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Protein Overview: gi|24650134, gi|...

General Information:
Name(s) found: gi|24650134 [NCBI NR]
gi|23172322 [NCBI NR]
Description(s) found:
Found 9 descriptions.
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  • gi|24650134|ref|NP_733119.1| LpR1, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|23172322|gb|AAF56499.2| LpR1, isoform A [Drosophila melanogaster] [NCBI NR]
    • Organism: Drosophila melanogaster
    Length: 883 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISS]
    Biological Process: cholesterol metabolic process [ISS]
    receptor-mediated endocytosis [IEP][IMP]
    lipoprotein transport [ISS]
    Molecular Function: lipoprotein binding [ISS]
    calcium ion binding [IEA]
    low-density lipoprotein receptor activity [ISS]
    receptor activity [IEP][IMP]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGRIWCLLFV SSLLHTQSQS FRVLAINEAT CSSDQFRCGN GNCIPNKWRC DQESDCADGS  60
   61 DEANELCRAR TCSPDEYACK SGEGQCVPLA WMCDQSKDCS DGSDEHNCNQ TCRADEFTCG 120
  121 NGRCIQKRWK CDHDDDCGDG SDEKECPVVP CDSVAEHTCT NGACIAKRWV CDGDPDCSDG 180
  181 SDERSCANVT KTTTPCLSHE YQCKDRITCL HHSWLCDGDR DCPDGDDEHT ANCKNVTCRA 240
  241 DQFQCGDRSC IPGHLTCNGD KDCADGSDER DCGLSLSLGI NQGGCNATSE FDCGGGQCVP 300
  301 LSKVCDKRKD CPDGEDEPAG KCGINECASK NGGCMHQCID LKVGHHCECH EGYKLSPDKR 360
  361 NCQDINECEV PGKCSQICVN EIGGFKCECE AGYMRDPKNH TRCKASEGHA SLLLARRHDI 420
  421 RKIALDHMEM TSIVNSTKAA TALDFVFRTG MIFWSDVTTQ SIYKAPIDEG NEKTVVLTKS 480
  481 SVTSDGLAVD WIYNHVYFTD THKCTIELTN FEGSMGKVLV KDSLDIPRSI ALDPIEGWMY 540
  541 WSDWGASPRI ERAGMDGSHR TTIISYDVKW PNGITLDLVK KRIYWVDGKL NVISSANYDG 600
  601 SQRSQVLYSG EYLRHPFSIT TFEDNVYWTD WDKQAVFKAN KFTGEDVEPV TAMHMLQHPM 660
  661 VVHVYHPYRQ PDGVNHCQSV NGHCSHLCLP APRINERSPR ISCACPTGLK LMVDGLMCVE 720
  721 DLTRPPRARK TKPRPKSPRR RLPTGVQVGH ADIRIEINDD LQLSTRLPLL PTTFVADQRP 780
  781 VKNHTQIEKT TTPSEQPDSG FIALVVIASL SGFAVLLSVL LLIGYRYCSK RRINSMNFEN 840
  841 PIYRKTTTTE DHFSLRKNLP ARIYDHTSVM DEEYSPVIGI SSY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..796] PSI-BLAST 131.0 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    2 View Details [797..883] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • very-low-density lipoprotein receptor activity
    		•  7.75680908341624 bayes_pls_golite062009
  • very-low-density lipoprotein binding
    		•  7.75680908341624 bayes_pls_golite062009
  • low-density lipoprotein binding
    		•  6.26591728596226 bayes_pls_golite062009
  • receptor activity
    		•  5.18957329214193 bayes_pls_golite062009
  • transmembrane receptor activity
    		•  5.12821337870369 bayes_pls_golite062009
  • molecular transducer activity
    		•  4.28859337937742 bayes_pls_golite062009
  • signal transducer activity
    		•  4.28859337937742 bayes_pls_golite062009
  • lipoprotein binding
    		•  4.14588039269064 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  4.1172010378646 bayes_pls_golite062009
  • low-density lipoprotein receptor activity
    		•  3.65371958920557 bayes_pls_golite062009
  • lipoprotein receptor binding
    		•  3.5371428063122 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  3.52219710022937 bayes_pls_golite062009
  • lipoprotein receptor activity
    		•  3.27342368855237 bayes_pls_golite062009
  • apolipoprotein binding
    		•  3.15697162337516 bayes_pls_golite062009
  • binding
    		•  3.10919144943954 bayes_pls_golite062009
  • glycosaminoglycan binding
    		•  2.86713236325679 bayes_pls_golite062009
  • heparin binding
    		•  2.49012176521764 bayes_pls_golite062009
  • polysaccharide binding
    		•  2.16901652361989 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.16844098063599 bayes_pls_golite062009
  • sterol transporter activity
    		•  2.16184949636569 bayes_pls_golite062009
  • apolipoprotein E binding
    		•  2.15688766106363 bayes_pls_golite062009
  • protein binding
    		•  2.11668700345827 bayes_pls_golite062009
  • receptor binding
    		•  2.00382722979859 bayes_pls_golite062009
  • lipid transporter activity
    		•  1.91872326766441 bayes_pls_golite062009
  • lipoprotein transporter activity
    		•  1.72944996169507 bayes_pls_golite062009
  • transcription factor binding
    		•  1.71838409809333 bayes_pls_golite062009
  • transcription cofactor activity
    		•  1.61057978332614 bayes_pls_golite062009
  • high-density lipoprotein binding
    		•  1.52515316728946 bayes_pls_golite062009
  • growth factor activity
    		•  1.52153421000803 bayes_pls_golite062009
  • transporter activity
    		•  1.44005597324471 bayes_pls_golite062009
  • collagen binding
    		•  1.3611207932336 bayes_pls_golite062009
  • protein transporter activity
    		•  1.27232657510644 bayes_pls_golite062009
  • pattern binding
    		•  1.26957983931218 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.08803800589535 bayes_pls_golite062009
  • protein kinase activity
    		•  1.00235965838736 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.741912411452008 bayes_pls_golite062009
  • carbohydrate binding
    		•  0.72748768329894 bayes_pls_golite062009
  • kinase activity
    		•  0.692244195382463 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.67022333774569 bayes_pls_golite062009
  • extracellular matrix structural constituent
    		•  0.66981956037474 bayes_pls_golite062009
  • cell adhesion molecule binding
    		•  0.44857826904729 bayes_pls_golite062009
  • extracellular matrix binding
    		•  0.3265100728106 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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