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Protein Overview: XNP-PB, XNP-PA

General Information:
Name(s) found: XNP-PB / FBpp0084213 [FlyBase]
XNP-PA / FBpp0084212 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene XNP is referred to in FlyBase by the symbol Dmel\XNP (CG4548, FBgn0039338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21303590..21308549. It has the cytological map location 96E1-96E2. It is reported to have molecular function</span>: general RNA polymerase II transcription factor activity; DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of JNK cascade; induction of apoptosis; axon guidance; glial cell migration; nervous system development; chromosome organization. 13 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; embryonic glial cell; posterior commissure; adult thorax; Kenyon cell; interface glial cell; longitudinal connective; microchaeta; scutellum; anterior commissure. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene XNP is referred to in FlyBase by the symbol Dmel\XNP (CG4548, FBgn0039338). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21303590..21308549. It has the cytological map location 96E1-96E2. It is reported to have molecular function</span>: general RNA polymerase II transcription factor activity; DNA helicase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of JNK cascade; induction of apoptosis; axon guidance; glial cell migration; nervous system development; chromosome organization. 13 alleles are reported. The phenotypes of these alleles are annotated with: mushroom body; embryonic glial cell; posterior commissure; adult thorax; Kenyon cell; interface glial cell; longitudinal connective; microchaeta; scutellum; anterior commissure. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1311 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    polytene chromosome [IDA]
    chromosome, centromeric region [IDA]
    Biological Process: transcription [NAS]
    induction of apoptosis [IMP]
    chromosome organization [IMP]
    nervous system development [IMP]
    axon guidance [IMP]
    glial cell migration [IMP]
    regulation of JNK cascade [IGI]
    Molecular Function: DNA binding [IEA]
    ATP binding [IEA]
    DNA helicase activity [NAS]
    general RNA polymerase II transcription factor activity [NAS]
    helicase activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKNPNARH TDAATPLTTD DSNSSSVSRR ESATESKSAS ESESSPPRSN TKQSRTHKNV  60
   61 KASGKATVSS SSDSDQAVAN SSANDEEKEP VCKIRIVPLE KLLASPKTKE RPSRGSQQKN 120
  121 VTINDSSDEE PLKGSKLVLP ARKSRNKNAS IIELSDSEEV DEEEESLLVA IPLPKEAQQT 180
  181 KPEKNSSKAS KESIEKRQKA QKEATTSSAR AIRSVNGTRR GSLSSERSSR ASSSRAESPP 240
  241 RPKRCVVRLK RVSLPKTKPA QKPKKMSSDS EEAATTSKKS RQRRSKSESE ADSDYEAPAA 300
  301 EEEEEEERKS SGDEEEAANS SDSEVMPQRK RRRKKSESDK GSSDFEPEEK QKKKGRKRIK 360
  361 KTSSGESDGD GDDDKQKNKR KHIRKIIKTK DLDLTTKEAA KEEDDRRKRI EDRQKLYNRI 420
  421 FVKSESVEIN ELVLDFDEES KKALLQVDKG LLKKLKPHQV AGVKFMWDAC FETLKESQEK 480
  481 PGSGCILAHC MGLGKTLQVV TLSHTLLVNT RRTGVDRVLI ISPLSTVNNW AREFTSWMKF 540
  541 ANRNDIEVYD ISRYKDKPTR IFKLNEWFNE GGVCILGYDM YRILANEKAK GLRKKQREQL 600
  601 MQALVDPGPD LVVCDEGHLL KNEKTSISKA VTRMRTKRRI VLTGTPLQNN LREYYCMIQF 660
  661 VKPNLLGTYK EYMNRFVNPI TNGQYTDSTE RDLRLMKHRS HILHKLLEGC IQRRDYSVLA 720
  721 PYLPPKHEYV VYTTLSELQQ KLYGYYMTTH REQSGGDVVG KGARLFQDFQ DLRRIWTHPM 780
  781 NLRVNSDNVI AKRLLSNDDS DMEGFICDET DEDEAASNSS DSCETFKSDA SMSGLAASSG 840
  841 KVKKRKTRNG NAGGGDSDSD LEMLGGLGGG SSVQKDDPSE WWKPFVEERE LNNVHHSPKL 900
  901 LILLRLLQQC EAIGDKLLVF SQSLQSLDVI EHFLSLVDSN TKNYEFEGDV GDFKGCWTSG 960
  961 KDYFRLDGSC SVEQREAMCK QFNNITNLRA RLFLISTRAG GLGINLVAAN RVVIFDVSWN1020
 1021 PSHDTQSIFR VYRFGQIKPC YIYRLIAMGT MEQKVYERQV AKQATAKRVI DEQQISRHYN1080
 1081 QTDLMELYSY ELKPSTEREM PILPKDRLFA EILTEHEKLI FKYHEHDSLL EQEEHENLTE1140
 1141 EERKSAWAEY EAEKTRTVQA SQYMSYDRNA FGNQVMGQFG NASGSVTSNK IFGFRSDILL1200
 1201 QLLNMKISKD HQELNQNQVI QLVPTYLQQL YNEMNNGDPT MYKDLLNLHS NIVHPSGMYM1260
 1261 NPLLYANQNP NAAGYNQGTG GVPPMAGGSV AHGPPAAPAP GFEPDKVYEI D

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..161] MSA 3.417997 View MSA. No confident structure predictions are available.
    2 View Details [162..395] deduced N/A No confident structure predictions are available.
    3 View Details [396..939] PSI-BLAST 88.0 Structure of the SWI2/SNF2 chromatin remodeling domain of eukaryotic Rad54
    4 View Details [940..1090] PSI-BLAST 29.69897 Sulfolobus solfataricus SWI2/SNF2 ATPase C-terminal domain
    5 View Details [1091..1311] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  3.16853848306485 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  2.36915495988847 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  2.29436982996465 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  2.27303683020046 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  2.27190707957159 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.09956015274464 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09345198747025 bayes_pls_golite062009
  • DNA binding
    		•  1.87765278833074 bayes_pls_golite062009
  • ATPase activity
    		•  1.76238574289941 bayes_pls_golite062009
  • ATPase activity, coupled
    		•  1.57826779898847 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  1.23094623498843 bayes_pls_golite062009
  • motor activity
    		•  1.14667913749579 bayes_pls_golite062009
  • catalytic activity
    		•  1.00104173493322 bayes_pls_golite062009
  • hydrolase activity
    		•  0.98565595572967 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.75415390146713 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.725611289205392 bayes_pls_golite062009
  • nucleotide binding
    		•  0.717697610309727 bayes_pls_golite062009
  • purine ribonucleotide binding
    		•  0.713814218071151 bayes_pls_golite062009
  • ribonucleotide binding
    		•  0.713752628021599 bayes_pls_golite062009
  • transcription factor activity
    		•  0.682439846757997 bayes_pls_golite062009
  • microtubule motor activity
    		•  0.60036517876321 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  0.500462538667228 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.41398614759796 bayes_pls_golite062009
  • protein binding
    		•  0.193768631623192 bayes_pls_golite062009
  • ATP binding
    		•  0.19169045543599 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.165732470448462 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162060759063149 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.144154288308693 bayes_pls_golite062009
  • centromeric DNA binding
    		•  0.120185906020979 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  0.114463153989353 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.089234257580272 bayes_pls_golite062009
  • helicase activity
    		•  0.0775311459068899 bayes_pls_golite062009
  • actin binding
    		•  0.00482938540552702 bayes_pls_golite062009
    4 No functions predicted.
    5 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle