamber formation [IMP]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    DNA-dependent ATPase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNHRFVRVWE PSQPEAIERR PSVSHENFRI FDKSCWDISQ SASNKILTGK KALDTHFGGG  60
   61 ISLGHLVELI GNSGTGKTQM CLQLCLNVQI PKAAGGLEGS ALFIDTRQDF HPDRLMGLAL 120
  121 KLERQYAHRV PEFKAHKMLQ KIHYVRCPKL DQLMATVLSC HRHLVDHPDI KLIVIDSLAF 180
  181 TLRMLEDGAH RYEMLLELHE SMRRLQRQHE LTWVFTNVLT HRYVKQKFQV EPALGDLHSH 240
  241 LINERIWFSG SSELHLGKSW RTSRLIKESE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..270] PSI-BLAST 54.39794 Crystal structure of the human Dmc1 protein

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleoside-triphosphatase activity
    		•  1.69240737024755 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  1.65296291878002 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  1.64318297340116 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  1.64169398852165 bayes_pls_golite062009
  • catalytic activity
    		•  1.37148167194523 bayes_pls_golite062009
  • ATPase activity
    		•  1.20060977637766 bayes_pls_golite062009
  • binding
    		•  1.15787013909653 bayes_pls_golite062009
  • transporter activity
    		•  1.14815595550467 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.08141765801535 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.01232806016411 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.92246823619313 bayes_pls_golite062009
  • P-P-bond-hydrolysis-driven transmembrane transporter activity
    		•  0.89546790004613 bayes_pls_golite062009
  • primary active transmembrane transporter activity
    		•  0.89065853471483 bayes_pls_golite062009
  • hydrolase activity
    		•  0.875592967682638 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
    		•  0.8668136831732 bayes_pls_golite062009
  • ATPase activity, coupled to movement of substances
    		•  0.86536264587818 bayes_pls_golite062009
  • ATPase activity, coupled to transmembrane movement of substances
    		•  0.86511385357843 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.3056113353665 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.30512981340046 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.30259037403175 bayes_pls_golite062009
  • nucleotide binding
    		•  0.28998663538132 bayes_pls_golite062009
  • motor activity
    		•  0.19423019377616 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.0959138026858399 bayes_pls_golite062009
  • helicase activity
    		•  0.00674361801283974 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle