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Protein Overview: ro-PB, ro-PA

General Information:
Name(s) found: ro-PB / FBpp0084461 [FlyBase]
ro-PA / FBpp0084460 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene rough is referred to in FlyBase by the symbol Dmel\ro (CG6348, FBgn0003267). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22702493..22706893. It has the cytological map location 97D4-97D5. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of transcription, DNA-dependent. 70 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; retina; macrochaeta; primary pigment cell; cone cell; eye photoreceptor cell; lens; ommatidium; morphogenetic furrow. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene rough is referred to in FlyBase by the symbol Dmel\ro (CG6348, FBgn0003267). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:22702493..22706893. It has the cytological map location 97D4-97D5. Based on sequence similarity, it is predicted to have molecular function</span>: transcription factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: regulation of transcription, DNA-dependent. 70 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; eye; retina; macrochaeta; primary pigment cell; cone cell; eye photoreceptor cell; lens; ommatidium; morphogenetic furrow. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: negative regulation of R8 cell differentiation [NAS]
    R2/R5 cell differentiation [NAS]
    R8 cell fate specification [TAS]
    R8 cell fate commitment [NAS]
    regulation of transcription, DNA-dependent [IEA][ISS]
    regulation of transcription [IEA]
    compound eye development [NAS]
    Molecular Function: transcription factor activity [ISS]
    sequence-specific DNA binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRHKVEIGS PDGSPGIKRS DSLDPIANTT ILSVPQRPSS PRQFFERLYG HLETRSSENG  60
   61 EIDVGTHAHK PPPCDTPYHS DGGSVSSPDI SISDERTSLA AYPAYDFYGH AKDYPQHPSQ 120
  121 QHQQHHHHHH HPPQLVHQKL SYVSPPPAIA AGGAANPVLP HAFPAGFPSD PHFSAGFSAF 180
  181 LARRRRKEGR QRRQRTTFST EQTLRLEVEF HRNEYISRSR RFELAETLRL TETQIKIWFQ 240
  241 NRRAKDKRIE KAQIDQHYRN FVVANGFMSS IMGQAATTMP PGGVTGGVAV GVGLNYYAAA 300
  301 ATPAALPKDN TQDANFIDID DQFQRQQQQK QQQQQQQQRR RETTTPINIC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..145] FFAS03 1.05 Hepatitis C Virus NS5b RNA Polymerase in complex with a covalent inhibitor (5h)
    2 View Details [146..253] PSI-BLAST 25.0 Homeobox protein hox-b1
    3 View Details [254..350] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.51452285155271 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.26183812259792 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.14886080629275 bayes_pls_golite062009
  • chromatin binding
    		•  1.04132983826241 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.73

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle